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  • De-O-methyllasiodiplodin

    De-O-methyllasiodiplodin

    De-O-methyllasiodiplodin
    产品编号 CFN96880
    CAS编号 32885-82-8
    分子式 = 分子量 C16H22O4 = 278.34
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Phenols
    植物来源 The rhizomes of Smilax glabra.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    De-O-methyllasiodiplodin CFN96880 32885-82-8 1mg QQ客服:215959384
    De-O-methyllasiodiplodin CFN96880 32885-82-8 5mg QQ客服:215959384
    De-O-methyllasiodiplodin CFN96880 32885-82-8 10mg QQ客服:215959384
    De-O-methyllasiodiplodin CFN96880 32885-82-8 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
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  • University of Wuerzburg (Germany)
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  • University of Hull (United Kingdom)
  • Univerzita Karlova v Praze (Czech Republic)
  • National Cancer Center Research Institute (Japan)
  • Technical University of Denmark (Denmark)
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  • Griffith University (Australia)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Pharm Biomed Anal2016, 118:183-194
  • JAOCS2021, 98(7):779-794.
  • Plant Physiol Biochem.2019, 144:355-364
  • In Vitro Cellular & Developmental Biology - Plant2022, 58:972-988.
  • Korean J. Food Sci. & Technol.2022, 54(2):241-246
  • J Ethnopharmacol.2020, 269:113752.
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  • J Breast Cancer.2015, 18(2):112-118
  • Processes2020, 8(12),1540.
  • Biochem Pharmacol.2017, 130:10-20
  • Int J Mol Sci.2023, 24(8):7300.
  • Pharmaceutics.2020, 12(9):845.
  • Drug Chem Toxicol.2020, 1-12.
  • Molecules.2019, 24(20):3755
  • Sci Rep.2016, 6:25094
  • Tissue Cell.2022, 75:101728.
  • Evid Based Complement Alternat Med.2018, 2018:4580627
  • Int Immunopharmacol.2023, 125:111175.
  • Pathogens.2018, 7(3):E62
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  • Cell Rep.2020, 32(11):108158.
  • ...
  • 生物活性
    Description: De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on induced NO production. De-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice possibly via ameliorating the expression of obesity-related pro-inflammatory cytokines, highlighting the potential of the marine natural product as a drug lead for the treatment of metabolic disorders.
    Targets: IL Receptor | TNF-α | ROS | NO | Antifection
    In vivo:
    Acta Pharmacol Sin. 2013 Oct;34(10):1325-36.
    Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation.[Pubmed: 23852084 ]
    des-O-methyllasiodiplodin (De-O-methyllasiodiplodin,DML) from Cerbera manghas has shown antagonistic activity against mineralocorticoid receptor (MR). Considering the involvement of MR in the insulin tolerance, we attempted to investigate the potential of DML in the treatment of type 2 diabetes mellitus (T2DM).
    METHODS AND RESULTS:
    In HepG2 and 3T3-L1 cells, both H2O2 and aldosterone markedly stimulates the expression of MCP-1, TNFα, IL-6, p47 and PU.1 genes. Co-treatment with DML (10 μmol/L) significantly reduced the H2O2- or aldosterone-induced expression of these genes. SPR-based assay confirmed the antagonistic activity of DML against the interaction between SRC-1 and MR-LBD. Furthermore, DML decreased aldosterone-induced MR transcriptional activity in a dose-dependent manner. Downregulation of MR with siRNA in the cells prevented or significantly attenuated aldosterone-stimulated expression of these genes, whereas DML did no longer affect the expression of these genes except that of IL-6. Oral administration of DML effectively reduced the levels of blood glucose and glycosylated hemoglobin (HbA1c) in db/db mice. The treatment also rectified the expression of pro-inflammatory factor and ROS-related genes in db/db mice.
    CONCLUSIONS:
    DML effectively lowers the blood glucose level in db/db mice possibly via ameliorating the expression of obesity-related pro-inflammatory cytokines, highlighting the potential of the marine natural product as a drug lead for the treatment of metabolic disorders.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5927 mL 17.9636 mL 35.9273 mL 71.8546 mL 89.8182 mL
    5 mM 0.7185 mL 3.5927 mL 7.1855 mL 14.3709 mL 17.9636 mL
    10 mM 0.3593 mL 1.7964 mL 3.5927 mL 7.1855 mL 8.9818 mL
    50 mM 0.0719 mL 0.3593 mL 0.7185 mL 1.4371 mL 1.7964 mL
    100 mM 0.0359 mL 0.1796 mL 0.3593 mL 0.7185 mL 0.8982 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    汉黄芩素; Wogonin CFN97089 632-85-9 C16H12O5 = 284.3 20mg QQ客服:2056216494
    Rauvotetraphylline E; Rauvotetraphylline E CFN96746 1422506-53-3 C20H19N2O3 = 335.4 5mg QQ客服:1413575084
    Isosalvipuberulin; Isosalvipuberulin CFN99251 115321-32-9 C20H14O5 = 334.3 5mg QQ客服:215959384
    因香酚; Incensole CFN93208 22419-74-5 C20H34O2 = 306.5 20mg QQ客服:3257982914

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