| Description: |
Dehydrocorydaline has antitumor activity, it inhibits MCF-7 cell proliferation by inducing apoptosis mediated by regulating Bax/Bcl-2, activating caspases as well as cleaving PARP. Dehydrocorydaline inhibits the elevation of mitochondrial membrane potential and induces ATP depletion in LPS-stimulated macrophages but neither affects basal mitochondrial membrane potential nor ATP content in non-stimulated macrophages. |
| Targets: |
Bcl-2/Bax | Caspase | IL Receptor | PARP | cAMP | PGE |
| In vitro: |
| Org Biomol Chem. 2009 Jul 7;7(13):2699-703. | | Selective binding and highly sensitive fluorescent sensor of palmatine and dehydrocorydaline alkaloids by cucurbit[7]uril.[Pubmed: 19532985] |
METHODS AND RESULTS:
The complexation behavior of palmatine (P) and Dehydrocorydaline (DHC) alkaloid guest molecules by cucurbit[7]uril (CB7) host have been investigated by means of fluorescence spectra in aqueous phosphate buffer solution (pH 7.2). It is found that each alkaloid exhibits dramatic fluorescence enhancement upon complexation with CB7, and the intensity of the emittance is strong enough to be readily distinguished by the naked eye. Although the two guests possess similar structure, the complex stability constant of P with CB7 is 5.4 times larger than that of DHC.
CONCLUSIONS:
1H NMR studies show that the binding modes differ much, i.e., deep encapsulation for P-CB7 and shallow encapsulation for Dehydrocorydaline-CB7. Furthermore, the solvent effects and salt effects during the course of complexation have also been investigated, showing they significantly influence the binding ability and selectivity of CB7 with the alkaloid guests. Particularly, addition of a small amount (4 vol%) of ethanol increases the P/Dehydrocorydaline selectivity to 17.2. |
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| In vivo: |
| Molecules. 2012 Jan 18;17(1):951-70. | | Effect of wine and vinegar processing of Rhizoma Corydalis on the tissue distribution of tetrahydropalmatine, protopine and dehydrocorydaline in rats.[Pubmed: 22258341] | Abstract Vinegar and wine processing of medicinal plants are two traditional pharmaceutical techniques which have been used for thousands of years in China. Tetrahydropalmatine (THP), Dehydrocorydaline (DHC) and protopine are three major bioactive molecules in Rhizoma Corydalis.
METHODS AND RESULTS:
In this study, a simple and reliable HPLC method was developed for simultaneous analysis of THP, Dehydrocorydaline and protopine in rat tissues after gastric gavage administration of Rhizoma Corydalis. The validated HPLC method was successfully applied to investigate the effect of wine and vinegar processing on the compounds' distribution in rat tissues. Our results showed that processing mainly affect the T(max) and mean residence time (MRT) of the molecules without changing their C(max) and AUC(0-24)( )(h) Vinegar processing significantly increased the T(max) of Dehydrocorydaline in heart, kidney, cerebrum, cerebrellum, brain stem and striatum and prolonged the T(max) of protopine in brain. No significant changes were observed on the T(max) of THP in rat tissues after vinegar processing. Wine processing reduced the T(max) of protopine and Dehydrocorydaline in liver and spleen and T(max) of protopine in lung, but increased the T(max) of THP in all the rat tissues examined.
CONCLUSIONS:
To our knowledge, this is the first report on the effects of processing on the tissue distribution of the bioactive molecules from Rhizoma Corydalis. |
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