衡州乌药碱；乌药碱

Coclaurine

	产品编号	CFN98769
	CAS编号	486-39-5
	分子式 = 分子量	C₁₇H₁₉NO₃ = 285.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The roots of Coptis chinensis Franch
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
衡州乌药碱；乌药碱	CFN98769	486-39-5	1mg	QQ客服：215959384
衡州乌药碱；乌药碱	CFN98769	486-39-5	5mg	QQ客服：215959384
衡州乌药碱；乌药碱	CFN98769	486-39-5	10mg	QQ客服：215959384
衡州乌药碱；乌药碱	CFN98769	486-39-5	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Universidade da Beira Interior (Germany)

University of Bonn (Germany)

University of Minnesota (USA)

Instituto Politécnico de Bragan?a (Portugal)

Monash University Sunway Campus (Malaysia)

Nanjing University of Chinese Medicine (China)

Centralised Purchases Unit (CPU), B.I.T.S (India)

Uniwersytet Jagielloński w Krakowie (Poland)

University of Maryland School of Medicine (USA)

Institute of Tropical Disease Universitas Airlangga (Indonesia)

Gyeongsang National University (Korea)

The Ohio State University (USA)

Utah State University (USA)

National Chung Hsing University (Taiwan)

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Description:

(+)-R-Coclaurine and (+)-S-reticuline show negative inotropic effects, coclaurine derivatives and of paeoniflorin derivatives have neuromuscular blocking actions. D-Coclaurine has a neuroleptic-like property in blocking effects of dopaminergic stimulating agents.

Targets:

Calcium Channel

In vitro:

Jpn J Pharmacol. 1989 May;50(1):75-8.

Inotropic effects of (+/-)-higenamine and its chemically related components, (+)-R-coclaurine and (+)-S-reticuline, contained in the traditional sino-Japanese medicines [Pubmed: 2724702]

(+/-)-Higenamine (Hig. demethylCoclaurine) is a cardiotonic principle from aconite root. (+)-R-Coclaurine (Coc) and (+)-S-reticuline (Ret) are compounds contained in the dried buds of Magnolia salicifolia MAXIM.
METHODS AND RESULTS:
All of these alkaloids possess a common chemical structure: tetrahydroisoquinoline. Coc and Ret showed negative inotropic effects in contrast to the positive inotropic effects of Hig in papillary muscles of guinea pigs. Coc and Ret shifted to the right the concentration-contraction curves of Hig. Hig shifted in parallel to the left the Ca2+ curve, and it tended to shift to the left the isoproterenol (Isp)-induced response curve. In contrast, Coc and Ret inhibited the Ca2+ curve and the low concentration range of the Isp-induced curve, and it potentiated the high concentration ranges of Ca2+ and Isp.
CONCLUSIONS:
Coc and Ret showed actions that were reversed in direction to those of Hig, as clearly demonstrated in the Ca2+ curve.

Planta Med. 1982 Jul;45(3):136.

The neuromuscular blocking actions of coclaurine derivatives and of paeoniflorin derivatives.[Pubmed: 17396817 ]

METHODS AND RESULTS:
The neuromuscular blocking actions of coclaurine derivatives and of paeoniflorin derivatives.

In vivo:

J Pharmacobiodyn. 1983 Oct;6(10):793-6.

Effects of d-coclaurine and d-reticuline, benzyltetrahydroisoquinoline alkaloids, on levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid in the mouse striatum.[Pubmed: 6141236]

METHODS AND RESULTS:
An intracerebroventricular injection of d-Coclaurine (50 micrograms), a benzyltetrahydroisoquinoline alkaloid extracted from Magnolia salicifolia, produced a slight increase in 3,4-dihydroxyphenylacetic acid level and a significant increase in homovanillic acid level in the mouse striatum. Another alkaloid d-reticuline (200 micrograms) increased only homovanillic acid level. An intracerebroventricular pretreatment with d-Coclaurine (50 micrograms) did not antagonize suppressive effect of apomorphine on l-dopa formation produced by gamma-butyrolactone (750 mg/kg i.p.) plus aromatic amino acid decarboxylase inhibitor, NSD-1015 (100 mg/kg i.p.).
CONCLUSIONS:
These results suggest that d-Coclaurine blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
N-甲基乌药碱; N-Methylcoclaurine	CFN96775	5096-70-8	C₁₈H₂₁NO₃ = 299.37	5mg	QQ客服：3257982914
N-甲基去氢乌药碱; N-Methyldehydrococlaurine	CFN95588	N/A	C₁₈H₂₀NO₃+ = 298.4	5mg	QQ客服：2159513211
四氢罂粟碱盐酸盐; Tetrahydropapaverine hydrochloride	CFN96626	6429-04-5	C₂₀H₂₆ClNO₄ = 379.88	5mg	QQ客服：3257982914
木兰箭毒碱; Magnocurarine	CFN93230	6801-40-7	C₁₉H₂₄NO₃ = 314.4	20mg	QQ客服：1457312923
Norjuziphine; Norjuziphine	CFN92409	74119-87-2	C₁₇H₁₉NO₃ = 285.3	5mg	QQ客服：3257982914
Oblongine; Oblongine	CFN97013	60008-01-7	C₁₉H₂₄NO₃ = 314.4	10mg	QQ客服：215959384
N-Demethylfordianoside; N-Demethylfordianoside	CFN95589	N/A	C₂₃H₃₀NO₈+ = 448.5	10mg	QQ客服：1457312923
牛心果碱; Reticuline	CFN98767	485-19-8	C₁₉H₂₃NO₄ = 329.4	5mg	QQ客服：215959384
(R)-牛心果碱; (R)-Reticuline	CFN95013	3968-19-2	C₁₉H₂₃NO₄ = 329.4	5mg	QQ客服：1413575084
藤泊它碱; Tembetarine	CFN95542	18446-73-6	C₂₀H₂₆NO₄ = 344.4	5mg	QQ客服：3257982914

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5051 mL	17.5254 mL	35.0508 mL	70.1016 mL	87.6271 mL
5 mM	0.701 mL	3.5051 mL	7.0102 mL	14.0203 mL	17.5254 mL
10 mM	0.3505 mL	1.7525 mL	3.5051 mL	7.0102 mL	8.7627 mL
50 mM	0.0701 mL	0.3505 mL	0.701 mL	1.402 mL	1.7525 mL
100 mM	0.0351 mL	0.1753 mL	0.3505 mL	0.701 mL	0.8763 mL

衡州乌药碱；乌药碱

Coclaurine

信息支持

联系方式

衡州乌药碱； 乌药碱

Coclaurine

信息支持

联系方式

衡州乌药碱；乌药碱