环(L-丙氨酸-L-脯氨酸)
Cyclo(L-Ala-L-Pro)
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 环(L-丙氨酸-L-脯氨酸) |
CFN96111 |
36357-32-1 |
1mg |
QQ客服：2159513211 |
| 环(L-丙氨酸-L-脯氨酸) |
CFN96111 |
36357-32-1 |
5mg |
QQ客服：2159513211 |
| 环(L-丙氨酸-L-脯氨酸) |
CFN96111 |
36357-32-1 |
10mg |
QQ客服：2159513211 |
| 环(L-丙氨酸-L-脯氨酸) |
CFN96111 |
36357-32-1 |
20mg |
QQ客服：2159513211 |
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IF=36.216(2019)PMID: 29328914
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国外学术期刊发表的引用ChemFaces产品的部分文献
Pharmaceuticals.2022, 15(4), 402.
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Cytotechnology.2017, 69(5):765-773
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Front Pharmacol.2021, 12:607403.
Foods.2022, 11(12):1708.
Research Square2023, 2883170.
Appl. Sci. 2021, 11(17),7829
| Description: |
Cyclo(L-Ala-L-Pro) and cyclo(L-Val-L-Pro) inhibit aflatoxin production of Aspergillus parasiticus and Aspergillus flavus in liquid medium at concentrations of several hundred uM without affecting fungal growth. |
| Targets: |
Antifection |
| In vitro: |
| Microbiology. 2013 May;159(Pt 5):902-12. | | Prevention of aflatoxin contamination by a soil bacterium of Stenotrophomonas sp. that produces aflatoxin production inhibitors.[Pubmed: 23449921] | A soil bacterium, designated strain no. 27, was found to produce aflatoxin-production inhibitors. The strain was identified as a species of the genus Stenotrophomonas, and was found to be closely related to Stenotrophomonas rhizophila.
METHODS AND RESULTS:
Two diketopiperazines, cyclo(L-Ala-L-Pro) and cyclo(L-Val-L-Pro), were isolated from the bacterial culture filtrate as main active components. These compounds inhibited aflatoxin production of Aspergillus parasiticus and Aspergillus flavus in liquid medium at concentrations of several hundred μM without affecting fungal growth. Both inhibitors inhibited production of norsorolinic acid, a biosynthetic intermediate involved in an early step of the aflatoxin biosynthetic pathway, and reduced the mRNA level of aflR, which is a gene encoding a key regulatory protein necessary for the expression of aflatoxin-biosynthetic enzymes. These results indicated that the inhibitors targets are present in early regulatory steps leading to AflR expression. Co-culture of strain no. 27 with aflatoxigenic fungi in liquid medium effectively suppressed aflatoxin production of the fungus without affecting fungal growth. Furthermore, application of the bacterial cells to peanuts in laboratory experiments and at a farmer's warehouse in Thailand by dipping peanuts in the bacterial cell suspension strongly inhibited aflatoxin accumulation. The inhibitory effect was dependent on bacterial cell numbers.
CONCLUSIONS:
These results indicated that strain no. 27 may be a practically effective biocontrol agent for aflatoxin control. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
5.9453 mL |
29.7265 mL |
59.453 mL |
118.9061 mL |
148.6326 mL |
| 5 mM |
1.1891 mL |
5.9453 mL |
11.8906 mL |
23.7812 mL |
29.7265 mL |
| 10 mM |
0.5945 mL |
2.9727 mL |
5.9453 mL |
11.8906 mL |
14.8633 mL |
| 50 mM |
0.1189 mL |
0.5945 mL |
1.1891 mL |
2.3781 mL |
2.9727 mL |
| 100 mM |
0.0595 mL |
0.2973 mL |
0.5945 mL |
1.1891 mL |
1.4863 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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