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  • 类蛇麻酮

    • 类蛇麻酮

    Colupulone

    类蛇麻酮
    		产品编号 CFN91873
    CAS编号 468-27-9
    分子式 = 分子量 C25H36O4 = 400.55
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Miscellaneous
    植物来源 The herbs of Humulus lupulus
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    类蛇麻酮 CFN91873 468-27-9 1mg QQ客服：1457312923
    类蛇麻酮 CFN91873 468-27-9 5mg QQ客服：1457312923
    类蛇麻酮 CFN91873 468-27-9 10mg QQ客服：1457312923
    类蛇麻酮 CFN91873 468-27-9 20mg QQ客服：1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Parma (Italy)
  • Nanjing University of Chinese Medicine (China)
  • Monash University Sunway Campus (Malaysia)
  • University of Helsinki (Finland)
  • National Cancer Center Research Institute (Japan)
  • Lodz University of Technology (Poland)
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  • Kyoto University (Japan)
  • Donald Danforth Plant Science Center (USA)
  • Universiti Malaysia Pahang (Malaysia)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Funct.2022, doi: 10.1039
  • Metabolites.2019, 9(11):E271
  • Chem Biol Interact.2024, 395:110999.
  • Food Funct.2020, 11(2):1322-1333.
  • Pharmaceutics.2022, 14(5):945.
  • Phytochem Anal.2016, 27(5):296-303
  • Horticulturae2023, 9(2), 213.
  • Earth Environ. Sci. 2021, 905:012080.
  • PLoS One.2020, 15(2):e0220084.
  • Molecules.2019, 25(1):E103
  • Molecules.2023, 28(13):4907.
  • J Drug Target.2016, 24:1-28
  • Evid Based Complement Alternat Med.2021, 2021:5585692.
  • J Immunol.2023, ji2200727.
  • Molecules2022, 27(9):2613.
  • Functional Ecology2020, doi: 10.1111.
  • Int J Pharm.2022, 618:121636.
  • J Separation Science & Technology2016, 51:1579-1588
  • Babol University of Medical Sciences2024, rs-4289336
  • J Food Sci Technol.2022, 59(1):212-219.
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • Food Res Int.2020, 128:108778
  • VNU Journal of Science2023, No. 20.
  • ...
    • 生物活性
    Description: Colupulone is an inducer of hepatic cytochrome P-4503A .Colupulone can increase cytochrome P450IIB and P450IIIA steady-state mRNA levels. Colupulone also has antibacterial effects.
    Targets: P450 (e.g. CYP17) | Calcium Channel | Sodium Channel | Potassium Channel | Antifection
    In vitro:
    J Appl Bacteriol. 1992 Apr;72(4):327-34.
    Factors affecting antibacterial activity of hop compounds and their derivatives.[Pubmed: 1517174]
    The antibacterial effect of weak acids derived from the hop plant (Humulus lupulus L.) increased with decreasing pH.
    METHODS AND RESULTS:
    Analysis of the minimum inhibitory concentration of such compounds against Lactobacillus brevis IFO 3960 over pH 4-7 suggests that undissociated molecules were mainly responsible for inhibition of bacterial growth. The antibacterial activity of trans-isohumulone was ca 20 times greater than that of humulone, 11 times greater than that of Colupulone and nine times greater than that of trans-humulinic acid when the degree of ionization was taken into account. Monovalent cations (K+, Na+, NH4+, Rb+, Li+) stimulated antibacterial activity of trans-isohumulone but the effect was smaller than that observed with H+. The response to divalent cations varied: Ca2+ had little effect on antibacterial activity, whereas Mg2+ reduced activity. Lipid materials and beta-cyclodextrin also antagonized the antibacterial action of trans-isohumulone.
    In vivo:
    Food Chem Toxicol. 1994 Nov;32(11):1007-14.
    The effect of colupulone (a HOPS beta-acid) on hepatic cytochrome P-450 enzymatic activity in the rat.[Pubmed: 7959454]
    Colupulone, a component of hops, was examined for its ability to alter rat hepatic cytochrome P-450 enzymatic activity, expression of hepatic cytochrome P-450 mRNA, and in vitro promutagen activation.
    METHODS AND RESULTS:
    Colupulone was fed to male Sprague-Dawley rats for 5 days at 0.36% in the modified AIN 76 diet. Three cytochrome P-450 enzymatic activities were measured, and the corresponding steady-state mRNA levels were examined by Northern blot hybridization. Colupulone increased cytochrome P450IIB and P450IIIA steady-state mRNA levels. In vitro promutagen activation was measured in the Ames assay using liver homogenates from each treatment group. Colupulone treatment did not alter the ex vivo cytochrome P-450-mediated activation of aflatoxin B1 or benzo[a]pyrene to their mutagenic forms.
    CONCLUSIONS:
    The effect of long-term Colupulone administration on in vivo cytochrome P-450 enzymatic activity remains to be determined.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4966 mL 12.4828 mL 24.9657 mL 49.9313 mL 62.4142 mL
    5 mM 0.4993 mL 2.4966 mL 4.9931 mL 9.9863 mL 12.4828 mL
    10 mM 0.2497 mL 1.2483 mL 2.4966 mL 4.9931 mL 6.2414 mL
    50 mM 0.0499 mL 0.2497 mL 0.4993 mL 0.9986 mL 1.2483 mL
    100 mM 0.025 mL 0.1248 mL 0.2497 mL 0.4993 mL 0.6241 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    啤酒花酸; Hulupinic acid CFN91955 1891-42-5 C15H20O4 = 264.32 5mg QQ客服：1457312923
    律草酮; Humulone CFN90541 26472-41-3 C21H30O5 = 362.45 5mg QQ客服：2056216494
    类蛇麻酮; Colupulone CFN91873 468-27-9 C25H36O4 = 400.55 5mg QQ客服：2056216494
    8-Hydroxyhyperforin 8,1-hemiacetal; 8-Hydroxyhyperforin 8,1-hemiacetal CFN97001 59014-02-7 C35H52O5 = 552.8 5mg QQ客服：215959384
    Perforatumone; Perforatumone CFN97317 827319-50-6 C35H52O5 = 552.8 5mg QQ客服：1457312923

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