
De-O-methyllasiodiplodin
De-O-methyllasiodiplodin
产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
De-O-methyllasiodiplodin |
CFN96880 |
32885-82-8 |
1mg |
QQ客服:215959384 |
De-O-methyllasiodiplodin |
CFN96880 |
32885-82-8 |
5mg |
QQ客服:215959384 |
De-O-methyllasiodiplodin |
CFN96880 |
32885-82-8 |
10mg |
QQ客服:215959384 |
De-O-methyllasiodiplodin |
CFN96880 |
32885-82-8 |
20mg |
QQ客服:215959384 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
University of Amsterdam (Netherlands)
Universidad Miguel Hernández (Spain)
Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
Universidad Industrial de Santander (Colombia)
Agricultural Research Organization (ARO) (Israel)
University of British Columbia (Canada)
Florida International University (USA)
Lodz University of Technology (Poland)
Institute of Tropical Disease Universitas Airlangga (Indonesia)
Leibniz Institute of Plant Biochemistry (Germany)
Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
Universit?t Basel (Switzerland)
Cancer Research Initatives Foundation(CARIF) (Malaysia)
Universidade da Beira Interior (Germany)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Description: |
De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on induced NO production. De-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice possibly via ameliorating the expression of obesity-related pro-inflammatory cytokines, highlighting the potential of the marine natural product as a drug lead for the treatment of metabolic disorders.
|
Targets: |
IL Receptor | TNF-α | ROS | NO | Antifection |
In vivo: |
Acta Pharmacol Sin. 2013 Oct;34(10):1325-36. | Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation.[Pubmed: 23852084 ] | des-O-methyllasiodiplodin (De-O-methyllasiodiplodin,DML) from Cerbera manghas has shown antagonistic activity against mineralocorticoid receptor (MR). Considering the involvement of MR in the insulin tolerance, we attempted to investigate the potential of DML in the treatment of type 2 diabetes mellitus (T2DM). METHODS AND RESULTS: In HepG2 and 3T3-L1 cells, both H2O2 and aldosterone markedly stimulates the expression of MCP-1, TNFα, IL-6, p47 and PU.1 genes. Co-treatment with DML (10 μmol/L) significantly reduced the H2O2- or aldosterone-induced expression of these genes. SPR-based assay confirmed the antagonistic activity of DML against the interaction between SRC-1 and MR-LBD. Furthermore, DML decreased aldosterone-induced MR transcriptional activity in a dose-dependent manner. Downregulation of MR with siRNA in the cells prevented or significantly attenuated aldosterone-stimulated expression of these genes, whereas DML did no longer affect the expression of these genes except that of IL-6. Oral administration of DML effectively reduced the levels of blood glucose and glycosylated hemoglobin (HbA1c) in db/db mice. The treatment also rectified the expression of pro-inflammatory factor and ROS-related genes in db/db mice. CONCLUSIONS: DML effectively lowers the blood glucose level in db/db mice possibly via ameliorating the expression of obesity-related pro-inflammatory cytokines, highlighting the potential of the marine natural product as a drug lead for the treatment of metabolic disorders. |
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|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
1 mM |
3.5927 mL |
17.9636 mL |
35.9273 mL |
71.8546 mL |
89.8182 mL |
5 mM |
0.7185 mL |
3.5927 mL |
7.1855 mL |
14.3709 mL |
17.9636 mL |
10 mM |
0.3593 mL |
1.7964 mL |
3.5927 mL |
7.1855 mL |
8.9818 mL |
50 mM |
0.0719 mL |
0.3593 mL |
0.7185 mL |
1.4371 mL |
1.7964 mL |
100 mM |
0.0359 mL |
0.1796 mL |
0.3593 mL |
0.7185 mL |
0.8982 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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