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  • 肉桂酸

    Cinnamic acid

    肉桂酸
    产品编号 CFN99453
    CAS编号 140-10-3
    分子式 = 分子量 C9H8O2 = 148.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Phenylpropanoids
    植物来源 The barks of Cinnamomum cassia.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    产品名称 产品编号 CAS编号 包装 QQ客服
    肉桂酸 CFN99453 140-10-3 10mg QQ客服:2159513211
    肉桂酸 CFN99453 140-10-3 20mg QQ客服:2159513211
    肉桂酸 CFN99453 140-10-3 50mg QQ客服:2159513211
    肉桂酸 CFN99453 140-10-3 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Tohoku University (Japan)
  • University of Bordeaux (France)
  • University of Cincinnati (USA)
  • Technical University of Denmark (Denmark)
  • Copenhagen University (Denmark)
  • Medical University of South Carolina (USA)
  • Sanford Burnham Prebys Medical Discovery Institute (USA)
  • Universidade Católica Portuguesa (Portugal)
  • University of Bonn (Germany)
  • University of Pretoria (South Africa)
  • Universite de Lille1 (France)
  • University of Brasilia (Brazil)
  • Ain Shams University (Egypt)
  • Chang Gung University (Taiwan)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cells.2021, 10(11):2919.
  • Clin Exp Pharmacol Physiol.2015, 42(11):1189-97
  • Chinese Journal of Hospital Pharmacy2020, 40(7)
  • Cancers (Basel).2021, 13(17):4327.
  • Phytochem Anal.2023, pca.3305.
  • BMC Complement Altern Med.2019, 19(1):367
  • Plants (Basel).2023, 12(22):3877.
  • Nat Commun.2021, 12(1):681.
  • Biochem Biophys Res Commun.2018, 505(1):261-266
  • Molecules.2021, 26(23):7390.
  • Food Analytical Methods2020, 13,1603-1612(2020)
  • Phytomedicine.2015, 22(14):1262-8
  • Food Chem.2019, 290:286-294
  • Russian J Bioorganic Chemistry 2021, 47:1411-1417.
  • Nutrients.2019, 12(1):E40
  • Life Sci.2022, 311(Pt A):121157.
  • Food Chem.2016, 191:81-90
  • Toxicol Res.2019, 35(4):371-387
  • Sci Rep. 2017, 8207(7)
  • Cancers (Basel).2021, 13(9):2223.
  • Food Research2021, 5(1):65-71
  • Foods.2022, 11(12):1708.
  • Anal Bioanal Chem.2023, 415(9):1641-1655.
  • ...
  • 生物活性
    Description: Cinnamic acid, a naturally occurring aromatic fatty acid of low toxicity, has anti-diabetic , anticancer and antioxidant activities. It is a cell differentiation inducer and protein isoprenylation inhibitor, shows a significant radio-protective effect by reducing the DNA damage induced by X-rays. Cinnamic acid inhibited feeding by detritivores, this inhibition occurs at concentrations found in nature and may be a major factor controlling the rate of decay of organic matter. It inhibited mushroom tyrosinase activity in reversiblywith the IC 50 value of 2.10 mM.
    Targets: p53 | c-myc | c-fos | Tyrosinase
    In vitro:
    Mutat Res Genet Toxicol Environ Mutagen. 2014 Aug;770:72-9.
    Radio-protective effect of cinnamic acid, a phenolic phytochemical, on genomic instability induced by X-rays in human blood lymphocytes in vitro.[Pubmed: 25344167]

    METHODS AND RESULTS:
    The present study was designed to determine the protective activity of cinnamic acid against induction by X-rays of genomic instability in normal human blood lymphocytes. This radio-protective activity was assessed by use of the cytokinesis-block micronucleus test and the alkaline comet assay, with human blood lymphocytes isolated from two healthy donors. A Siemens Mevatron MD2 (Siemens AG, USA, 1994) linear accelerator was used for the irradiation with 1 or 2 Gy. Treatment of the lymphocytes with cinnamic acid prior to irradiation reduced the number of micronuclei when compared with that in control samples. Treatment with cinnamic acid without irradiation did not increase the number of micronuclei and did not show a cytostatic effect in the lymphocytes. The results of the alkaline comet assay revealed that cinnamic acid reduces the DNA damage induced by X-rays, showing a significant radio-protective effect. Cinnamic acid decreased the frequency of irradiation-induced micronuclei by 16-55% and reduced DNA breakage by 17-50%, as determined by the alkaline comet assay.
    CONCLUSIONS:
    Cinnamic acid may thus act as a radio-protective compound, and future studies may focus on elucidating the mechanism by which cinnamic acid offers radioprotection.
    Plant & Soil, 2004, 263(1):143-50.
    Incidence of Fusarium wilt in Cucumis sativus L. is promoted by cinnamic acid, an autotoxin in root exudates[Reference: WebLink]

    METHODS AND RESULTS:
    The effects of Fusarium oxysporum f. sp. cucumerinum, the pathogen causing Fusarium wilt in cucumber and cinnamic acid, a principal autotoxic component in the root exudates of cucumber (Cucumis sativus L.), on plant growth, Photosynthesis and incidence of Fusarium wilt in cucumber were studied in order to elucidate the interaction of autotoxins and soil-borne pathogens in the soil sickness. F. oxysporum. f. sp. cucumerinum (FO) and cinnamic acid (CA) at 0.1 or 0.25 mM significantly decreased net photosynthetic rate, stomatal conductance and the quantum yield of Photosystem II photochemistry (ΦPSII), followed by a reduction of plant biomass production, but did not induce photoinhibition. Pretreatment with CA before inoculation with FO increased the effectiveness of FO, together with a slight photoinhibition. CA pretreatment significantly increased percentage of plants affected by Fusarium wilt, browning index of vascular bundle and Fusarium population in the nutrient solution.
    CONCLUSIONS:
    All these results indicate that CA enhanced Fusarium wilt by predisposing cucumber roots to infection by FO through a direct biochemical and physiological effect. It is likely that soil sickness results from an interaction of many factors.
    Nature, 1979, 280(280):55-7.
    Cinnamic acid inhibition of detritus feeding. [Reference: WebLink]
    AN important advance in ecology has been the general acceptance of Fraenkel's postulate that certain chemicals in plants deter herbivores1–3. Such chemicals are usually termed secondary plant substances because they are not involved in primary metabolic pathways. Very little of the annual production of biomass by higher plants is consumed by herbivores or phyto-pathogens4. Instead, most of the biomass becomes litter and eventually decays through the activity of decomposers. The secondary compounds that deter grazers while the plants are alive do not disappear immediately when plants senesce and die. We have therefore investigated whether these anti-herbivore substances continue to inhibit consumption by organisms feeding on litter or detritus. We report here that cinnamic acids, one type of secondary plant substances found in detritus, inhibit feeding by detritivores. This inhibition occurs at concentrations found in nature and may be a major factor controlling the rate of decay of organic matter.
    2018 Sep 4.
    Antimicrobial activity of trans-cinnamic acid and commonly used antibiotics against important fish pathogens and nonpathogenic isolates[Pubmed: 30179290]
    Aims: Antibiotics and several other chemicals have been used to prevent fish diseases. However, this situation results in economic loss for the companies in the aquaculture industry and most importantly it pollutes the environment. Cinnamic acid is a naturally occurring aromatic acid and is considered to be safe for human consumption. Therefore, in this study, the antibacterial activity of trans-cinnamic acid and commonly used antibiotics, namely chloramphenicol, vancomycin, streptomycin and erythromycin, were tested against 32 bacteria, including fish pathogens, nonpathogenic isolates and collection strains. Methods and results: Trans-cinnamic acid was applied against the bacteria using the disc diffusion and microdilution method under in vitro conditions. Antibiotics were also tested under similar conditions against all tested bacteria using the disc diffusion method. The results show that among 32 bacterial strains trans-cinnamic acid exhibited potent inhibitory effect on the Gram-negative fish pathogen Aeromonas sobria. In addition, a moderate inhibition of trans-cinnamic acid of fish pathogens Aeromonas salmonicida, Vibrio (Listonella) anguillarum, Vibrio crassostreae and Yersinia ruckeri was also observed for trans-cinnamic acid in our study. On the contrary, the majority of nonpathogenic intestinal isolates were resistant to trans-cinnamic acid. Conclusions: To the best of our knowledge, this is the first report on the antimicrobial activity of trans-cinnamic acid on 24 of the studied bacteria isolated from fish. In conclusion, trans-cinnamic acid can be used as an environmentally friendly alternative additive to prevent and control primarily A. sobria, as well as other pathogenic bacteria such as A. salmonicida, V. anguillarum, V. crassostreae and Y. ruckeri. Significance and impact of the study: This study indicated that trans-cinnamic acid may present an environmentally friendly alternative therapeutic agent against A. sobria infections in the aquaculture industry. Keywords: antimicrobial; fish pathogens; intestine; phenolic organic acid; trans-cinnamic acid.
    In vivo:
    Phytomedicine. 2015 Feb 15;22(2):297-300.
    Cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and by stimulating insulin secretion in vitro.[Pubmed: 25765836]
    Although the anti-diabetic activity of cinnamic acid, a pure compound from cinnamon, has been reported but its mechanism(s) is not yet clear.
    METHODS AND RESULTS:
    The present study was designed to explore the possible mechanism(s) of anti-diabetic activity of cinnamic acid in in vitro and in vivo non-obese type 2 diabetic rats. Non-obese type 2 diabetes was developed by injecting 90 mg/kg streptozotocin in 2-day-old Wistar pups. Cinnamic acid and cinnamaldehyde were administered orally to diabetic rats for assessing acute blood glucose lowering effect and improvement of glucose tolerance. Additionally, insulin secretory activity of cinnamic acid and cinnamaldehyde was evaluated in isolated mice islets. Cinnamic acid, but not cinnamaldehyde, decreased blood glucose levels in diabetic rats in a time- and dose-dependent manner. Oral administration of cinnamic acid with 5 and 10 mg/kg doses to diabetic rats improved glucose tolerance in a dose-dependent manner. The improvement by 10 mg/kg cinnamic acid was comparable to that of standard drug glibenclamide (5 mg/kg). Further in vitro studies showed that cinnamaldehyde has little or no effect on glucose-stimulated insulin secretion; however, cinnamic acid significantly enhanced glucose-stimulated insulin secretion in isolated islets.
    CONCLUSIONS:
    In conclusion, it can be said that cinnamic acid exerts anti-diabetic activity by improving glucose tolerance in vivo and stimulating insulin secretion in vitro.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.7476 mL 33.7382 mL 67.4764 mL 134.9528 mL 168.691 mL
    5 mM 1.3495 mL 6.7476 mL 13.4953 mL 26.9906 mL 33.7382 mL
    10 mM 0.6748 mL 3.3738 mL 6.7476 mL 13.4953 mL 16.8691 mL
    50 mM 0.135 mL 0.6748 mL 1.3495 mL 2.6991 mL 3.3738 mL
    100 mM 0.0675 mL 0.3374 mL 0.6748 mL 1.3495 mL 1.6869 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    3-苯丙醇; Hydrocinnamyl alcohol CFN91549 122-97-4 C9H12O = 136.2 20mg QQ客服:2056216494
    3-苯丙酸; Hydrocinnamic acid CFN96158 501-52-0 C9H10O2 = 150.2 1g QQ客服:215959384
    肉桂酸; Cinnamic acid CFN99453 140-10-3 C9H8O2 = 148.2 20mg QQ客服:215959384
    肉桂酸甲酯; Methyl cinnamate CFN98198 103-26-4 C10H10O2 = 162.19 20mg QQ客服:1457312923
    肉桂酸乙酯; Ethyl cinnamate CFN98199 103-36-6 C11H12O2 = 176.21 20mg QQ客服:215959384
    肉桂酸乙烯酯; Vinyl Cinnamate CFN98195 3098-92-8 C11H10O2 = 174.2 20mg QQ客服:215959384
    肉桂酸苄酯; Benzyl cinnamate CFN98196 103-41-3 C16H14O2 = 238.28 20mg QQ客服:2056216494
    桂酸桂酯; Cinnamyl cinnamate CFN97841 122-69-0 C18H16O2 = 264.32 20mg QQ客服:1413575084
    反式-桂皮酸酐; trans-Cinnamic anhydride CFN92934 21947-71-7 C18H14O3 = 278.30 5mg QQ客服:2159513211

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