| Neuroreport. 2003 Mar 3;14(3):399-403. |
| Long-lasting facilitation by dehydroevodiamine. HClof synaptic responses evoked in the CA1 region of rat hippocampal slices.[Pubmed: 12634491] |
METHODS AND RESULTS:
We tested the effects of dehydroevodiamine.Cl (Dehydroevodiamine Chloride, DHED) on field excitatory postsynaptic potentials (fEPSPs) evoked by the electrical stimulation of Schaffer collaterals-commissural fibres in the CA1 region of rat hippocampal slices. Bath applications of 10 microM DHED for 20 or 40 min induced long-lasting facilitation of fEPSPs, which outlasted the presence of DHED. A 10 min treatment with a higher concentration (100 microM) also induced long-lasting facilitation. The long-lasting facilitation was blocked either by 10 microM atropine, the muscarinic receptor antagonist, or by 50 microM D-2-amino-5-phosphonopentanoic acid (D-AP5), an NMDA receptor antagonist.
CONCLUSIONS:
These results show that DHED produces long-lasting facilitation of synaptic transmission, and that this facilitation depends upon the activation of both the muscarinic and NMDA receptors. |
| The Korean Journal of Physiology & Pharmacology, 2014, 18(1):55. |
| Dehydroevodiamine·HCl Improves Stress-Induced Memory Impairments and Depression Like Behavior in Rats[Pubmed: 24634597 ] |
Dehydroevodiamine·HCl (Dehydroevodiamine Chloride,DHED) has been reported to prevent memory impairment and neuronal cell loss in a rat model with cognitive disturbance. We investigated the effect of DHED on memory impairment and behavioral abnormality caused by stress.
METHODS AND RESULTS:
We demonstrated that DHED can improve stress-induced memory impairments and depression-like behaviors by using open-field test, Y-maze test and forced swimming test. DHED treatment significantly recovered the decreases in the levels of neural cell adhesion molecule (NCAM) proteins caused by stress and the decreases in cell viability.
CONCLUSIONS:
Our results suggested that DHED is a potential drug candidate for neuronal death, memory impairment and depression induced by stress. |
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