De-O-methyllasiodiplodin

	产品编号	CFN96880
	CAS编号	32885-82-8
	分子式 = 分子量	C₁₆H₂₂O₄ = 278.34
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Phenols
	植物来源	The rhizomes of Smilax glabra.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
De-O-methyllasiodiplodin	CFN96880	32885-82-8	1mg	QQ客服：1413575084
De-O-methyllasiodiplodin	CFN96880	32885-82-8	5mg	QQ客服：1413575084
De-O-methyllasiodiplodin	CFN96880	32885-82-8	10mg	QQ客服：1413575084
De-O-methyllasiodiplodin	CFN96880	32885-82-8	20mg	QQ客服：1413575084

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Uniwersytet Jagielloński w Krakowie (Poland)

The Ohio State University (USA)

Almansora University (Egypt)

University of Amsterdam (Netherlands)

Indian Institute of Science (India)

Vin?a Institute of Nuclear Sciences (Serbia)

Lund University (Sweden)

Sri Ramachandra University (India)

Kazusa DNA Research Institute (Japan)

Universiti Putra Malaysia(UPM) (Malaysia)

Aarhus University (Denmark)

Florida A&M University (USA)

Periyar University (India)

Ain Shams University (Egypt)

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Description:

De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on induced NO production. De-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice possibly via ameliorating the expression of obesity-related pro-inflammatory cytokines, highlighting the potential of the marine natural product as a drug lead for the treatment of metabolic disorders.

Targets:

IL Receptor | TNF-α | ROS | NO | Antifection

In vivo:

Acta Pharmacol Sin. 2013 Oct;34(10):1325-36.

Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation.[Pubmed: 23852084 ]

des-O-methyllasiodiplodin (De-O-methyllasiodiplodin,DML) from Cerbera manghas has shown antagonistic activity against mineralocorticoid receptor (MR). Considering the involvement of MR in the insulin tolerance, we attempted to investigate the potential of DML in the treatment of type 2 diabetes mellitus (T2DM).
METHODS AND RESULTS:
In HepG2 and 3T3-L1 cells, both H2O2 and aldosterone markedly stimulates the expression of MCP-1, TNFα, IL-6, p47 and PU.1 genes. Co-treatment with DML (10 μmol/L) significantly reduced the H2O2- or aldosterone-induced expression of these genes. SPR-based assay confirmed the antagonistic activity of DML against the interaction between SRC-1 and MR-LBD. Furthermore, DML decreased aldosterone-induced MR transcriptional activity in a dose-dependent manner. Downregulation of MR with siRNA in the cells prevented or significantly attenuated aldosterone-stimulated expression of these genes, whereas DML did no longer affect the expression of these genes except that of IL-6. Oral administration of DML effectively reduced the levels of blood glucose and glycosylated hemoglobin (HbA1c) in db/db mice. The treatment also rectified the expression of pro-inflammatory factor and ROS-related genes in db/db mice.
CONCLUSIONS:
DML effectively lowers the blood glucose level in db/db mice possibly via ameliorating the expression of obesity-related pro-inflammatory cytokines, highlighting the potential of the marine natural product as a drug lead for the treatment of metabolic disorders.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Assamicadine; Assamicadine	CFN00244	126260-96-6	C₁₆H₂₃NO₅ = 309.36	5mg	QQ客服：2159513211
Barbacarpan; Barbacarpan	CFN98069	213912-46-0	C₂₀H₁₈O₄ = 322.4	5mg	QQ客服：1413575084
花柏醇; Chamigrenol	CFN95247	19822-80-1	C₁₅H₂₄O = 220.35	10mg	QQ客服：215959384
堪非醇3-O-(6''-O-乙酰基)葡萄糖甙; 6''-O-Acetylastragalin	CFN99281	118169-27-0	C₂₃H₂₂O₁₂ = 490.4	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5927 mL	17.9636 mL	35.9273 mL	71.8546 mL	89.8182 mL
5 mM	0.7185 mL	3.5927 mL	7.1855 mL	14.3709 mL	17.9636 mL
10 mM	0.3593 mL	1.7964 mL	3.5927 mL	7.1855 mL	8.9818 mL
50 mM	0.0719 mL	0.3593 mL	0.7185 mL	1.4371 mL	1.7964 mL
100 mM	0.0359 mL	0.1796 mL	0.3593 mL	0.7185 mL	0.8982 mL