类蛇麻酮

Colupulone

	产品编号	CFN91873
	CAS编号	468-27-9
	分子式 = 分子量	C₂₅H₃₆O₄ = 400.55
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	The herbs of Humulus lupulus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
类蛇麻酮	CFN91873	468-27-9	1mg	QQ客服：2159513211
类蛇麻酮	CFN91873	468-27-9	5mg	QQ客服：2159513211
类蛇麻酮	CFN91873	468-27-9	10mg	QQ客服：2159513211
类蛇麻酮	CFN91873	468-27-9	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

National Cancer Center Research Institute (Japan)

Universidad Veracuzana (Mexico)

Lodz University of Technology (Poland)

Centralised Purchases Unit (CPU), B.I.T.S (India)

Universidad de La Salle (Mexico)

Universiti Sains Malaysia (Malaysia)

Universidade de Franca (Brazil)

University of Padjajaran (Indonesia)

University of Helsinki (Finland)

University of the Basque Country (Spain)

Wroclaw Medical University (Poland)

FORTH-IMBB (Greece)

University of Queensland (Australia)

Celltrion Chemical Research Institute (Korea)

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Description:

Colupulone is an inducer of hepatic cytochrome P-4503A .Colupulone can increase cytochrome P450IIB and P450IIIA steady-state mRNA levels. Colupulone also has antibacterial effects.

Targets:

P450 (e.g. CYP17) | Calcium Channel | Sodium Channel | Potassium Channel | Antifection

In vitro:

J Appl Bacteriol. 1992 Apr;72(4):327-34.

Factors affecting antibacterial activity of hop compounds and their derivatives.[Pubmed: 1517174]

The antibacterial effect of weak acids derived from the hop plant (Humulus lupulus L.) increased with decreasing pH.
METHODS AND RESULTS:
Analysis of the minimum inhibitory concentration of such compounds against Lactobacillus brevis IFO 3960 over pH 4-7 suggests that undissociated molecules were mainly responsible for inhibition of bacterial growth. The antibacterial activity of trans-isohumulone was ca 20 times greater than that of humulone, 11 times greater than that of Colupulone and nine times greater than that of trans-humulinic acid when the degree of ionization was taken into account. Monovalent cations (K+, Na+, NH4+, Rb+, Li+) stimulated antibacterial activity of trans-isohumulone but the effect was smaller than that observed with H+. The response to divalent cations varied: Ca2+ had little effect on antibacterial activity, whereas Mg2+ reduced activity. Lipid materials and beta-cyclodextrin also antagonized the antibacterial action of trans-isohumulone.

In vivo:

Food Chem Toxicol. 1994 Nov;32(11):1007-14.

The effect of colupulone (a HOPS beta-acid) on hepatic cytochrome P-450 enzymatic activity in the rat.[Pubmed: 7959454]

Colupulone, a component of hops, was examined for its ability to alter rat hepatic cytochrome P-450 enzymatic activity, expression of hepatic cytochrome P-450 mRNA, and in vitro promutagen activation.
METHODS AND RESULTS:
Colupulone was fed to male Sprague-Dawley rats for 5 days at 0.36% in the modified AIN 76 diet. Three cytochrome P-450 enzymatic activities were measured, and the corresponding steady-state mRNA levels were examined by Northern blot hybridization. Colupulone increased cytochrome P450IIB and P450IIIA steady-state mRNA levels. In vitro promutagen activation was measured in the Ames assay using liver homogenates from each treatment group. Colupulone treatment did not alter the ex vivo cytochrome P-450-mediated activation of aflatoxin B1 or benzo[a]pyrene to their mutagenic forms.
CONCLUSIONS:
The effect of long-term Colupulone administration on in vivo cytochrome P-450 enzymatic activity remains to be determined.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
啤酒花酸; Hulupinic acid	CFN91955	1891-42-5	C₁₅H₂₀O₄ = 264.32	5mg	QQ客服：1457312923
律草酮; Humulone	CFN90541	26472-41-3	C₂₁H₃₀O₅ = 362.45	5mg	QQ客服：3257982914
类蛇麻酮; Colupulone	CFN91873	468-27-9	C₂₅H₃₆O₄ = 400.55	5mg	QQ客服：2159513211
8-Hydroxyhyperforin 8,1-hemiacetal; 8-Hydroxyhyperforin 8,1-hemiacetal	CFN97001	59014-02-7	C₃₅H₅₂O₅ = 552.8	5mg	QQ客服：3257982914
Perforatumone; Perforatumone	CFN97317	827319-50-6	C₃₅H₅₂O₅ = 552.8	5mg	QQ客服：2159513211

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4966 mL	12.4828 mL	24.9657 mL	49.9313 mL	62.4142 mL
5 mM	0.4993 mL	2.4966 mL	4.9931 mL	9.9863 mL	12.4828 mL
10 mM	0.2497 mL	1.2483 mL	2.4966 mL	4.9931 mL	6.2414 mL
50 mM	0.0499 mL	0.2497 mL	0.4993 mL	0.9986 mL	1.2483 mL
100 mM	0.025 mL	0.1248 mL	0.2497 mL	0.4993 mL	0.6241 mL