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  • 环(脯氨酸-缬氨酸)二肽

    Cyclo(Pro-Val)

    环(脯氨酸-缬氨酸)二肽
    产品编号 CFN90275
    CAS编号 5654-87-5
    分子式 = 分子量 C10H16N2O2 = 196.25
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 From Penicillium oxalicum.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    环(脯氨酸-缬氨酸)二肽 CFN90275 5654-87-5 1mg QQ客服:215959384
    环(脯氨酸-缬氨酸)二肽 CFN90275 5654-87-5 5mg QQ客服:215959384
    环(脯氨酸-缬氨酸)二肽 CFN90275 5654-87-5 10mg QQ客服:215959384
    环(脯氨酸-缬氨酸)二肽 CFN90275 5654-87-5 20mg QQ客服:215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Mysore (India)
  • Charles Sturt University (Denmark)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Worcester Polytechnic Institute (USA)
  • Siksha O Anusandhan University (India)
  • VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
  • Wroclaw Medical University (Poland)
  • Universite Libre de Bruxelles (Belgium)
  • The Ohio State University (USA)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Lodz (Poland)
  • University of Sao Paulo (Brazil)
  • Mahatma Gandhi University (India)
  • Hamdard University (India)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2018, 262:78-85
  • Cell Metab.2020, S1550-4131(20)30002-4
  • Food and Agriculture Org. Of the UN2019, 151-160
  • Sci Rep.2019, 9:12132
  • Journal of Functional Foods2017, 30:30-38
  • Int J Mol Sci.2019, 21(1):E265
  • APMIS.2019, 127(10):688-695
  • J Insect Sci.2020, 20(5):18.
  • Evid Based Complement Alternat Med.2017, 2017:9764843
  • Oxid Med Cell Longev.2021, 2021:6647107.
  • The Catharanthus Genome2022,35-83.
  • Plants (Basel).2020, 9(11):1535.
  • Food Chem.2019, 290:286-294
  • Molecules 2021, 26(4),1092.
  • Int J Mol Sci.2021, 22(12):6466.
  • Enzyme and Microbial Technology2022, 110002.
  • Int J Med Sci.2020, 17(5):626-631
  • J of the Korean Society of Food Science and Nutrition2019, 32(2):148-154
  • J Med Food.2019, 22(10):1067-1077
  • J Chromatogr B Analyt Technol Biomed Life Sci.2018, 1080:27-36
  • Front Pharmacol.2021, 12:744624.
  • Plants (Basel).2021, 10(11):2317.
  • Pharmaceuticals (Basel).2021, 14(8):742.
  • ...
  • 生物活性
    Description: Cyclo(Pro-Val) shows cyctoxic, moderate antifungal and weak antitumor activities in vitro, it can inhibit the growth of Bacillus subtilis with the minimal inhibitory concentration (MIC) value of 0.8 g/L. Cyclo(Pro-Val) and cyclo(Pro-Tyr) are toxic to both suspension cells and seedlings of Pinus thunbergii, which may offer some clues to research the mechanism of pine wilt disease caused by pine wood nematode.
    Targets: Antifection
    In vitro:
    Journal of Shenyang Pharmaceutical University, 2007,24(8) :474-8.
    Cyclic dipeptide constituents from the mangrove fungus Penicillium oxalicum(No.092007).[Reference: WebLink]
    To study the metabolites of mangrove fungus Penicillium oxalicum from the south China sea and search for new anti-tumor compounds.
    METHODS AND RESULTS:
    Compounds were isolated by silica gel,ODS column chromatography,Sephadex LH-20 column chromatography and reversed-phase HPLC purification.Structural elucidation was achieved by physico-chemical constants and spectroscopic analysis.MTT assay was used to evaluate the bioactivities in vitro. Six cyclic dipeptides were isolated from the acetone extracts of mycelium of fungus and elucidated as cyclo-(Phe-Ile)(1),cyclo-(Phe-Val)(3),cyclo-(Ile-Leu)(3),cyclo-(Val-Val)(4),Cyclo(Pro-Val)(5),cyclo-(Pro-Gly)(6).Coumpouds 2,3 and 5 could evidently inhibit the growth of cancer cell lines HepG Ⅱ and LNCaP at the concentration of 50 μg·mL-1.
    CONCLUSIONS:
    All of Compounds are obtained from the marine fungus for the fist time.Compounds 2,3 and 5 show cytotoxic activity in vitro.
    Tetrahedron Lett.,2002, 33(51):6545-8.
    Antifungal cyclopeptides from Halobacillus litoralis YS3106 of marine origin.[Reference: WebLink]

    METHODS AND RESULTS:
    Three new cyclopeptides, including halolitoralin A (a cyclic hexapeptide), halolitoralin B and C (two cyclic tetrapeptides), together with three known cyclic dipeptides, Cyclo(Pro-Val), cyclo(Pro-Leu) and cyclo(Ile-Val) were isolated from the ferment broth of a marine sediment-derived Halobacillus litoralis YS3106.
    CONCLUSIONS:
    The cyclopeptides show surprisingly simple architectures with highly repeated residue units, which showed moderate antifungal and weak antitumor activities in vitro.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 5.0955 mL 25.4777 mL 50.9554 mL 101.9108 mL 127.3885 mL
    5 mM 1.0191 mL 5.0955 mL 10.1911 mL 20.3822 mL 25.4777 mL
    10 mM 0.5096 mL 2.5478 mL 5.0955 mL 10.1911 mL 12.7389 mL
    50 mM 0.1019 mL 0.5096 mL 1.0191 mL 2.0382 mL 2.5478 mL
    100 mM 0.051 mL 0.2548 mL 0.5096 mL 1.0191 mL 1.2739 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    环(脯氨酸-亮氨酸)二肽; Cyclo(Pro-Leu) CFN90281 5654-86-4 C11H18N2O2 = 210.27 10mg QQ客服:1148253675
    环(D-亮氨酸-L-脯氨酸)二肽; Cyclo(D-Leu-L-Pro) CFN96128 36238-67-2 C11H18N2O2 = 210.3 10mg QQ客服:2159513211
    环(羟脯氨酸-亮氨酸)二肽; Cyclo(Hpro-Leu) CFN90285 1016899-93-6 C11H18N2O3 = 226.27 10mg QQ客服:2932563308
    环(L-亮氨酸-反-4-羟基-L-脯氨酸); Cyclo(L-Leu-trans-4-hydroxy-L-Pro) CFN96088 115006-86-5 C11H18N2O3 = 226.3 10mg QQ客服:3257982914
    环(脯氨酸-脯氨酸)二肽; Cyclo(Pro-Pro) CFN90270 6708-06-1 C10H14N2O2 = 194.23 10mg QQ客服:2159513211
    环(甘氨酸-L-脯氨酸)二肽; Cyclo(Gly-L-Pro) CFN96160 3705-27-9 C7H10N2O2 = 154.2 10mg QQ客服:2159513211
    环(脯氨酸-丙氨酸)二肽; Cyclo(Pro-Ala) CFN90282 65556-33-4 C8H12N2O2 = 168.20 10mg QQ客服:2159513211
    环(L-丙氨酸-L-脯氨酸); Cyclo(L-Ala-L-Pro) CFN96111 36357-32-1 C8H12N2O2 = 168.2 10mg QQ客服:3257982914
    环(丝氨酸-脯氨酸)二肽; Cyclo(Ser-Pro) CFN91572 1355217-25-2 C8H12N2O3 = 184.2 10mg QQ客服:215959384
    环(脯氨酸-缬氨酸)二肽; Cyclo(Pro-Val) CFN90275 5654-87-5 C10H16N2O2 = 196.25 10mg QQ客服:2932563308

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