脱水穿心莲内酯琥珀酸半酯

Dehydroandrographolide succinate

	产品编号	CFN91114
	CAS编号	786593-06-4
	分子式 = 分子量	C₂₈H₃₆O₁₀ = 532.59
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The herbs of Andrographis paniculata
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
脱水穿心莲内酯琥珀酸半酯	CFN91114	786593-06-4	10mg	QQ客服：2056216494
脱水穿心莲内酯琥珀酸半酯	CFN91114	786593-06-4	20mg	QQ客服：2056216494
脱水穿心莲内酯琥珀酸半酯	CFN91114	786593-06-4	50mg	QQ客服：2056216494
脱水穿心莲内酯琥珀酸半酯	CFN91114	786593-06-4	100mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universidad de Antioquia (Colombia)

Guangzhou Institutes of Biomedicine and Health (China)

Universiti Kebangsaan Malaysia (Malaysia)

Instituto de Investigaciones Agropecuarias (Chile)

University of Leipzig (Germany)

Wroclaw Medical University (Poland)

National Cancer Center Research Institute (Japan)

University of Mysore (India)

Copenhagen University (Denmark)

Universitas Airlangga (Indonesia)

Kyoto University (Japan)

Auburn University (USA)

S.N.D.T. Women's University (India)

Kitasato University (Japan)

More...

Description:

Dehydroandrographolide succinate can alleviate oxidative stress in LPS-induced acute lung injury possibly by inactivating iNOS. It combined with ribavirin treatedchildren with hand-foodand mouth disease,the duration of fever was shorter,rashes on hands and feet more quickyly.

Targets:

NOS | TNF-α | IL recepter | SOD | Antifection

In vivo:

Anhui Medical Journal, 2010.

Therapeutic effects of dehydroandrographolide succinate combined with ribavirin on children with hand-foot-and-mouth disease[Reference: WebLink]

To evaluate the therapeutic effects of dehydroandrographolide succinate and ribavirin on children with the early severe tendencies of hand-foot-and-mouth disease.
METHODS AND RESULTS:
Children(46 cases) with the early tendencies of hand-foot-and-mouth disease were divided randomly into two groups.All cases received ribavirin and therapies based on their symptoms,while the treatment group of 23 children received dehydroandrographolide succinate(10 mg.kg-1.d-1) for 5 days.Clinical symptom regression time or recovery time in two groups were observed after treatments. All children were recovered after treatments and no case develop into neurogenic pulmonary edema or cardiopulmonary collapse.The duration of fever was shorter in the treatment group;rashes on hands and feet faded more quickly than those of the control group.The difference between the two groups had statistical significance.However,there was no statistically significant differences between the two groups as for the time of mental improvement,disappearance of body shaking and hospital stay time.
CONCLUSIONS:
Dehydroandrographolide succinate combined with ribavirin treatedchildren with hand-foodand mouth disease,the duration of fever was shorter,rashes on hands and feet more quickyly.

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.8776 mL	9.3881 mL	18.7762 mL	37.5523 mL	46.9404 mL
5 mM	0.3755 mL	1.8776 mL	3.7552 mL	7.5105 mL	9.3881 mL
10 mM	0.1878 mL	0.9388 mL	1.8776 mL	3.7552 mL	4.694 mL
50 mM	0.0376 mL	0.1878 mL	0.3755 mL	0.751 mL	0.9388 mL
100 mM	0.0188 mL	0.0939 mL	0.1878 mL	0.3755 mL	0.4694 mL