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  • 木犀草定氯化物

    Luteolinidin chloride

    木犀草定氯化物
    产品编号 CFN91858
    CAS编号 1154-78-5
    分子式 = 分子量 C15H11ClO5 = 306.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The fruits of Vaccinium myrtillus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    木犀草定氯化物 CFN91858 1154-78-5 1mg QQ客服:3257982914
    木犀草定氯化物 CFN91858 1154-78-5 5mg QQ客服:3257982914
    木犀草定氯化物 CFN91858 1154-78-5 10mg QQ客服:3257982914
    木犀草定氯化物 CFN91858 1154-78-5 20mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • MTT Agrifood Research Finland (Finland)
  • Monash University (Australia)
  • Seoul National University of Science and Technology (Korea)
  • Technical University of Denmark (Denmark)
  • Stanford University (USA)
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University of Pretoria (South Africa)
  • Texas A&M University (USA)
  • University of Illinois at Chicago (USA)
  • University of Minnesota (USA)
  • Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
  • Anna University (India)
  • Massachusetts General Hospital (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Kor. J. Herbol.2019, 34(2):59-66
  • BMC Plant Biol.2020, 20(1):214.
  • Asian Pac J Cancer Prev.2021, 22(S1):97-106.
  • Int Immunopharmacol.2019, 71:22-31
  • Mutlu Yanic S, Ates EG. JOTCSA.2023, 10(4);893-902.
  • World J Mens Health.2019, 10.5534
  • Int J Mol Sci.2022, 23(23):15213.
  • Front Plant Sci.2018, 9:1424
  • Hum Exp Toxicol.2017, 36(11):1169-1176
  • Journal of Functional Foods2022, 96: 105216.
  • Life Sci.2018, 209:498-506
  • J Nat Prod.2021, 84(9):2544-2553.
  • Foods.2021, 10(11):2627.
  • Drug Chem Toxicol.2020, 1-12.
  • Pharmacol Rep.2019, 71(2):289-298
  • Kangwon National University2022, 37(1):29-37
  • Molecules.2021, 26(18):5665.
  • Journal of Functional Foods2022, 91:105019.
  • Environ Toxicol.2022, 37(3):514-526.
  • International. J. of Food Properties 2017, 20:S131-S140
  • British Jou. Med.&Med. Research2014, 1802-1811
  • bioRxiv2021, 458409.
  • Food Chem Toxicol.2023, 176:113802.
  • ...
  • 生物活性
    Description: Luteolinidin chloride (100µM) can significantly blunt the effects of NAD on the cellular responses to GD.
    In vitro:
    Journal of Food Biochemistry, 2010, 32(5):576-596.
    Anthocyanin Interactions with DNA: Intercalation, Topoisomerase I Inhibition and Oxidative Reactions.[Pubmed: 19924259]
    Anthocyanins and their aglycone anthocyanidins are pigmented flavonoids found in significant amounts in many commonly consumed foods. They exhibit a complex chemistry in aqueous solution, which makes it difficult to study their chemistry under physiological conditions.
    METHODS AND RESULTS:
    Here we used a gel electrophoresis assay employing supercoiled DNA plasmid to examine the ability of these compounds (1) to intercalate DNA, (2) to inhibit human topoisomerase I through both inhibition of plasmid relaxation activity (catalytic inhibition) and stabilization of the cleavable DNA-topoisomerase complex (poisoning), and (3) to inhibit or enhance oxidative single-strand DNA nicking. We found no evidence of DNA intercalation by anthocyan(id)ins in the physiological pH range for any of the compounds used in this study-cyanidin chloride, cyanidin 3-O-glucoside, cyanidin 3,5-O-diglucoside, malvidin 3-O-glucoside and luteolinidin chloride. The anthocyanins inhibited topoisomerase relaxation activity only at high concentrations (> 50 muM) and we could find no evidence of topoisomerase I cleavable complex stabilization by these compounds. However, we observed that all of the anthocyan(id)ins used in this study were capable of inducing significant oxidative DNA strand cleavage (nicking) in the presence of 1 mM DTT (dithiothreitol), while the free radical scavenger, DMSO, at concentrations typically used in similar studies, completely inhibited DNA nicking.
    CONCLUSIONS:
    Finally, we propose a mechanism to explain the anthocyan(id)in induced oxidative DNA cleavage observed under our experimental conditions.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.2605 mL 16.3026 mL 32.6052 mL 65.2103 mL 81.5129 mL
    5 mM 0.6521 mL 3.2605 mL 6.521 mL 13.0421 mL 16.3026 mL
    10 mM 0.3261 mL 1.6303 mL 3.2605 mL 6.521 mL 8.1513 mL
    50 mM 0.0652 mL 0.3261 mL 0.6521 mL 1.3042 mL 1.6303 mL
    100 mM 0.0326 mL 0.163 mL 0.3261 mL 0.6521 mL 0.8151 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Yunnandaphninine G; Yunnandaphninine G CFN99061 1042143-83-8 C30H47NO3 = 469.7 5mg QQ客服:1413575084
    矮陀陀碱; Axillarine CFN00347 19637-66-2 C18H27NO7 = 369.41 5mg QQ客服:1457312923
    Clemomandshuricoside B; Clemomandshuricoside B CFN95302 905294-48-6 C22H30O13 = 502.2 10mg QQ客服:1413575084
    歪千里光碱; Sceleratine CFN00414 6190-25-6 C18H27NO7 = 369.41 5mg QQ客服:1413575084

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