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  • 湿地松酸

    Communic acid

    湿地松酸
    产品编号 CFN98332
    CAS编号 2761-77-5
    分子式 = 分子量 C20H30O2 = 302.5
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The branches of Platycladus orientalis
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    湿地松酸 CFN98332 2761-77-5 1mg QQ客服:2056216494
    湿地松酸 CFN98332 2761-77-5 5mg QQ客服:2056216494
    湿地松酸 CFN98332 2761-77-5 10mg QQ客服:2056216494
    湿地松酸 CFN98332 2761-77-5 20mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Uniwersytet Medyczny w ?odzi (Poland)
  • Biotech R&D Institute (USA)
  • Seoul National University (Korea)
  • University of Canterbury (New Zealand)
  • Centrum Menselijke Erfelijkheid (Belgium)
  • National Cancer Center Research Institute (Japan)
  • Universidade Católica Portuguesa (Portugal)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Georgia Institute of Technology (USA)
  • Heidelberg University (Germany)
  • University of Brasilia (Brazil)
  • University of Fribourg (Switzerland)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Medical University of Gdansk (Poland)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Res Int.2020, 128:108778
  • Molecules.2018, 23(10):E2638
  • Food Research International2016, 106-113
  • Int J Mol Sci.2020, 21(9):3144.
  • Curr Issues Mol Biol.2023, ;45(2):1601-1612.
  • Food Sci Biotechnol.2023, 32(9):1215-1223.
  • Industrial Food Engineering2015, 19(4):408-413
  • American Association for Anatomy2020, doi: 10.1002.
  • J of Advanced Scientific R.2020, 11(3), p109-120.
  • Phytomedicine.2022, 102:154183.
  • J.Food Processing & Preservation2022, jfpp.16666
  • Advances in Traditional Medicine 2021, 21:779-789.
  • Phytomedicine.2015, 22(11):1027-36
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Pharmaceutics2022, 14(2),376.
  • Phytomedicine.2021, 2(82):153452
  • Phytochemistry2018, 15:83-92
  • Molecules.2022, 27(21):7514.
  • Sci Rep.2019, 9:19059
  • Anticancer Res.2021, 41(3):1357-1364.
  • Eur Rev Med Pharmacol Sci.2020, 24(9):5127-5139.
  • Nutrients.2019, 11(6):E1380
  • Pharmaceuticals (Basel).2021, 14(3):260.
  • ...
  • 生物活性
    Description: Communic acid has antibacterial activity, including against mycobacterial. trans-Communic acid has potential to be utilized as anti-wrinkling agents and cosmetic ingredients, as they suppress UVB-induced MMP-1 expression.
    Targets: MMP(e.g.TIMP) | AP-1 | Akt | MAPK | PI3K | Antifection
    In vitro:
    PLoS One. 2015 Jun 11;10(6):e0128365.
    Brown Pine Leaf Extract and Its Active Component Trans-Communic Acid Inhibit UVB-Induced MMP-1 Expression by Targeting PI3K.[Pubmed: 26066652]

    METHODS AND RESULTS:
    HPLC analysis revealed that the quantity of trans-Communic acid (TCA) and dehydroabietic acid (DAA) significantly increases when the pine leaf color changes from green to brown. BPLE and trans-Communic acid elicited reductions in UVB-induced MMP-1 mRNA expression and activator protein-1 (AP-1) transactivation by reducing DNA binding activity of phospho-c-Jun, c-fos and Fra-1. BPLE and trans-Communic acid also inhibited UVB-induced Akt phosphorylation, but not mitogen activated protein kinase (MAPK), known regulators of AP-1 transactivation. We additionally found that BPLE and trans-Communic acid inhibited phosphoinositide 3-kinase (PI3K), the upstream kinase of Akt, in vitro. In summary, both BPLE and its active component trans-Communic acid exhibit protective effects against UVB-induced skin aging.
    CONCLUSIONS:
    Taken together, these findings underline the potential for BPLE and trans-Communic acid to be utilized as anti-wrinkling agents and cosmetic ingredients, as they suppress UVB-induced MMP-1 expression.
    J Ethnopharmacol. 2012 Sep 28;143(2):695-700.
    Anti-mycobacterial natural products from the Canadian medicinal plant Juniperus communis.[Pubmed: 22877928]
    Common juniper, Juniperus communis, is amongst the plants most frequently used by the indigenous peoples of North America for medicinal purposes. The First Nations of the Canadian Maritimes use infusions of juniper primarily as a tonic and for the treatment of tuberculosis. Previous investigations of extracts derived from the aerial parts of J. communis have shown it to possess anti-mycobacterial activity. The aim of the study is to isolate and identify anti-mycobacterial constituents from the aerial parts of J. communis.
    METHODS AND RESULTS:
    Methanolic extracts of J. communis needles and branches were subjected to bioassay guided fractionation using the microplate resazurin assay (MRA) to assess inhibitory activity against Mycobacterium tuberculosis strain H37Ra. The anti-mycobacterial constituents were identified by NMR, MS and polarimetry.The diterpenes isocupressic acid and communic acid and the aryltetralin lignan deoxypodophyllotoxin were isolated from the J. communis extract. Isocupressic acid and communic acid (isolated as an inseparable 3:2 mixture of cis and trans isomers) displayed MICs of 78 μM and 31 μM and IC(50)s of 46 μM and 15 μM against M. tuberculosis H37Ra respectively. Deoxypodophyllotoxin was less active, with a MIC of 1004 μM and an IC(50) of 287 μM.
    CONCLUSIONS:
    Isocupressic acid, communic acid and deoxypodophyllotoxin were identified as the principal constituents responsible for the anti-mycobacterial activity of the aerial parts of J. communis. Although further research will be required to evaluate the relative activities of the two communic acid isomers, this work validates an ethnopharmacological use of this plant by Canadian First Nations and Native American communities.
    Phytother Res. 2008 Dec;22(12):1570-6.
    Antiparasitic, nematicidal and antifouling constituents from Juniperus berries.[Pubmed: 19067375]

    METHODS AND RESULTS:
    A bioassay-guided fractionation of Juniperus procera berries yielded antiparasitic, nematicidal and antifouling constituents, including a wide range of known abietane, pimarane and labdane diterpenes. Among these, abieta-7,13-diene (1) demonstrated in vitro antimalarial activity against Plasmodium falciparum D6 and W2 strains (IC(50) = 1.9 and 2.0 microg/mL, respectively), while totarol (6), ferruginol (7) and 7beta-hydroxyabieta-8,13-diene-11,12-dione (8) inhibited Leishmania donovani promastigotes with IC(50) values of 3.5-4.6 microg/mL. In addition, totarol demonstrated nematicidal and antifouling activities against Caenorhabditis elegans and Artemia salina at a concentration of 80 microg/mL and 1 microg/mL, respectively. The resinous exudate of J. virginiana afforded known antibacterial E-Communic acid (4) and 4-epi-abietic acid (5), while the volatile oil from its trunk wood revealed large quantities of cedrol (9).
    CONCLUSIONS:
    Using GC/MS, the two known abietanes totarol (6) and ferruginol (7) were identified from the berries of J. procera, J. excelsa and J. phoenicea.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3058 mL 16.5289 mL 33.0579 mL 66.1157 mL 82.6446 mL
    5 mM 0.6612 mL 3.3058 mL 6.6116 mL 13.2231 mL 16.5289 mL
    10 mM 0.3306 mL 1.6529 mL 3.3058 mL 6.6116 mL 8.2645 mL
    50 mM 0.0661 mL 0.3306 mL 0.6612 mL 1.3223 mL 1.6529 mL
    100 mM 0.0331 mL 0.1653 mL 0.3306 mL 0.6612 mL 0.8264 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    香紫苏醇; Sclareol CFN90249 515-03-7 C20H36O2 = 308.50 20mg QQ客服:2056216494
    13-表泪杉醇; 13-表迈诺醇; 13-Epimanool CFN97997 1438-62-6 C20H34O = 290.5 5mg QQ客服:215959384
    6alpha-羟基尼刀瑞尔醇; 6alpha-Hydroxynidorellol CFN97701 70387-38-1 C20H34O3 = 322.49 5mg QQ客服:2159513211
    反式-可母尼醇,湿地松醇; Elliotinol CFN99033 10178-31-1 C20H32O = 288.5 5mg QQ客服:2056216494
    8alpha-羟基赖百当-13(16),14-二烯-19-基对羟基肉桂酸酯; 8alpha-Hydroxylabda-13(16),14-dien-19-yl p-hydroxycinnamate CFN97847 117254-98-5 C29H40O4 = 452.63 5mg QQ客服:2056216494
    8(17),12E,14-Labdatrien-20-oic acid; 8(17),12E,14-Labdatrien-20-oic acid CFN89102 1639257-36-5 C20H30O2 = 302.45 5mg QQ客服:1413575084
    12E,14-Labdadien-20,8beta-olide; 12E,14-Labdadien-20,8beta-olide CFN89101 1639257-37-6 C20H30O2 = 302.45 5mg QQ客服:2056216494
    13-羟基赖百当-8(17),14-二烯-18-酸; 13-Hydroxylabda-8(17),14-dien-18-oic acid CFN97332 83915-59-7 C20H32O3 = 320.5 5mg QQ客服:2159513211
    4-表可木酸; 4-Epicommunic acid CFN97334 83945-57-7 C20H30O2 = 302.5 5mg QQ客服:1413575084
    湿地松酸; Communic acid CFN98332 2761-77-5 C20H30O2 = 302.5 5mg QQ客服:2159513211

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