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  • 氯化失车菊素-3-O-葡萄糖苷

    Cyanidin-3-O-glucoside chloride

    氯化失车菊素-3-O-葡萄糖苷
    产品编号 CFN99740
    CAS编号 7084-24-4
    分子式 = 分子量 C21H21ClO11 = 484.8
    产品纯度 >=98%
    物理属性 Red powder
    化合物类型 Flavonoids
    植物来源 The herbs of Chrysanthemum indicum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    氯化失车菊素-3-O-葡萄糖苷 CFN99740 7084-24-4 10mg QQ客服:2056216494
    氯化失车菊素-3-O-葡萄糖苷 CFN99740 7084-24-4 20mg QQ客服:2056216494
    氯化失车菊素-3-O-葡萄糖苷 CFN99740 7084-24-4 50mg QQ客服:2056216494
    氯化失车菊素-3-O-葡萄糖苷 CFN99740 7084-24-4 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Bonn (Germany)
  • The Vancouver Prostate Centre (VPC) (Canada)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Wageningen University (Netherlands)
  • National Hellenic Research Foundation (Greece)
  • University of Minnesota (USA)
  • University of Virginia (USA)
  • Korea Intitute of Science and Technology (KIST) (Korea)
  • Nanjing University of Chinese Medicine (China)
  • Complutense University of Madrid (Spain)
  • Semmelweis Unicersity (Hungary)
  • Lodz University of Technology (Poland)
  • Worcester Polytechnic Institute (USA)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food and Chemical Toxicology2020, 111221
  • Molecules.2020, 25(11):2599.
  • Toxins (Basel).2023, 15(3):231.
  • Front Pharmacol.2017, 8:673
  • Cell Metab.2020, S1550-4131(20)30002-4
  • J Biochem Mol Toxicol.2021, 35(5):e22731.
  • Int J Oncol.2016, 49(4):1497-504
  • Industrial Crops and Products2018, 353-362
  • Phytomedicine.2018, 38:45-56
  • Environ Toxicol.2023, 23929.
  • Planta Med.2024, 2328-2750
  • J Insect Sci.2020, 20(5):18.
  • JMicrobiol Biotech Food Sci2021, e4289.
  • Russian J Bioorganic Chemistry 2021, 47:1411-1417.
  • Int J Mol Sci.2019, 20(23):E6071
  • Mol Med Rep.2014, 9(5):1653-9
  • Int J Cosmet Sci.2023, 45(2):155-165.
  • Int J Mol Sci.2022, 23(23):14826.
  • Sci Rep.2017, 7:46299
  • Plant Direct.2021, 5(12):e372.
  • Research Square2021, March 3rd.
  • Plant Pathology2022, 13527
  • Enzyme Microb Technol.2022, 161:110111.
  • ...
  • 生物活性
    Description: Cyanidin-3- O -glucoside exhibits strong antioxidant activities, it has protective effects from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure. Cyanidin-3-O-glucoside chloride decreased mutant p21 expression, and increased the ratio of Bax/Bcl-2 and the activation of caspase-3 to induce apoptosis. It has the function of raising blood sugar
    concentration, maintaining the balance of Lipid metabolism and reducing obesity.
    Targets: Bcl-2/Bax | Caspase | p21
    In vitro:
    Life Sci. 2003 Jul 18;73(9):1097-114.
    Protective effects of cyanidin-3-O-glucoside from blackberry extract against peroxynitrite-induced endothelial dysfunction and vascular failure.[Pubmed: 12818719]
    Anthocyanins are a group of naturally occurring phenolic compounds as colorants in several plants, flowers and fruits. These pigments have a great importance as quality indicators, as chemotaxonomic markers and antioxidants.
    METHODS AND RESULTS:
    The content of blackberry (Rubus species) juice was investigated by HPLC/ESI/MS using narrow bore HPLC columns. Using this method we demonstrated that cyanidin-3-O-glucoside represents about 80% of the total anthocyanin contents in blackberry extract. Here we investigated antioxidant activity of the blackberry juice and cyanidin-3-O-glucoside on the endothelial dysfunction in cells and in vascular rings exposed to peroxynitrite. In human umbilical vein endothelial cells (HUVEC) in vitro, peroxynitrite caused a significant suppression of mitochondrial respiration (38 +/- 2.1% of control cells), as measured by the mitochondrial-dependent conversion of the dye MTT to formazan. Peroxynitrite caused DNA strand breakage (63 +/- 1.9% single strand vs 3 +/- 0.9% single strand in control cells), as measured by the alkaline unwinding assay, and caused an activation of PARS, as measured by the incorporation of radiolabeled NAD(+) to nuclear proteins. Blackberry juice (different dilutions that contained 80 ppm;40 ppm;14.5 ppm of cyanidin-3-O-glucoside) and cyanidin-3-O-glucoside (as chloride) (0.085 microM; 0.028 microM; 0.0085 microM) reduced the peroxynitrite-induced suppression of mitochondrial respiration, DNA damage and PARS activation in HUVECs. Vascular rings exposed to peroxynitrite exhibited reduced endothelium-dependent relaxant responses in response to acetylcholine as well as a vascular contractility dysfunction in response to norepinephrine. The development of this peroxynitrite-induced vascular dysfunction was ameliorated by the blackberry juice (different dilutions that contained 80 ppm;40 ppm;14.5 ppm of cyanidin-3-O-glucoside) and cyanidin-3-O-glucoside (as cyanidin-3-O-glucoside chloride) (0.085 microM;0.028 microM;0.0085 microM).
    CONCLUSIONS:
    In conclusion our findings clearly demonstrate that blackberry juice containing cyanidin-3-O-glucoside is a scavenger of peroxynitrite and that exert a protective effect against endothelial dysfunction and vascular failure induced by peroxynitrite.
    Int J Mol Sci. 2016 Jul; 17(7): 993.
    Cytotoxicity and Apoptotic Effects of Polyphenols from Sugar Beet Molasses on Colon Carcinoma Cells in Vitro[Pubmed: 27347927]
    Three polyphenols were isolated and purified from sugar beet molasses by ultrasonic-aid extraction and various chromatographic techniques, and their structures were elucidated by spectral analysis. Cytotoxicity and the molecular mechanism were measured by methyl thiazolyl tetrazolium (MTT) assay, flow cytometry, caspase-3 activity assay and Western blot assay. The results showed that gallic acid, cyanidin-3-O-glucoside chloride and epicatechin have cytotoxicity to the human colon, hepatocellular and breast cancer cells. Cyanidin-3-O-glucoside chloride showed its cytotoxicity against various tumor cell lines, particularly against colon cancer Caco-2 cells with half maximal inhibitory concentration (IC50) value of 23.21 ± 0.14 μg/mL in vitro. Cyanidin-3-O-glucoside chloride may be a potential candidate for the treatment of colon cancer. In the mechanism study, cyanidin-3-O-glucoside chloride increased the ratio of cell cycle at G0/G1 phase and reduced cyclin D1 expression on Caco-2 cells. Cyanidin-3-O-glucoside chloride decreased mutant p21 expression, and increased the ratio of Bax/Bcl-2 and the activation of caspase-3 to induce apoptosis.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.0627 mL 10.3135 mL 20.6271 mL 41.2541 mL 51.5677 mL
    5 mM 0.4125 mL 2.0627 mL 4.1254 mL 8.2508 mL 10.3135 mL
    10 mM 0.2063 mL 1.0314 mL 2.0627 mL 4.1254 mL 5.1568 mL
    50 mM 0.0413 mL 0.2063 mL 0.4125 mL 0.8251 mL 1.0314 mL
    100 mM 0.0206 mL 0.1031 mL 0.2063 mL 0.4125 mL 0.5157 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    氯化飞燕草素-3-O-芸香糖苷; Delphinidin-3-O-rutinoside chloride CFN92136 15674-58-5 C27H31O16Cl = 645.0 5mg QQ客服:2159513211
    氯化飞燕草素-3,5-O-二葡萄糖苷; Delphinidin-3,5-O-diglucoside chloride CFN92137 17670-06-3 C27H31O17Cl = 663.0 5mg QQ客服:2056216494
    氯化飞燕草素-3-O-桑布双糖苷-5-O-葡萄糖苷; Delphinidin-3-O-sambubioside-5-O-glucoside chloride CFN91870 36415-91-5 C32H39ClO21 = 795.1 5mg QQ客服:2159513211
    氯化芍药素; Peonidin chloride CFN92034 134-01-0 C16H13ClO6 = 336.7 5mg QQ客服:2159513211
    氯化芍药素-3-O-阿拉伯糖苷; Peonidin-3-O-arabinoside chloride CFN92047 524943-91-7 C21H21ClO10 = 468.8 5mg QQ客服:2056216494
    氯化芍药素-3-O-半乳糖苷; Peonidin-3-O-galactoside chloride CFN92045 28148-89-2 C22H23ClO11 = 498.9 5mg QQ客服:2056216494
    氯化芍药素-3-O-葡萄糖苷; Peonidin-3-O-glucoside chloride CFN92046 6906-39-4 C22H23ClO11 = 498.9 5mg QQ客服:215959384
    氯化芍药素-3,5-O-双葡萄糖苷; Peonidin-3,5-O-diglucoside chloride CFN91868 132-37-6 C28H33ClO16 = 661.0 5mg QQ客服:215959384
    = 5mg QQ客服:1413575084
    氯化失车菊素-3-O-葡萄糖苷; Cyanidin-3-O-glucoside chloride CFN99740 7084-24-4 C21H21ClO11 = 484.8 20mg QQ客服:1413575084

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