柯诺辛, 钩藤碱
Corynoxine
|
|
产品编号 |
CFN90218 |
| CAS编号 |
6877-32-3 |
| 分子式 = 分子量 |
C22H28N2O4 = 384.47 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Alkaloids |
| 植物来源 |
The vines of Uncaria rhynchopylla. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 柯诺辛, 钩藤碱 |
CFN90218 |
6877-32-3 |
10mg |
QQ客服：2056216494 |
| 柯诺辛, 钩藤碱 |
CFN90218 |
6877-32-3 |
20mg |
QQ客服：2056216494 |
| 柯诺辛, 钩藤碱 |
CFN90218 |
6877-32-3 |
50mg |
QQ客服：2056216494 |
| 柯诺辛, 钩藤碱 |
CFN90218 |
6877-32-3 |
100mg |
QQ客服：2056216494 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
University of Mysore (India)
Instytut Nawozów Sztucznych w Pu?awach (Poland)
University of Fribourg (Switzerland)
Charles University in Prague (Czech Republic)
Seoul National University (Korea)
Monash University Sunway Campus (Malaysia)
University of British Columbia (Canada)
Massachusetts General Hospital (USA)
Centralised Purchases Unit (CPU), B.I.T.S (India)
Martin Luther University of Halle-Wittenberg (Germany)
Monash University Malaysia (Malaysia)
University of Wollongong (Australia)
University of Hertfordshire (United Kingdom)
Deutsches Krebsforschungszentrum (Germany)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Corynoxine is a natural autophagy enhancer, promotes the clearance of Alpha-synuclein via Akt/mTOR pathway, it can significantly inhibit the oxidative stress of PC12 cells. |
| Targets: |
Akt | mTOR | Autophagy |
| In vitro: |
| Internal Medicine of China,2013,8(6):586-7. | | Study on application of statistical modeling on chromatogram-effect relation in Traditional Chinese Medicine[Reference: WebLink] | To establish chromatogram-effect model based on inhibitory effect of four alkaloids( rhynchophyline,isorhynchophylline,Corynoxine,Corynoxine B) on oxidative stress of glutamate-induced PC12 cells.
METHODS AND RESULTS:
Based on the chromatogram-effect relation of inhibitory effect of four alkaloids on the oxidative stress of glutamate-induced PC12 cells,SPSS 15. 0 was used to analyse data. Oxidative stress of PC12 cells was significantly inhibited by rhynchophyline and Corynoxine. The spectrum efficient equation was,Y = 44. 301 + 0. 255X 1 + 0. 356X 3( P 0. 05). The deviation of predictive value and true value was no more than 10% by data validation from seven samples.
CONCLUSIONS:
The chromatogram-effect model can be used to predict the effect of uncaria macrophylla wall against the oxidative stress of glutamate-induced PC12 cells. |
|
| In vivo: |
| Phytomedicine. 1999 Jul;6(3):163-8. | | Effect on locomotion of indole alkaloids from the hooks of uncaria plants.[Pubmed: 10439480] |
METHODS AND RESULTS:
Three predominant Uncariae plants, Uncaria rhynchophylla U. sinensis and U. macrophylla and their indole and oxindole alkaloid constituents were studied for their effect on locomotor response. Water extracts of U. macrophylla and U. sinensis and four indole alkaloids, corynoxine, corynoxine B, isorhynchophylline and geissoschizine methyl ether, significantly decreased locomotor activity after oral administration to mice.
CONCLUSIONS:
The depression of locomotor activity upon administration of these alkaloids appears to be due to mediating of the central dopaminergic system. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.601 mL |
13.0049 mL |
26.0098 mL |
52.0197 mL |
65.0246 mL |
| 5 mM |
0.5202 mL |
2.601 mL |
5.202 mL |
10.4039 mL |
13.0049 mL |
| 10 mM |
0.2601 mL |
1.3005 mL |
2.601 mL |
5.202 mL |
6.5025 mL |
| 50 mM |
0.052 mL |
0.2601 mL |
0.5202 mL |
1.0404 mL |
1.3005 mL |
| 100 mM |
0.026 mL |
0.13 mL |
0.2601 mL |
0.5202 mL |
0.6502 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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