氯化失车菊素-3-O-桑布双糖苷

Cyanidin-3-O-sambubioside chloride

	产品编号	CFN92173
	CAS编号	33012-73-6
	分子式 = 分子量	C₂₆H₂₉ClO₁₅ = 617.0
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The fruits of Vaccinium myrtillus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
氯化失车菊素-3-O-桑布双糖苷	CFN92173	33012-73-6	1mg	QQ客服：2056216494
氯化失车菊素-3-O-桑布双糖苷	CFN92173	33012-73-6	5mg	QQ客服：2056216494
氯化失车菊素-3-O-桑布双糖苷	CFN92173	33012-73-6	10mg	QQ客服：2056216494
氯化失车菊素-3-O-桑布双糖苷	CFN92173	33012-73-6	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Cyanidin-3-O-sambubioside chloride is inhibitors of BPDE-induced NFκB activity. It inhibits the enzyme activity by competing with the substrate for the active site. Cyanidin-3-O-sambubioside chloride has antioxidant activity and free-radical-scavenging property.

Targets:

NF-kB | ROS

In vitro:

J Biomol Struct Dyn . 2018 Dec;36(16):4255-4269.

The inhibitory performance of flavonoid cyanidin-3-sambubiocide against H274Y mutation in H1N1 influenza virus[Pubmed: 29199545]

Abstract Oseltamivir (Tamiflu) is the most accepted antiviral drug that targets the neuraminidase (NA) protein to inhibit the viral release from the host cell. Few H1N1 influenza strains with the H274Y mutation creates drug resistance to oseltamivir. In this study, we report that flavonoid cyanidin-3-sambubiocide (C3S) compound acts as a potential inhibitor against H274Y mutation. The drug resistance mechanism and inhibitory activity of C3S and oseltamivir against wild-type (WT) and H274Y mutant-type (MT) have been studied and compared based on the results of molecular docking, molecular dynamics, and quantum chemical methods. Oseltamivir has been found less binding affinity with MT. C3S has more binding affinity with WT and MT proteins. From the dynamical study, the 150th loop of the MT protein has found more deformation than WT. A single H274Y mutation induces the conformational changes in the 150th loop which leads to produce more resistance to oseltamivir. The 150th cavity is more attractive target for C3S to stop the conformational changes in the MT, than 430th cavity of NA protein. The C3S is stabilized with MT by more number of hydrogen bonds than oseltamivir. The electrostatic interaction energy shows a stronger C3S binding with MT and this compound may be more effective against oseltamivir-resistant virus strains. Keywords: H274Y mutation; Influenza virus; drug resistance; molecular docking; molecular dynamic simulation.

Planta Med . 2013 Nov;79(17):1636-40.

Cyanidin-3-O-sambubioside from Acanthopanax sessiliflorus fruit inhibits metastasis by downregulating MMP-9 in breast cancer cells MDA-MB-231[Pubmed: 24214832]

Abstract Anthocyanins play an important role in physiological functions related to human health. This study aimed to investigate the inhibitory effect of cyanidin-3-O-sambubioside isolated from Acanthopanax sessiliflorus fruit on cancer cell metastasis. The inhibitory effect of cyanidin-3-O-sambubioside on angiogenesis was assessed by chorioallantoic membrane and tube formation assays. Cyanidin-3-O-sambubioside interrupted the formation of neovasculature and tube-like structures in a dose-dependent manner. It inhibited the wound healing migration and invasion of MDA-MB-231 cells through reconstituted extracellular matrix (Matrigel). Gelatin zymography revealed that cyanidin-3-O-sambubioside significantly decreased the secretion of matrix metalloproteinase-9 and inhibited matrix metalloproteinase-9 expression. In additional, cyanidin-3-O-sambubioside exerted an inhibitory effect on Akt phosphorylation. These results suggest that cyanidin-3-O-sambubioside inhibits metastasis processes, such as angiogenesis and invasion, in breast cancer cells through regulation of matrix metalloproteinase-9 activity. Georg Thieme Verlag KG Stuttgart · New York.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
氯化锦葵色素; Malvidin chloride	CFN92035	643-84-5	C₁₇H₁₅ClO₇ = 366.8	10mg	QQ客服：2056216494
氯化锦葵色素-3-O-阿拉伯糖苷; Malvidin-3-O-arabinoside chloride	CFN92050	28500-04-1	C₂₂H₂₃ClO₁₁ = 498.9	5mg	QQ客服：1413575084
氯化锦葵色素-3-O-葡萄糖苷; Malvidin-3-O-glucoside chloride	CFN92049	7228-78-6	C₂₃H₂₅ClO₁₂ = 528.9	10mg	QQ客服：1413575084
氯化锦葵色素-3-O-半乳糖苷; Malvidin-3-O-galactoside chloride	CFN92048	30113-37-2	C₂₃H₂₅ClO₁₂ = 528.9	10mg	QQ客服：2159513211
氯化锦葵色素-3,5-O-双葡萄糖苷; Malvidin-3,5-O-diglucoside chloride	CFN91867	16727-30-3	C₂₉H₃₅ClO₁₇ = 691.0	10mg	QQ客服：2159513211
氯化矮牵牛素; Petunidin chloride	CFN92036	1429-30-7	C₁₆H₁₃ClO₇ = 352.7	5mg	QQ客服：215959384
氯化矮牵牛素-3-O-葡萄糖苷; Petunidin-3-O-glucoside chloride	CFN92043	6988-81-4	C₂₂H₂₃ClO₁₂ = 514.9	5mg	QQ客服：1413575084
氯化矮牵牛素-3-O-半乳糖苷; Petunidin-3-O-galactoside chloride	CFN92042	28500-02-9	C₂₂H₂₃ClO₁₂ = 514.9	5mg	QQ客服：215959384
矮牵牛素-3-O-芸香糖苷(反-对香豆酰)-5-O-葡萄糖苷; Petunidin 3-rutinoside (p-coumarin)-5-glucoside	CFN95660	69915-09-9	C₄₃H₄₉ClO₂₃ = 969.3	10mg	QQ客服：2159513211
氯化天竺葵素; Pelargonidin chloride	CFN92132	134-04-3	C₁₅H₁₁O₅Cl = 306.7	10mg	QQ客服：1413575084

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.6207 mL	8.1037 mL	16.2075 mL	32.4149 mL	40.5186 mL
5 mM	0.3241 mL	1.6207 mL	3.2415 mL	6.483 mL	8.1037 mL
10 mM	0.1621 mL	0.8104 mL	1.6207 mL	3.2415 mL	4.0519 mL
50 mM	0.0324 mL	0.1621 mL	0.3241 mL	0.6483 mL	0.8104 mL
100 mM	0.0162 mL	0.081 mL	0.1621 mL	0.3241 mL	0.4052 mL

氯化失车菊素-3-O-桑布双糖苷

Cyanidin-3-O-sambubioside chloride

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