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  • 去氢双儿茶素A

    Dehydrodicatechin A

    去氢双儿茶素A
    产品编号 CFN95451
    CAS编号 36048-23-4
    分子式 = 分子量 C30H24O12 = 576.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The roots of Rubus crataegifolius
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    去氢双儿茶素A CFN95451 36048-23-4 1mg QQ客服:2159513211
    去氢双儿茶素A CFN95451 36048-23-4 5mg QQ客服:2159513211
    去氢双儿茶素A CFN95451 36048-23-4 10mg QQ客服:2159513211
    去氢双儿茶素A CFN95451 36048-23-4 20mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Emirates Journal of Food and Agriculture.2022, 34(6): 528-536.
  • Korean J Environ Agric.2018, 37(4):260-267
  • Front Microbiol.2022, 12:833233.
  • APMIS.2019, 127(10):688-695
  • Front Pharmacol.2020, 11:566490.
  • Nutrients.2018, 11(1):E17
  • Oncotarget.2017, 9(3):4161-4172
  • Int Immunopharmacol.2019, 71:361-371
  • Plant Pathology2022, 13527
  • Phytomedicine.2024, 126:155442.
  • Sci Rep. 2018, 462(8)
  • Chemistry of Natural Compounds2018, 54(3):572-576
  • University of Manitoba2023, 37433.
  • Biomed Pharmacother.2024, 173:116319.
  • J Hepatocell Carcinoma.2022, 9:327-341.
  • PLoS One.2018, 13(3):e0193386
  • Natural Product Communications2020, doi: 10.1177.
  • Korean Journal of Pharmacognosy.2020, 51(2):100-106
  • mBio.2020, 11(3):e00686-20.
  • Anal Sci.2019, 35(12):1317-1325
  • Plants (Basel).2023, 12(11):2107.
  • BioResources J.2020, 15(3).
  • Int J Biol Macromol.2019, 126:653-661
  • ...
  • 生物活性
    Description: The peroxidase-mediated (+)-catechin oxidation was differentially inhibited by dehydrodicatechin A, showing a competitive type inhibition and a k(I) of 6.4 microM. Dehydrobisphenol A has anticancer and antioxidant activity.
    In vitro:
    J Agric Food Chem. 2002 Feb 27;50(5):1218-1224.
    Comparative study of the products of the peroxidase-catalyzed and the polyphenoloxidase-catalyzed (+)-catechin oxidation. Their possible implications in strawberry (Fragaria x ananassa) browning reactions[Pubmed: 11853507]
    The peroxidase- and polyphenoloxidase-catalyzed oxidations of (+)-catechin yield several products showing different degrees of polymerization, which are apparently responsible for the pigment decay and the associated browning reaction that occurs in processed strawberry fruits and their derived foods. In this work, we have purified both peroxidase and polyphenoloxidase from Oso Grande cv. strawberry fruits, and comparatively analyzed the products of their enzyme-mediated (+)-catechin oxidation. The joint analysis by reversed-phase and size-exclusion HPLC of the (+)-catechin oxidation products obtained with both enzymes indicate that they were qualitatively the same: dehydrodicatechin B4, a (+)-catechin quinone methide, dehydrodicatechin A, a (+)-catechin trimer, and a (+)-catechin oligomer with polymerization degree equal to or greater than 5. The main quantitative differences between the oxidative reactions were the great amount of oligomer formed in the case of the polyphenoloxidase-mediated reaction and the low amount of (+)-catechin reacted in the case of the peroxidase-mediated reaction. One of the possible reasons for such low levels of (+)-catechin consumption in the case of the peroxidase-mediated reaction was the possible inhibition by products of the enzyme-catalyzed oxidation. In fact, the peroxidase-mediated (+)-catechin oxidation was differentially inhibited by dehydrodicatechin A, showing a competitive type inhibition and a k(I) of 6.4 microM. In light of these observations, these results suggest that brown polymer formation, estimated as oligomeric compounds resulting from (+)-catechin oxidation, in strawberries is mainly due to polyphenoloxidase, and although peroxidase also plays an important role, it is apparently auto-regulated by product (dehydrodicatechin A) inhibition.
    Z Naturforsch C J Biosci . Sep-Oct 2007;62(9-10):656-660.
    Evaluation of cytotoxic compounds from calligonum comosum L. growing in Egypt[Pubmed: 18069236]
    Calligonum comosum (Polygonaceae), an Egyptian desert plant, was extracted and fractionated using petroleum ether, methylene chloride, and ethyl acetate. The total methanolic extract and other fractions were tested for their anticancer activity using Ehrlich ascites, brine shrimp and antioxidant assays. Ethyl acetate fraction proved to be the most active in all assays. Eight compounds were isolated, purified, and identified from this fraction as (+)-catechin (1), dehydrodicatechin A (2), kaempferol-3-O-rhamnopyranoside (3), quercitrin (quercetin-3-O-rhamnopyranoside) (4), beta-sitosterol-3-O-glucoside (5), isoquercitrin (quercetin-3-O-glucopyranoside) (6), kaempferol-3-O-glucuronide (7), and mequilianin (quercetin-3-O-glucuronide) (8). All isolated compounds were tested for their cytotoxicity and antioxidant activity. Compound 2 showed the best cytotoxic and antioxidant activity.
    J Sep Sci . 2021 Dec;44(24):4422-4430.
    Isolation and purification of flavonoids from Euonymus alatus by high-speed countercurrent chromatography and neuroprotective effect of rhamnazin-3-O-rutinoside in vitro[Pubmed: 34670011]
    The flavonoids from Euonymus alatus exhibit many biological activities including significant antioxidant, anti-inflammatory, anti-cancer. In this work, a high-speed countercurrent chromatography method for the isolation and purification of flavonoids from crude extracts of Euonymus alatus was established. The effects of several solvent systems on the separation efficiency of target compounds in the extract of Euonymus alatus were studied. The solvent system composed of n-hexane-ethyl acetate-methanol-water at a volume ratio of (3:5:3:5, v/v) was chosen, in which the lower phase was used as the mobile phase at the rotation speed of 800 rpm and flow rate of 2.0 mL/min. The three flavonoids were obtained and identified as patuletin-3-O-rutinoside, rhamnazin-3-O-rutinoside, and dehydrodicatechin A by mass spectroscopy and nuclear magnetic resonance, and the quantities of patuletin-3-O-rutinoside, rhamnazin-3-O-rutinoside, and dehydrodicatechin A were 2.2, 9.7, and 1.8 mg, respectively. The results indicated that high-speed countercurrent chromatography was a simple and efficient method for the isolation and purification of flavonoids from the crude extracts of Euonymus alatus. The cellular antioxidant activity experimental result indicated that rhamnazin-3-O-rutinoside could alleviate H2 O2 -induced oxidative stress.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.7346 mL 8.673 mL 17.3461 mL 34.6921 mL 43.3651 mL
    5 mM 0.3469 mL 1.7346 mL 3.4692 mL 6.9384 mL 8.673 mL
    10 mM 0.1735 mL 0.8673 mL 1.7346 mL 3.4692 mL 4.3365 mL
    50 mM 0.0347 mL 0.1735 mL 0.3469 mL 0.6938 mL 0.8673 mL
    100 mM 0.0173 mL 0.0867 mL 0.1735 mL 0.3469 mL 0.4337 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    芫花酚C; Genkwanol C CFN91962 151283-11-3 C30H22O11 = 558.49 5mg QQ客服:1457312923
    麻黄宁G; Mahuannin G CFN95553 N/A C30H22O10 = 542.5 5mg QQ客服:1413575084
    麻黄宁J; Mahuannin J CFN95533 N/A C30H20O11 = 556.5 5mg QQ客服:1413575084
    Abiesinol B; Abiesinol B CFN95599 1190070-89-3 C30H22O11 = 558.5 5mg QQ客服:215959384
    Abiesinol A; Abiesinol A CFN95600 1190070-88-2 C30H22O11 = 558.5 5mg QQ客服:3257982914
    麻黄宁B; Mahuannin B CFN95554 82796-37-0 C30H24O10 = 544.5 5mg QQ客服:2056216494
    麻黄根素A; Ephedrannin A CFN95579 82001-39-6 C30H20O11 = 556.5 5mg QQ客服:2056216494
    表阿夫儿茶精-(2beta-O->7,4beta->8)-ent-表儿茶素; Epiafzelechin-(2beta-O->7,4beta->8)-ent-epicatechin CFN95598 135820-73-4 C30H24O11 = 560.5 5mg QQ客服:2056216494
    原花青素A2; Procyanidin A2 CFN96491 41743-41-3 C30H24O12 = 576.5 10mg QQ客服:2056216494
    原花青素A1; Procyanidin A1 CFN96495 103883-03-0 C30H24O12 = 576.5 20mg QQ客服:215959384

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