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  • 肉桂醛

    Cinnamaldehyde

    肉桂醛
    产品编号 CFN99478
    CAS编号 104-55-2
    分子式 = 分子量 C9H8O = 132.2
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Phenylpropanoids
    植物来源 The barks of Cinnamomum cassia
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    肉桂醛 CFN99478 104-55-2 10mg QQ客服:3257982914
    肉桂醛 CFN99478 104-55-2 20mg QQ客服:3257982914
    肉桂醛 CFN99478 104-55-2 50mg QQ客服:3257982914
    肉桂醛 CFN99478 104-55-2 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Max Rubner-Institut (MRI) (Germany)
  • Technical University of Denmark (Denmark)
  • Universidade de Franca (Brazil)
  • University of Cincinnati (USA)
  • Tohoku University (Japan)
  • Chang Gung University (Taiwan)
  • Sanford Burnham Medical Research Institute (USA)
  • National Hellenic Research Foundation (Greece)
  • Biotech R&D Institute (USA)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • University of British Columbia (Canada)
  • Pennsylvania State University (USA)
  • University of Madras (India)
  • University of Vienna (Austria)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2016, 21(10)
  • Int J Biol Macromol.2021, 199:189-200.
  • Nutrients.2018, 10(12):E1998
  • Korean Herb. Med. Inf.2020, 8(2):233-242.
  • Life Sci.2021, 270:119074.
  • Plants (Basel).2021, 10(7):1376.
  • Phytomedicine.2018, 47:48-57
  • Metabolites2023, 13(1), 3.
  • Evid Based Complement Alternat Med.2022, 2022:3483511
  • Plants (Basel).2021, 10(12):2795.
  • Universitat Stuttgart2022, opus-12200.
  • Asian J Beauty Cosmetol2020, 18(3): 265-272.
  • J Pharmacol Sci.2021, 147(2):184-191.
  • J. Soc. Cosmet. Sci. Korea2021, 47(1):57-63
  • Korean J of Medicinal Crop Science2018, 220-226
  • AMB Express2020. 10(1):126.
  • Chemistry of Plant Raw Materials2019, 4:135-147
  • Front Pharmacol.2017, 8:673
  • Molecules.2020 ,25(16):3697.
  • Chin Med.2022, 17(1):66.
  • JPC-Journal of Planar Chromatography 2017, 30(4)
  • PLoS One.2018, 13(11):e0208055
  • Journal of Food Quality2022, P:13, 6256310.
  • ...
  • 生物活性
    Description: Cinnamaldehyde has vasodilator, anti-melanoma, hypoglycemic, hypolipidemic, and anticancer effects, it possesses anti-bacterial activity against both gram-positive and gram-negative bacteria. Cinnamaldehyde has toxicity and antifeedant activities against the grain storage insects, Tribolium castaneum (Herbst) and Sitophilus zeamais Motsch. Cinnamaldehyde inhibited the expression of VEGF and HIF-α.
    Targets: NOS | Calcium Channel | VEGFR | HIF | ATPase
    In vitro:
    Appl. Environ. Microb., 2004, 70(10):5750-5.
    Mechanisms of Bactericidal Action of Cinnamaldehyde against Listeria monocytogenes and of Eugenol against L. monocytogenes and Lactobacillus sakei[Reference: WebLink]
    The spice oil components eugenol and cinnamaldehyde possess activity against both gram-positive and gram-negative bacteria, but the mechanisms of action remain obscure. In broth media at 20°C, 5 mM eugenol or 30 mM cinnamaldehyde was bactericidal (>1-log reduction in the number of CFU per milliliter in 1 h) to Listeria monocytogenes. At a concentration of 6 mM eugenol was bactericidal to Lactobacillus sakei, but treatment with 0.5 M cinnamaldehyde had no significant effect.
    METHODS AND RESULTS:
    To investigate the role of interference with energy generation in the mechanism of action, the cellular and extracellular ATP levels of cells in HEPES buffer at 20°C were measured. Treatment of nonenergized L. monocytogenes with 5 mM eugenol, 40 mM cinnamaldehyde, or 10 μM carbonyl cyanide m-chlorophenylhydrazone (CCCP) for 5 min prevented an increase in the cellular ATP concentration upon addition of glucose. Treatment of energized L. monocytogenes with 40 mM cinnamaldehyde or 10 μM CCCP caused a rapid decline in cellular ATP levels, but 5 mM eugenol had no effect on cellular ATP. Treatment of L. sakei with 10 mM eugenol prevented ATP generation by nonenergized cells and had no effect on the cellular ATP of energized cells. CCCP at a concentration of 100 μM had no significant effect on the cellular ATP of L. sakei. No significant changes in extracellular ATP were observed.
    CONCLUSIONS:
    Due to their rapidity, effects on energy generation clearly play a major role in the activity of eugenol and cinnamaldehyde at bactericidal concentrations. The possible mechanisms of inhibition of energy generation are inhibition of glucose uptake or utilization of glucose and effects on membrane permeability.
    J. Stored Prod. Res., 1998, 34(34):11-7.
    Toxicity and antifeedant activities of cinnamaldehyde against the grain storage insects, Tribolium castaneum (Herbst) and Sitophilus zeamais Motsch.[Reference: WebLink]
    A methylene chloride extract of the spice, cinnamon, Cinnamomum aromaticum Nees, was shown to be insecticidal to Tribolium castaneum (Herbst) and Sitophilus zeamais Motsch.
    METHODS AND RESULTS:
    The contact, fumigant and antifeedant effects of cinnamaldehyde were tested against T. castaneum adults and larvae and S. zeamais adults. T. castaneum and S. zeamais adults showed similar susceptibility to the contact toxicity of cinnamaldehyde, both having an LC50 of 0.7 mg cm−2 and an LC95 of 0.9 mg cm−2. However, cinnamaldehyde had a higher level of fumigant toxicity to T. castaneum than to S. zeamais, with LC50 values of 0.28 and 0.54 mg cm−2, respectively, and LC95 values of 0.32 and 1.78 mg cm−2, respectively. T. castaneum adults were more susceptible than larvae to the contact and fumigant actions of cinnamaldehyde. The larvae became less susceptible to both contact and fumigant toxicity of cinnamaldehyde with age. A flour disk bioassay using no-choice tests was employed to study the antifeedant activity of cinnamaldehyde against the insects and effects on consumption and utilisation of food by the insects. Cinnamaldehyde had no significant (P > 0.05) effects on diet consumption and growth of T. castaneum adults and had no antifeedant action against them at concentrations of up to 13.6 mg g−1 food. However, this compound significantly (P < 0.05) reduced food consumption, growth and dietary utilisation in T. castaneum larvae, and had obvious antifeedant action against the larvae at concentrations of 27.2 and 54.4 mg g−1 food. For S. zeamais adults, it only significantly (P < 0.05) reduced food consumption at a concentration range of 6.8 to 13.6 mg g−1 food, but had no significant (P > 0.05) effects on the insects' growth and food utilisation.
    CONCLUSIONS:
    Antifeedant action was observed to increase with increasing cinnamaldehyde concentrations. The combined contact, fumigant and antifeedant properties of cinnamaldehyde make it a potentially useful grain protectant.
    In vivo:
    Phytomedicine. 2007 Jan;14(1):15-22.
    Cinnamaldehyde--a potential antidiabetic agent.[Pubmed: 17140783 ]
    Cinnamonum zeylanicum (cinnamon) is widely used in traditional system of medicine to treat diabetes in India.
    METHODS AND RESULTS:
    The present study was carried out to isolate and identify the putative antidiabetic compounds based on bioassay-guided fractionation; the compound identified decreased the plasma glucose levels. The active compound was purified by repeat column and structure of cinnamaldehyde was determined on the basis of chemical and physiochemical evidence. The LD(50) value of cinnamaldehyde was determined as 1850+/-37 mg/kg bw. Cinnamaldehyde was administered at different doses (5, 10 and 20 mg/kg bw) for 45 days to streptozotocin (STZ) (60 mg/kg bw)-induced male diabetic wistar rats. It was found that plasma glucose concentration was significantly (p<0.05) decreased in a dose-dependent manner (63.29%) compared to the control. In addition, oral administration of cinnamaldehyde (20 mg/kg bw) Cinnamonum zeylanicum (cinnamon) is widely used in traditional system of medicine to treat diabetes in India.
    METHODS AND RESULTS:
    The present study was carried out to isolate and identify the putative antidiabetic compounds based on bioassay-guided fractionation; the compound identified decreased the plasma glucose levels. The active compound was purified by repeat column and structure of cinnamaldehyde was determined on the basis of chemical and physiochemical evidence. The LD(50) value of cinnamaldehyde was determined as 1850+/-37 mg/kg bw. Cinnamaldehyde was administered at different doses (5, 10 and 20 mg/kg bw) for 45 days to streptozotocin (STZ) (60 mg/kg bw)-induced male diabetic wistar rats. It was found that plasma glucose concentration was significantly (p<0.05) decreased in a dose-dependent manner (63.29%) compared to the control. In addition, oral administration of cinnamaldehyde (20 mg/kg bw) significantly decreased glycosylated hemoglobin (HbA(1C)), serum total cholesterol, triglyceride levels and at the same time markedly increased plasma insulin, hepatic glycogen and high-density lipoprotein-cholesterol levels. Also cinnamaldehyde restored the altered plasma enzyme (aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, alkaline phosphatase and acid phosphatase) levels to near normal. Administration of glibenclamide, a reference drug (0.6 mg/kg bw) also produced a significant (p<0.05) reduction in blood glucose concentration in STZ-induced diabetic rats.
    CONCLUSIONS:
    The results of this experimental study indicate that cinnamaldehyde possesses hypoglycemic and hypolipidemic effects in STZ-induced diabetic rats.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 7.5643 mL 37.8215 mL 75.643 mL 151.2859 mL 189.1074 mL
    5 mM 1.5129 mL 7.5643 mL 15.1286 mL 30.2572 mL 37.8215 mL
    10 mM 0.7564 mL 3.7821 mL 7.5643 mL 15.1286 mL 18.9107 mL
    50 mM 0.1513 mL 0.7564 mL 1.5129 mL 3.0257 mL 3.7821 mL
    100 mM 0.0756 mL 0.3782 mL 0.7564 mL 1.5129 mL 1.8911 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    肉桂醛; Cinnamaldehyde CFN99478 104-55-2 C9H8O = 132.2 20mg QQ客服:1413575084
    3-(2-羟基苯基)-2-丙烯醛; 3-(2-Hydroxyphenyl)-2-propenal CFN97017 60125-23-7 C9H8O2 = 148.2 5mg QQ客服:2159513211
    2'-甲氧基肉桂醛; o-Methoxycinnamaldehyde CFN93299 1504-74-1 C10H10O2 = 162.2 20mg QQ客服:215959384
    4-甲氧基肉桂醛; 4-Methoxycinnamaldehyde CFN90559 1963-36-6 C10H10O2 = 162.19 20mg QQ客服:215959384
    松柏醛; Coniferaldehyde CFN98037 20649-42-7 C10H10O3 = 178.2 5mg QQ客服:2159513211
    芥子醛; Sinapaldehyde CFN98038 20649-43-8 C11H12O4 = 208.2 10mg QQ客服:1413575084
    3-甲氧基-4,5-亚甲基二氧基肉桂醛; 3-Methoxy-4,5-methylenedioxycinnamaldehyde CFN97228 74683-19-5 C11H10O4 = 206.2 5mg QQ客服:2159513211

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