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  • 环(苯丙氨酸-缬氨酸)二肽

    Cyclo(Phe-Val)

    环(苯丙氨酸-缬氨酸)二肽
    产品编号 CFN90274
    CAS编号 14474-71-6
    分子式 = 分子量 C14H18N2O2 = 246.31
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 From Penicillium oxalicum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    环(苯丙氨酸-缬氨酸)二肽 CFN90274 14474-71-6 1mg QQ客服:1413575084
    环(苯丙氨酸-缬氨酸)二肽 CFN90274 14474-71-6 5mg QQ客服:1413575084
    环(苯丙氨酸-缬氨酸)二肽 CFN90274 14474-71-6 10mg QQ客服:1413575084
    环(苯丙氨酸-缬氨酸)二肽 CFN90274 14474-71-6 20mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • National Hellenic Research Foundation (Greece)
  • University of Minnesota (USA)
  • University Medical Center Mainz (Germany)
  • Sanford Burnham Medical Research Institute (USA)
  • Korea Institute of Oriental Medicine (Korea)
  • Universitas Airlangga (Indonesia)
  • Kitasato University (Japan)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Siksha O Anusandhan University (India)
  • Universitas islam negeri Jakarta (Indonesia)
  • Institute of Chinese Materia Medica (China)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Hull (United Kingdom)
  • Copenhagen University (Denmark)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Comp. & Mathematical Methods in Med.2022, 5475559.
  • Food Science and Biotechnology2022, 10.1007.
  • Sci Rep.2021, 11(1):14180.
  • Phytother Res.2020, 34(4):788-795.
  • Phytomedicine.2019, 61:152813
  • Journal of Third Military Medical University2018, 40(12):1073-1078
  • Food Res Int.2020, 133:109130.
  • Plant Physiol Biochem.2023, 203:108073.
  • Evidence-based Compl.&Alternative Med.2023, 5417813
  • Research Square2022, rs.3.rs-1948239
  • Foods.2022, 11(6):882.
  • J of Dentistry & Oral Health2019, 2641-1962
  • Biol Pharm Bull.2018, 41(1):65-72
  • Pharmaceuticals (Basel).2021, 14(7):633.
  • Separation Science Plus2022, sscp.202200048.
  • Recent Pat Anticancer Drug Discov.2022, 17(4):416-426.
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Front Immunol. 2020, 11:62.
  • Curr Issues Mol Biol.2023, 45(3):2136-2156.
  • J of Pharmaceutical Analysis2020, doi: 10.1016
  • Int J Mol Med.2016, 37(2):501-8
  • Forensic Sci Int.2022, 341:111475.
  • Environ Toxicol Pharmacol.2019, 66:109-115
  • ...
  • 生物活性
    Description: Cyclo(Phe-Val) is a new cell cycle inhibitor, it shows cyctoxic activity in vitro.
    In vitro:
    Journal of Shenyang Pharmaceutical University, 2007, 24(8):474-8.
    Cyclic dipeptide constituents from the mangrove fungus Penicillium oxalicum[Reference: WebLink]
    To study the metabolites of mangrove fungus Penicillium oxalicum from the south China sea and search for new anti-tumor compounds.
    METHODS AND RESULTS:
    Compounds were isolated by silica gel,ODS column chromatography,Sephadex LH-20 column chromatography and reversed-phase HPLC purification.Structural elucidation was achieved by physico-chemical constants and spectroscopic analysis.MTT assay was used to evaluate the bioactivities in vitro.Six cyclic dipeptides were isolated from the acetone extracts of mycelium of fungus and elucidated as cyclo-(Phe-Ile)(1),cyclo(Phe-Val)(3),cyclo-(Ile-Leu)(3),cyclo-(Val-Val)(4),cyclo-(Pro-Val)(5),cyclo-(Pro-Gly)(6).Coumpouds 2,3 and 5 could evidently inhibit the growth of cancer cell lines HepG Ⅱ and LNCaP at the concentration of 50 μg·mL-1.
    CONCLUSIONS:
    All of Compounds are obtained from the marine fungus for the fist time.Compounds 2,3 and 5 show cytotoxic activity in vitro.
    Journal of Shenyang Pharmaceutical University, 2015 (2):107 -10.
    Cyclic dipeptides as new cell cycle inhibitors produced by Streptomyces flavoretus 18522[Reference: WebLink]
    To find the cell cycle inhibitors from the metabolites of Streptomyces flavoretus 18522.
    METHODS AND RESULTS:
    Activity-guided isolation was performed on the chloroform extract of the fermentation broth and mycelia of Streptomyces flavoretus 18522 by using ts FT210 cells.Compounds were isolated through various chromatoghraphic methods and elucidated by spectroscopic means.The flow cytometry was used to evaluate the cell cycle inhibiting activity of the fractions and compounds. Six cyclic dipeptides were obtained and identified as cyclo(Ala-Leu)(1),cyclo(Ala-Ile)(2),cyclo(Ala-Val)(3),cyclo(Phe-Leu)(4),cyclo(Ala-Pro)(5) and Cyclo(Phe-Val)(6).
    CONCLUSIONS:
    Compounds 1-6 are reported as new cell cycle inhibitors for the first time.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.0599 mL 20.2996 mL 40.5992 mL 81.1985 mL 101.4981 mL
    5 mM 0.812 mL 4.0599 mL 8.1198 mL 16.2397 mL 20.2996 mL
    10 mM 0.406 mL 2.03 mL 4.0599 mL 8.1198 mL 10.1498 mL
    50 mM 0.0812 mL 0.406 mL 0.812 mL 1.624 mL 2.03 mL
    100 mM 0.0406 mL 0.203 mL 0.406 mL 0.812 mL 1.015 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    AZD1480; AZD1480 CFN60233 935666-88-9 C14H14ClFN8 = 348.77 5mg QQ客服:1457312923
    9alpha,13alpha-表二氧基松香-8(14)-烯-18-酸; 9alpha,13alpha-Epidioxyabiet-8(14)-en-18-oic acid CFN97848 116499-73-1 C20H30O4 = 334.45 5mg QQ客服:2159513211
    Orthosiphol A; Orthosiphol A CFN95442 142741-25-1 C38H44O11 = 676.8 5mg QQ客服:1457312923
    对羟基苯甲醇; 4-Hydroxybenzyl alcohol CFN97071 623-05-2 C7H8O2 = 124.1 20mg QQ客服:2056216494

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