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  • De-O-methyllasiodiplodin

    • De-O-methyllasiodiplodin

    De-O-methyllasiodiplodin

    De-O-methyllasiodiplodin
    		产品编号 CFN96880
    CAS编号 32885-82-8
    分子式 = 分子量 C16H22O4 = 278.34
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Phenols
    植物来源 The rhizomes of Smilax glabra.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    De-O-methyllasiodiplodin CFN96880 32885-82-8 1mg QQ客服：215959384
    De-O-methyllasiodiplodin CFN96880 32885-82-8 5mg QQ客服：215959384
    De-O-methyllasiodiplodin CFN96880 32885-82-8 10mg QQ客服：215959384
    De-O-methyllasiodiplodin CFN96880 32885-82-8 20mg QQ客服：215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Max Rubner-Institut (MRI) (Germany)
  • Universite de Lille1 (France)
  • University of Vienna (Austria)
  • Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)
  • Yale University (USA)
  • Osmania University (India)
  • University of Queensland (Australia)
  • Uniwersytet Gdański (Poland)
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  • Regional Crop Research Institute (Korea)
  • Mendel University in Brno (Czech Republic)
  • Universidade Federal de Santa Catarina (Brazil)
  • University of Indonesia (Indonesia)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Agric Food Chem.2022, 70(51):16176-16187.
  • Sci Rep. 2018, 10590
  • Int J Mol Sci.2020, 21(8):2790.
  • Biomed Chromatogr.2022, 36(11):e5462.
  • University of Stuttgart2021, 11682.
  • Molecules.2021, 26(13):4081.
  • Biomed Pharmacother.2023, 162:114617.
  • Ind Crops Prod.2014, 62:173-178
  • Eur J Pharmacol.2023, 950:175772.
  • J. of Agricultural Science2015, 1916-9760
  • Pharmacol Rep.2022, 74(1):175-188.
  • Front Microbiol.2020, 11:583594.
  • Food Res Int.2022, 157:111397.
  • Chem Biodivers.2023, 20(10):e202300741.
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Oncotarget.2017, 8(64):108006-108019
  • Viruses.2021, 13(11):2118.
  • Polytechnic University of Catalonia2017, 105826
  • Phytother Res.2018, 32(5):923-932
  • Journal of Mushroom2023, 21(4):215-221.
  • Molecules.2020, 25(3):734
  • Food Res Int.2020, 128:108778
  • J Pharm Biomed Anal2016, 118:183-194
  • ...
    • 生物活性
    Description: De-O-methyllasiodiplodin exhibits radical scavenging, moderate antibacterial, and potential anti-inflammatory effects, it shows moderate suppression effects on induced NO production. De-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice possibly via ameliorating the expression of obesity-related pro-inflammatory cytokines, highlighting the potential of the marine natural product as a drug lead for the treatment of metabolic disorders.
    Targets: IL Receptor | TNF-α | ROS | NO | Antifection
    In vivo:
    Acta Pharmacol Sin. 2013 Oct;34(10):1325-36.
    Marine natural product des-O-methyllasiodiplodin effectively lowers the blood glucose level in db/db mice via ameliorating inflammation.[Pubmed: 23852084 ]
    des-O-methyllasiodiplodin (De-O-methyllasiodiplodin,DML) from Cerbera manghas has shown antagonistic activity against mineralocorticoid receptor (MR). Considering the involvement of MR in the insulin tolerance, we attempted to investigate the potential of DML in the treatment of type 2 diabetes mellitus (T2DM).
    METHODS AND RESULTS:
    In HepG2 and 3T3-L1 cells, both H2O2 and aldosterone markedly stimulates the expression of MCP-1, TNFα, IL-6, p47 and PU.1 genes. Co-treatment with DML (10 μmol/L) significantly reduced the H2O2- or aldosterone-induced expression of these genes. SPR-based assay confirmed the antagonistic activity of DML against the interaction between SRC-1 and MR-LBD. Furthermore, DML decreased aldosterone-induced MR transcriptional activity in a dose-dependent manner. Downregulation of MR with siRNA in the cells prevented or significantly attenuated aldosterone-stimulated expression of these genes, whereas DML did no longer affect the expression of these genes except that of IL-6. Oral administration of DML effectively reduced the levels of blood glucose and glycosylated hemoglobin (HbA1c) in db/db mice. The treatment also rectified the expression of pro-inflammatory factor and ROS-related genes in db/db mice.
    CONCLUSIONS:
    DML effectively lowers the blood glucose level in db/db mice possibly via ameliorating the expression of obesity-related pro-inflammatory cytokines, highlighting the potential of the marine natural product as a drug lead for the treatment of metabolic disorders.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.5927 mL 17.9636 mL 35.9273 mL 71.8546 mL 89.8182 mL
    5 mM 0.7185 mL 3.5927 mL 7.1855 mL 14.3709 mL 17.9636 mL
    10 mM 0.3593 mL 1.7964 mL 3.5927 mL 7.1855 mL 8.9818 mL
    50 mM 0.0719 mL 0.3593 mL 0.7185 mL 1.4371 mL 1.7964 mL
    100 mM 0.0359 mL 0.1796 mL 0.3593 mL 0.7185 mL 0.8982 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    脱氧茴香偶姻; Desoxyanisoin CFN90118 120-44-5 C16H16O3 = 256.30 5mg QQ客服：2056216494
    alpha-软脂酸香树精酯; alpha-Amyrin palmitate CFN98210 22255-10-3 C46H80O2 = 665.1 5mg QQ客服：1413575084
    L-天冬酰胺; L-Asparagine CFN70188 70-47-3 C4H8N2O3 = 132.1 20mg QQ客服：2159513211
    D-薄荷醇; D-Menthol CFN98125 15356-60-2 C10H20O = 156.27 20mg QQ客服：2056216494

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