环(L-丙氨酸-L-脯氨酸)

Cyclo(L-Ala-L-Pro)

	产品编号	CFN96111
	CAS编号	36357-32-1
	分子式 = 分子量	C₈H₁₂N₂O₂ = 168.2
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	From Phellinus igniarius.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
环(L-丙氨酸-L-脯氨酸)	CFN96111	36357-32-1	1mg	QQ客服：215959384
环(L-丙氨酸-L-脯氨酸)	CFN96111	36357-32-1	5mg	QQ客服：215959384
环(L-丙氨酸-L-脯氨酸)	CFN96111	36357-32-1	10mg	QQ客服：215959384
环(L-丙氨酸-L-脯氨酸)	CFN96111	36357-32-1	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universidade Federal de Pernambuco (UFPE) (Brazil)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

Center for protein Engineering (CIP) (Belgium)

Sant Gadge Baba Amravati University (India)

Warszawski Uniwersytet Medyczny (Poland)

University of Leipzig (Germany)

National Research Council of Canada (Canada)

Universidade Federal de Santa Catarina (Brazil)

University of Melbourne (Australia)

Medizinische Universit?t Wien (Austria)

University of Illinois (USA)

University of Medicine and Pharmacy (Romania)

Universidade da Beira Interior (Germany)

Chang Gung University (Taiwan)

More...

Description:

Cyclo(L-Ala-L-Pro) and cyclo(L-Val-L-Pro) inhibit aflatoxin production of Aspergillus parasiticus and Aspergillus flavus in liquid medium at concentrations of several hundred uM without affecting fungal growth.

Targets:

Antifection

In vitro:

Microbiology. 2013 May;159(Pt 5):902-12.

Prevention of aflatoxin contamination by a soil bacterium of Stenotrophomonas sp. that produces aflatoxin production inhibitors.[Pubmed: 23449921]

A soil bacterium, designated strain no. 27, was found to produce aflatoxin-production inhibitors. The strain was identified as a species of the genus Stenotrophomonas, and was found to be closely related to Stenotrophomonas rhizophila.
METHODS AND RESULTS:
Two diketopiperazines, cyclo(L-Ala-L-Pro) and cyclo(L-Val-L-Pro), were isolated from the bacterial culture filtrate as main active components. These compounds inhibited aflatoxin production of Aspergillus parasiticus and Aspergillus flavus in liquid medium at concentrations of several hundred μM without affecting fungal growth. Both inhibitors inhibited production of norsorolinic acid, a biosynthetic intermediate involved in an early step of the aflatoxin biosynthetic pathway, and reduced the mRNA level of aflR, which is a gene encoding a key regulatory protein necessary for the expression of aflatoxin-biosynthetic enzymes. These results indicated that the inhibitors targets are present in early regulatory steps leading to AflR expression. Co-culture of strain no. 27 with aflatoxigenic fungi in liquid medium effectively suppressed aflatoxin production of the fungus without affecting fungal growth. Furthermore, application of the bacterial cells to peanuts in laboratory experiments and at a farmer's warehouse in Thailand by dipping peanuts in the bacterial cell suspension strongly inhibited aflatoxin accumulation. The inhibitory effect was dependent on bacterial cell numbers.
CONCLUSIONS:
These results indicated that strain no. 27 may be a practically effective biocontrol agent for aflatoxin control.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
环(L-亮氨酸-反-4-羟基-L-脯氨酸); Cyclo(L-Leu-trans-4-hydroxy-L-Pro)	CFN96088	115006-86-5	C₁₁H₁₈N₂O₃ = 226.3	10mg	QQ客服：2159513211
环(脯氨酸-脯氨酸)二肽; Cyclo(Pro-Pro)	CFN90270	6708-06-1	C₁₀H₁₄N₂O₂ = 194.23	10mg	QQ客服：1413575084
环(甘氨酸-L-脯氨酸)二肽; Cyclo(Gly-L-Pro)	CFN96160	3705-27-9	C₇H₁₀N₂O₂ = 154.2	10mg	QQ客服：215959384
环(脯氨酸-丙氨酸)二肽; Cyclo(Pro-Ala)	CFN90282	65556-33-4	C₈H₁₂N₂O₂ = 168.20	10mg	QQ客服：1413575084
环(L-丙氨酸-L-脯氨酸); Cyclo(L-Ala-L-Pro)	CFN96111	36357-32-1	C₈H₁₂N₂O₂ = 168.2	10mg	QQ客服：2056216494
环(丝氨酸-脯氨酸)二肽; Cyclo(Ser-Pro)	CFN91572	1355217-25-2	C₈H₁₂N₂O₃ = 184.2	10mg	QQ客服：2056216494
环(脯氨酸-缬氨酸)二肽; Cyclo(Pro-Val)	CFN90275	5654-87-5	C₁₀H₁₆N₂O₂ = 196.25	10mg	QQ客服：215959384
环(D-缬氨酸-L-脯氨酸); Cyclo(D-Val-L-Pro)	CFN96114	27483-18-7	C₁₀H₁₆N₂O₂ = 196.3	10mg	QQ客服：2159513211
环(羟脯氨酸-缬氨酸)二肽; Cyclo(Hyp-Val)	CFN91062	1425501-89-8	C₁₀H₁₆N₂O₃ = 212.2	10mg	QQ客服：215959384
环(脯氨酸-亮氨酸)二肽; Cyclo(Pro-Leu)	CFN90281	5654-86-4	C₁₁H₁₈N₂O₂ = 210.27	10mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.9453 mL	29.7265 mL	59.453 mL	118.9061 mL	148.6326 mL
5 mM	1.1891 mL	5.9453 mL	11.8906 mL	23.7812 mL	29.7265 mL
10 mM	0.5945 mL	2.9727 mL	5.9453 mL	11.8906 mL	14.8633 mL
50 mM	0.1189 mL	0.5945 mL	1.1891 mL	2.3781 mL	2.9727 mL
100 mM	0.0595 mL	0.2973 mL	0.5945 mL	1.1891 mL	1.4863 mL