Cryptomoscatone D2

	产品编号	CFN96897
	CAS编号	276856-55-4
	分子式 = 分子量	C₁₇H₂₀O₄ = 288.34
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Phenols
	植物来源	The branches and stem barks of Cryptocarya moschata
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
Cryptomoscatone D2	CFN96897	276856-55-4	1mg	QQ客服：3004468088
Cryptomoscatone D2	CFN96897	276856-55-4	5mg	QQ客服：3004468088
Cryptomoscatone D2	CFN96897	276856-55-4	10mg	QQ客服：3004468088
Cryptomoscatone D2	CFN96897	276856-55-4	20mg	QQ客服：3004468088

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Brasilia (Brazil)

Biotech R&D Institute (USA)

Sanford Burnham Medical Research Institute (USA)

Rio de Janeiro State University (Brazil)

University of Mysore (India)

Charles University in Prague (Czech Republic)

Universiti Malaysia Pahang (Malaysia)

Colorado State University (USA)

Chang Gung University (Taiwan)

Sri Ramachandra University (India)

FORTH-IMBB (Greece)

Siksha O Anusandhan University (India)

Osmania University (India)

University of East Anglia (United Kingdom)

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Description:

Cryptomoscatone D2 is a highly efficacious inhibitor of the G(2) checkpoint, and G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage to enter mitosis.

Targets:

p53

In vitro:

Cancer Chemother Pharmacol. 2008 Mar;61(3):407-13.

Abrogation of ionizing radiation-induced G2 checkpoint and inhibition of nuclear export by Cryptocarya pyrones.[Pubmed: 17440726]

METHODS AND RESULTS:
G(2) checkpoint inhibitors can force cells arrested in G(2) phase by DNA damage to enter mitosis. In this manner, several G(2) checkpoint inhibitors can enhance killing of cancer cells by ionizing radiation and DNA-damaging chemotherapeutic agents, particularly in cells lacking p53 function. All G(2) checkpoint inhibitors identified to date target protein phosphorylation by inhibiting checkpoint kinases or phosphatases. Using a phenotypic cell-based assay for G(2) checkpoint inhibitors, we have screened a large collection of plant extracts and identified Z-Cryptofolione and Cryptomoscatone D2 as highly efficacious inhibitors of the G(2) checkpoint. These compounds and related pyrones also inhibit nuclear export. Leptomycin B, a potent inhibitor of Crm1-mediated nuclear export, is also a very potent G(2) checkpoint inhibitor.
CONCLUSIONS:
These compounds possess a reactive Michael acceptor site and do not appear promising as a radiosensitizing agents because they are toxic to unirradiated cells at checkpoint inhibitory concentrations. Nevertheless, the results show that inhibition of nuclear export is an alternative to checkpoint kinase inhibition for abrogating the G(2) checkpoint and they should stimulate the search for less toxic nuclear export inhibitors.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
新原莪述烯醇; Neoprocurcumenol	CFN92789	102130-91-6	C₁₅H₂₂O₂ = 234.3	5mg	QQ客服：3004468520
木蝴蝶苷A; Oroxin A	CFN99712	57396-78-8	C₂₁H₂₀O₁₀ = 432.38	20mg	QQ客服：3004468088
5-羟基黄酮; 5-Hydroxyflavone	CFN70123	491-78-1	C₁₅H₁₀O₃ = 238.2	20mg	QQ客服：3004468087
黄夹苦苷; Theviridoside	CFN98241	23407-76-3	C₁₇H₂₄O₁₁ = 404.4	5mg	QQ客服：3004468088

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4681 mL	17.3406 mL	34.6813 mL	69.3626 mL	86.7032 mL
5 mM	0.6936 mL	3.4681 mL	6.9363 mL	13.8725 mL	17.3406 mL
10 mM	0.3468 mL	1.7341 mL	3.4681 mL	6.9363 mL	8.6703 mL
50 mM	0.0694 mL	0.3468 mL	0.6936 mL	1.3873 mL	1.7341 mL
100 mM	0.0347 mL	0.1734 mL	0.3468 mL	0.6936 mL	0.867 mL