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  • D-氨基葡萄糖盐酸盐

    D-Glucosamine hydrochloride

    D-氨基葡萄糖盐酸盐
    产品编号 CFN99194
    CAS编号 66-84-2
    分子式 = 分子量 C6H13NO5.HCl = 215.63
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 Present in mucopolysaccharides and in polysaccharides found in bacteria, fungi, higher plants
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    D-氨基葡萄糖盐酸盐 CFN99194 66-84-2 10mg QQ客服:2056216494
    D-氨基葡萄糖盐酸盐 CFN99194 66-84-2 20mg QQ客服:2056216494
    D-氨基葡萄糖盐酸盐 CFN99194 66-84-2 50mg QQ客服:2056216494
    D-氨基葡萄糖盐酸盐 CFN99194 66-84-2 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Charles Sturt University (Denmark)
  • University of Maryland (USA)
  • Universiti Malaysia Pahang (Malaysia)
  • Instituto Politécnico de Bragan?a (Portugal)
  • Chulalongkorn University (Thailand)
  • University of East Anglia (United Kingdom)
  • Center for protein Engineering (CIP) (Belgium)
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  • University of Toronto (Canada)
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  • Massachusetts General Hospital (USA)
  • Nanjing University of Chinese Medicine (China)
  • Wroclaw Medical University (Poland)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • VNU J of Science: Med.&Pharm. Sci.2023, 39(1):20-29.
  • Exp Biol Med (Maywood).2019, 244(18):1665-1679
  • Appl. Sci. 2021, 11(8),3437.
  • J Appl Pharm Sci.2022, 12(04):044-053
  • New Zealand J. Forestry Sci.2014, 44:17
  • Fitoterapia.2022, 105141.
  • Univerzita Karlova2021, 20.500.11956.
  • Biochem Pharmacol.2023, 211:115502.
  • Pharmaceutics.2023, 15(6):1771.
  • Theranostics.2023, 13(9):3103-3116.
  • HIV Med.2021, 22(8):690-704.
  • Phytomedicine.2021, 84:153501.
  • J Agric Food Chem.2021, 69(14):4210-4222.
  • Journal of Holistic Integrative Pharmacy2024, 5(1):45-55.
  • Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
  • Microb Biotechnol.2021, 14(5):2009-2024.
  • Int J Mol Sci.2021, 22(19):10220.
  • Daru.2022, 30(2):273-288.
  • J Appl Microbiol.2022, 132(2):949-963.
  • Chinese Pharmaceutical Journal2023, 58(2):178-187.
  • FEBS Lett.2015, 589(1):182-7
  • Int Immunopharmacol. 2020, 83:106403.
  • Journal of Apiculture2023.38(3):249-254.
  • ...
  • 生物活性
    Description: D-glucosamine hydrochloride has antimicrobial effect on the common 21 strains of food spoilage microorganisms, it could as preservative agent was used to preserve nature eleo juice. D-glucosamine hydrochloride also has antitumor, antiinflammaty, and anti-arthritis effects, it induces cell apoptosis by blocking of cell-cycle.
    Targets: TGF-β/Smad | TNF-α | COX | NOS | IL Receptor | Calcium Channel
    In vitro:
    Chinese Journal of Marine Drugs, 2008, 27(6):20-5.
    Effects of D-glucosamine hydrochloride on the cell-cycle and expression of proteins in gastric carcinoma cell SGC-7901[Reference: WebLink]
    To study the effects of D-Glucosamine hydrochloride on the apoptosis of gastric carcinoma cell line SGC-7901 and its mechanism.
    METHODS AND RESULTS:
    SRB assay was used to examine the effects of D-Glucosamine hydrochloride on the growth inhibition of SGC-7901.The cell-cycle and expression of cytochrome-C were observed by flow cytometry,the concentrations of intracellular Ca2+ was determined by CLSM and the expressions of cyclinB1,calcinerin were investigated by Western-Blot. D-Glucosamine hydrochloride could block SGC-7901 cell-cycle at S phase of cell division,increase the concentration of intracellular Ca2+ and decrease the expression of cyclinB1,the expressions of calcinerin and cytochrome-c were increased respectively.
    CONCLUSIONS:
    Block of cell-cycle may be one of the mechanism of inducing cell apoptosis by D-Glucosamine hydrochloride.
    Fisheries Science, 2001, 18(2):14-5.
    Studies on Antimicrobial Effects of D-glucosamine Hydrochloride.[Reference: WebLink]
    The antimicrobial effect of D-Glucosamine hydrochloride(GAH)was investigated.
    METHODS AND RESULTS:
    It was found that GAH had antimicrobial effects on the common 21 strains of food spoilage microorganisms.The minimal inhibition concentration is 0 5 g/L,for mould is 2 g/L,for yeast is 1 g/L.In addition,it showed better preservation effect while GAH as preservative agent was used to preserve nature eleo juice.
    In vivo:
    Mar Drugs. 2012 Aug;10(8):1873-82.
    Metabolomic analyses of blood plasma after oral administration of D-glucosamine hydrochloride to dogs.[Pubmed: 23015778 ]

    METHODS AND RESULTS:
    D-Glucosamine hydrochloride (GlcN∙HCl) is an endogenous amino monosaccharide synthesized from glucose that is useful in the treatment of joint diseases in both humans and animals. The aim of this study was to examine amino acid metabolism in dogs after oral administration of GlcN∙HCl. Accelerated fumarate respiration and elevated plasma levels of lactic acid and alanine were observed after administration.
    CONCLUSIONS:
    These results suggest that oral administration of GlcN∙HCl induces anaerobic respiration and starvation in cells, and we hypothesize that these conditions promote cartilage regeneration. Further studies are required to evaluate the expression of transforming growth factor-beta (TGF-β).
    Phytother Res. 2014 Jul;28(7):1054-63
    Effect of fucoxanthin alone and in combination with D-glucosamine hydrochloride on carrageenan/kaolin-induced experimental arthritis in rats.[Pubmed: 24338843]
    The objective of the present study was to investigate the effect of the fucoxanthin (FUCO) alone and in combination with glucosamine hydrochloride (GAH) on carrageenan/kaolin-induced inflammatory arthritis model in rats and to explore its underlying mechanisms.
    METHODS AND RESULTS:
    Joint swelling, muscle weight ratio (%), histopathological examination and scoring, and proteoglycan degradation were examined. Pro-inflammatory interleukin (IL-1β) and tumor necrosis (TNF-α) levels, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase(iNOS) protein expression and nitric oxide (NO) level in knee synovial tissue extract were analyzed using enzyme-linked immunosorbent assay, western blotting analysis, and Griess reagent assay, respectively. FUCO and FUCO + GAH not only may significantly reduce degrees of knee joint swelling and prevent against muscle atrophy, but also may significantly attenuate inflammation in synovial tissue, cartilage erosion, and proteoglycan loss. The efficacies of FUCO + GAH were stronger than that of GAH or FUCO. FUCO alone and FUCO + GAH can significantly inhibit upregulation of COX-2 and iNOS protein expressions, decrease of IL-1β and TNF-α levels, and reduce NO production in knee synovial tissue extract.
    CONCLUSIONS:
    These results indicated that FUCO is an effective anti-arthritis agent through an antiinflammation mechanism. FUCO may enhance therapeutic effect of GAH on rat arthritis through mechanism of antiinflammation.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.6376 mL 23.1879 mL 46.3757 mL 92.7515 mL 115.9393 mL
    5 mM 0.9275 mL 4.6376 mL 9.2751 mL 18.5503 mL 23.1879 mL
    10 mM 0.4638 mL 2.3188 mL 4.6376 mL 9.2751 mL 11.5939 mL
    50 mM 0.0928 mL 0.4638 mL 0.9275 mL 1.855 mL 2.3188 mL
    100 mM 0.0464 mL 0.2319 mL 0.4638 mL 0.9275 mL 1.1594 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    D-(+)-木糖; D-(+)-Xylose CFN99911 58-86-6 C5H10O5 = 150.13 20mg QQ客服:3257982914
    1,5-酐-D-山梨糖醇; 1,5-Anhydro-D-glucitol CFN90078 154-58-5 C6H12O5 = 164.16 5mg QQ客服:2159513211
    果糖; Fructose CFN98121 57-48-7 C6H12O6 = 180.16 20mg QQ客服:1413575084
    1,2-O-异亚丙基-beta-D-吡喃果糖; 1,2-O-Isopropylidene-beta-D-fructopyranose CFN97141 66900-93-4 C9H16O6 = 220.2 5mg QQ客服:1457312923
    1,2:4,5-Di-O-isopropylidene-beta-D-fructopyranose; 1,2:4,5-Di-O-isopropylidene-beta-D-fructopyranose CFN98273 25018-67-1 C12H20O6 = 260.3 5mg QQ客服:1413575084
    α-鼠李糖; alpha-L-Rhamnose CFN90450 3615-41-6 C6H12O5 = 164.16 20mg QQ客服:2159513211
    鼠李糖; L-Rhamnose CFN99545 6155-35-7 C6H14O6 = 182.17 20mg QQ客服:1413575084
    D-(+)岩藻糖; D-(+)-Fucose CFN90954 3615-37-0 C6H12O5 = 164.16 20mg QQ客服:1413575084
    D(+)-无水葡萄糖; D-(+)-Glucose CFN99769 50-99-7 C6H12O6 = 180.16 20mg QQ客服:2159513211
    葡萄糖醛酸; Glucuronic acid CFN91487 6556-12-3 C6H10O7 = 194.1 20mg QQ客服:3257982914

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