D(+)-阿拉伯糖醇

D-arabinitol

	产品编号	CFN98779
	CAS编号	488-82-4
	分子式 = 分子量	C₅H₁₂O₅ = 152.1
	产品纯度	>=98%
	物理属性	Cryst.
	化合物类型	Miscellaneous
	植物来源	The barks of Eucommia ulmoides Oliver
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
D(+)-阿拉伯糖醇	CFN98779	488-82-4	10mg	QQ客服：1457312923
D(+)-阿拉伯糖醇	CFN98779	488-82-4	20mg	QQ客服：1457312923
D(+)-阿拉伯糖醇	CFN98779	488-82-4	50mg	QQ客服：1457312923
D(+)-阿拉伯糖醇	CFN98779	488-82-4	100mg	QQ客服：1457312923

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Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
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PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
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PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Stanford University (USA)

Korea Food Research Institute(KFRI) (Korea)

Kyoto University (Japan)

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

University of Auckland (New Zealand)

St. Jude Children Research Hospital (USA)

Heinrich-Heine-University Düsseldorf (Germany)

Massachusetts General Hospital (USA)

Tokyo Woman's Christian University (Japan)

University of Wuerzburg (Germany)

University of Virginia (USA)

Uniwersytet Jagielloński w Krakowie (Poland)

Copenhagen University (Denmark)

Leibniz Institute of Plant Biochemistry (Germany)

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Description:

D-arabinitol is a marker for the diagnosis of disseminated candidiasis and for monitoring response to antifungal therapy.

In vivo:

J Med Vet Mycol. 1994;32(3):205-15.

Serum D-arabinitol measured by automated quantitative enzymatic assay for detection and therapeutic monitoring of experimental disseminated candidiasis: correlation with tissue concentrations of Candida albicans.[Pubmed: 7965491]

In order to further understand serum D-arabinitol (DA) as a marker for the diagnosis of disseminated candidiasis and for monitoring response to antifungal therapy, we studied the serum levels of this Candida carbohydrate metabolite by rapid automated enzymatic assay in rabbits with experimental disseminated candidiasis. As a correction for renal impairment, data were expressed as serum D-arabinitol/creatinine ratio (D-arabinitol/Cr). Serum creatinine concentrations were determined from the same sample with the same instrument, thereby allowing rapid determination of the D-arabinitol/Cr within one laboratory.
METHODS AND RESULTS:
The D-arabinitol/Cr was determined in 321 samples from 132 rabbits. The mean serum D-arabinitol/Cr in 31 normal non-infected rabbits was 1.51 +/- 0.2 microM mg-1 dl-1. Among 84 rabbits with disseminated candidiasis and pre-terminal samples, there was a direct correlation between D-arabinitol/Cr and tissue concentration of Candida albicans (r = 0.80; P < 0.001). A threshold of elevated D-arabinitol/Cr (> or = 3.0 microM mg-1 dl-1) was evident in rabbits with a tissue concentration of C. albicans > or = 3 x 10(4) colony forming units (CFU) g-1. Elevated D-arabinitol/Cr was detected in 48 (89%) of 54 rabbits at a C. albicans tissue concentration of > or = 3 x 10(4) CFU g-1 vs. The relationship between the tissue response to antifungal therapy and change in D-arabinitol/Cr was then further analysed. Ten (91%) of 11 rabbits with a tissue-proven response to antifungal therapy (defined as > or = 10(2)-fold reduction of CFU g-1 in comparison to untreated controls) had a > 50% reduction in elevated D-arabinitol/Cr levels. By comparison, 10 (83%) of 12 treated rabbits with no response to therapy had persistently elevated D-arabinitol/Cr levels (P < 0.001).
CONCLUSIONS:
These findings provide an experimental basis for understanding the patterns of expression of serum D-arabinitol in disseminated candidiasis and further indicate that serial D-arabinitol/Cr measurements may be useful for diagnosis and therapeutic monitoring of disseminated candidiasis.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
N-乙酰神经氨酸; N-Acetylneuraminic acid	CFN90045	131-48-6	C₁₁H₁₉NO₉ = 309.27	20mg	QQ客服：2056216494
甘露醇; D-Mannitol	CFN90046	69-65-8	C₆H₁₄O₆ = 182.17	20mg	QQ客服：215959384
卫矛醇; Dulcitol	CFN80242	608-66-2	C₆H₁₄O₆ = 182.07	5mg	QQ客服：1413575084
蒜糖醇; Allitol	CFN98777	488-44-8	C₆H₁₄O₆ = 182.2	5mg	QQ客服：1413575084
D(+)-阿拉伯糖醇; D-arabinitol	CFN98779	488-82-4	C₅H₁₂O₅ = 152.1	20mg	QQ客服：3257982914
硫酸氨基葡萄糖; Glucosamine sulfate	CFN99193	29031-19-4	C₆H₁₅NO₉S = 277.25	20mg	QQ客服：2056216494
木糖醇; Xylitol	CFN99510	87-99-0	C₅H₁₂O₅ = 152.15	20mg	QQ客服：1457312923
赤藓糖醇; Erythritol	CFN99620	149-32-6	C₄H₁₀O₄ = 122.1	20mg	QQ客服：215959384
D-甘露糖; D-Mannose	CFN91717	3458-28-4	C₆H₁₂O₆ = 180.16	20mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.5746 mL	32.8731 mL	65.7462 mL	131.4924 mL	164.3655 mL
5 mM	1.3149 mL	6.5746 mL	13.1492 mL	26.2985 mL	32.8731 mL
10 mM	0.6575 mL	3.2873 mL	6.5746 mL	13.1492 mL	16.4366 mL
50 mM	0.1315 mL	0.6575 mL	1.3149 mL	2.6298 mL	3.2873 mL
100 mM	0.0657 mL	0.3287 mL	0.6575 mL	1.3149 mL	1.6437 mL