DAPT (GSI-IX)

	产品编号	CFN60023
	CAS编号	208255-80-5
	分子式 = 分子量	C₂₃H₂₆F₂N₂O₄ = 432.46
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

提供自定义包装

产品名称	产品编号	CAS编号	包装	QQ客服
DAPT (GSI-IX)	CFN60023	208255-80-5	1mg	QQ客服：3004468091
DAPT (GSI-IX)	CFN60023	208255-80-5	5mg	QQ客服：3004468091
DAPT (GSI-IX)	CFN60023	208255-80-5	10mg	QQ客服：3004468091
DAPT (GSI-IX)	CFN60023	208255-80-5	20mg	QQ客服：3004468091

存储与注意事项

1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。通常，这些可用于长达两周。使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

3. 需要更多关于溶解度，使用和处理的建议？请发送电子邮件至：service@chemfaces.com

订购流程

1. 在线订购

请联系我们QQ客服

2. 电话订购

请拨打电话：
027-84237683 或 027-84237783

3. 邮件或传真订购

发送电子邮件到: manager@chemfaces.com 或
发送传真到：027-84254680

提供订购信息

为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。

1. 产品编号（CAS No.或产品名称）

2. 发货地址

3. 联系方法 (联系人，电话）

4. 开票抬头 (如果需要发票的客户）

5. 发票地址（发货地址与发票地址不同）

发货时间

1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。

ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Shanghai Institute of Organic Chemistry (China)

University of Hull (United Kingdom)

Semmelweis Unicersity (Hungary)

University of Limpopo (South Africa)

Mendel University in Brno (Czech Republic)

Institute of Pathophysiology Medical University of Vienna (Austria)

Univerzita Karlova v Praze (Czech Republic)

Massachusetts General Hospital (USA)

Yale University (USA)

University of Bonn (Germany)

Korea Institute of Oriental Medicine (Korea)

Research Unit Molecular Epigenetics (MEG) (Germany)

National Research Council of Canada (Canada)

University of Sao Paulo (Brazil)

More...

Description:

DAPT (GSI-IX) is a novel γ-secretase inhibitor, which inhibits Aβ production with IC50 of 20 nM in HEK 293 cells. DAPT enhances the apoptosis of human tongue carcinoma cells and regulates autophagy.

Targets:

γ-secretase | Aβ | Autophagy

In vivo:

Neuroscience,2012 May 17;210:99-109.

The γ-secretase blocker DAPT impairs recovery from lipopolysaccharide-induced inflammation in rat brain.[Pubmed: 22445932]

γ-Secretase is an important contributing enzyme in Alzheimer's disease and is therefore an important therapeutic target. However, the impact of γ-secretase inhibition is not well studied in acute neuroinflammation induced by systemic infection.
METHODS AND RESULTS:
In this study the influence of γ-secretase on the expression of some proinflammatory markers was assessed in the acute phase as well as the subsiding phase of neuroinflammation. Cerebral γ-secretase cleavage activity was measured by a fluorometric assay after lipopolysaccharide (LPS) intraperitoneal administration. Time profiles of TNF-α and COX-II expression were then determined to detect the time points relevant to the maximal inflammatory responses and the subsequent recovery phase. γ-Secretase activity coincident with TNF-α protein expression returned to its basal level till 8-12 h after systemic challenge with low dose LPS while COX-II over expression lasted for 48-72 h later. Pharmacological inhibition of γ-secretase with local or systemic administration of DAPT (N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester) was performed to indicate the results on the developmental and sinking phases of inflammatory responses in 6 and 72 h post LPS respectively. Our results demonstrate that both local and systemic modulation of γ-secretase hyper-activity with DAPT increase the duration of TNF-α, COX-II, and NFκB induction. We consistently found mild augmented apoptosis in animals treated with DAPT as determined by measuring cleaved caspase-3 expression and by TUNEL assay 72 h following LPS injection.
CONCLUSIONS:
These results suggest that γ-secretase modulation interferes with certain immune regulatory pathways which may restrict some inflammatory transcription factors such as NF-κB.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
4'-甲基醚金连木黄酮; 4'-O-Methylochnaflavone	CFN93227	49619-87-6	C₃₁H₂₀O₁₀ = 552.49	5mg	QQ客服：3004468088
牡荆素-2''-O-鼠李糖苷; Vitexin-2''-O-rhamnoside	CFN98177	64820-99-1	C₂₇H₃₀O₁₄ = 578.52	20mg	QQ客服：3004468088
二乙酸山芝烯二醇酯; Serratenediol diacetate	CFN98339	27832-84-4	C₃₄H₅₄O₄ = 526.8	5mg	QQ客服：3004468091
硫酸阿托品; Atropine sulfate	CFN90575	55-48-1	C₁₇H₂₅NO₇S = 387.45	20mg	QQ客服：3004468087

信息支持

公司简介
订购流程
付款方式
退换货政策

ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

联系方式

电机：18607101326
传真：027-84254680
在线QQ: 3004468088
E-Mail：manager@chemfaces.com

湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房

ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3124 mL	11.5618 mL	23.1235 mL	46.2471 mL	57.8088 mL
5 mM	0.4625 mL	2.3124 mL	4.6247 mL	9.2494 mL	11.5618 mL
10 mM	0.2312 mL	1.1562 mL	2.3124 mL	4.6247 mL	5.7809 mL
50 mM	0.0462 mL	0.2312 mL	0.4625 mL	0.9249 mL	1.1562 mL
100 mM	0.0231 mL	0.1156 mL	0.2312 mL	0.4625 mL	0.5781 mL