葫芦素 IIa；雪胆素甲

Cucurbitacin IIA

	产品编号	CFN98171
	CAS编号	58546-34-2
	分子式 = 分子量	C₃₂H₅₀O₈ = 562.73
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The rhizomes of Hemsleya amabilis Diels.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
葫芦素 IIa；雪胆素甲	CFN98171	58546-34-2	10mg	QQ客服：2159513211
葫芦素 IIa；雪胆素甲	CFN98171	58546-34-2	20mg	QQ客服：2159513211
葫芦素 IIa；雪胆素甲	CFN98171	58546-34-2	50mg	QQ客服：2159513211
葫芦素 IIa；雪胆素甲	CFN98171	58546-34-2	100mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Limpopo (South Africa)

Subang Jaya Medical Centre (Malaysia)

St. Jude Children Research Hospital (USA)

Lodz University of Technology (Poland)

Sapienza University of Rome (Italy)

Siksha O Anusandhan University (India)

Centralised Purchases Unit (CPU), B.I.T.S (India)

The Vancouver Prostate Centre (VPC) (Canada)

Macau University of Science and Technology (China)

Srinakharinwirot University (Thailand)

Nanjing University of Chinese Medicine (China)

Pennsylvania State University (USA)

Leibniz Institute of Plant Biochemistry (Germany)

Auburn University (USA)

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Description:

Cucurbitacin IIa has anti-cancer, anti-bacterial, and anti-inflammatory effects, it can induce apoptosis and enhance autophagy; it also can disrupt the actin cytoskeleton and direct the cell to undergo PARP-mediated apoptosis through the inhibition of survivin downstream of JAK2/STAT3.

Targets:

In vitro:

Int Immunopharmacol. 2013 May;16(1):27-34.

Cucurbitacin IIa induces caspase-3-dependent apoptosis and enhances autophagy in lipopolysaccharide-stimulated RAW 264.7 macrophages.[Pubmed: 23541744]

Cucurbitacin IIA (CuIIa), a member of cucurbitacin family, is isolated from the root of Hemsleya amabilis which has been used as an ancient remedy for bacillary dysentery and gastroenteritis. The anti-inflammatory properties of Cucurbitacin IIA have long been recognized but the underlying mechanism is largely unknown.
METHODS AND RESULTS:
In this study, we investigated the anti-inflammatory effect of Cucurbitacin IIA on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells. The results showed that Cucurbitacin IIA inhibited the proliferation and migration of RAW 264.7 cells in a dose-dependent manner. Whereas Cucurbitacin IIA did not cause apoptosis in unstimulated RAW 264.7 cells, it did induce a significant apoptosis in LPS-stimulated cells, which was caspase-3-dependent and associated with downregulation of survivin. Furthermore, LPS induced autophagy in RAW 264.7 cells and this effect was further enhanced by Cucurbitacin IIA as evidenced by increased levels of LC3-II conjugates and formation of LC3 puncta. In addition, Cucurbitacin IIA disrupted actin cytoskeleton via inducing actin aggregation. However, neither the synthesis of tumor necrosis factor-α, nor the activation of the mitogen-activated protein kinases and NF-κB pathways in LPS-stimulated cells was suppressed by Cucurbitacin IIA treatment.
CONCLUSIONS:
Collectively, these results suggested that induction of apoptosis and enhancement of autophagy contributed to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
葫芦素R; Cucurbitacin R	CFN92895	55903-92-9	C₃₀H₄₆O₇ = 518.68	5mg	QQ客服：1457312923
二氢葫芦素B; Dihydrocucurbitacin B	CFN92140	13201-14-4	C₃₂H₄₈O₈ = 560.7	10mg	QQ客服：2056216494
法巴森; Fabacein	CFN91586	37710-13-7	C₃₄H₄₈O₉ = 600.7	5mg	QQ客服：1413575084
Arvenin II; Arvenin II	CFN92896	65247-28-1	C₃₈H₅₈O₁₃ = 722.86	5mg	QQ客服：1457312923
Arvenin III; Arvenin III	CFN95327	65597-45-7	C₃₆H₅₄O₁₂ = 678.8	5mg	QQ客服：1457312923
葫芦苦素D; Hexanorcucurbitacin D	CFN92893	29065-05-2	C₂₄H₃₄O₅ = 402.52	5mg	QQ客服：2056216494
葫芦素D; Cucurbitacin D	CFN90209	3877-86-9	C₃₀H₄₄O₇ = 516.67	10mg	QQ客服：1413575084
异葫芦素 D; Isocucurbitacin D	CFN95326	68422-20-8	C₃₀H₄₄O₇ = 516.7	5mg	QQ客服：215959384
23,24-二氢异葫芦素 B; 23,24-dihydroisocucurbitacin B	CFN92894	68354-21-2	C₃₂H₄₈O₈ = 560.72	5mg	QQ客服：1457312923
异葫芦素 B; Isocucurbitacin B	CFN91003	17278-28-3	C₃₂H₄₆O₈ = 558.7	10mg	QQ客服：3257982914

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7771 mL	8.8853 mL	17.7705 mL	35.541 mL	44.4263 mL
5 mM	0.3554 mL	1.7771 mL	3.5541 mL	7.1082 mL	8.8853 mL
10 mM	0.1777 mL	0.8885 mL	1.7771 mL	3.5541 mL	4.4426 mL
50 mM	0.0355 mL	0.1777 mL	0.3554 mL	0.7108 mL	0.8885 mL
100 mM	0.0178 mL	0.0889 mL	0.1777 mL	0.3554 mL	0.4443 mL

葫芦素 IIa； 雪胆素甲

Cucurbitacin IIA

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葫芦素 IIa；雪胆素甲