Info: Read More
  • 中药标准品生产商,产品定制服务
  • Chiisanoside

    Chiisanoside

    Chiisanoside
    产品编号 CFN90571
    CAS编号 89354-01-8
    分子式 = 分子量 C48H74O19 = 955.10
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Triterpenoids
    植物来源 The herbs of Acanthopanax brachypus Harms
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    Chiisanoside CFN90571 89354-01-8 1mg QQ客服:2159513211
    Chiisanoside CFN90571 89354-01-8 5mg QQ客服:2159513211
    Chiisanoside CFN90571 89354-01-8 10mg QQ客服:2159513211
    Chiisanoside CFN90571 89354-01-8 20mg QQ客服:2159513211
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Universidad Miguel Hernández (Spain)
  • Universidad de La Salle (Mexico)
  • University of Stirling (United Kingdom)
  • Griffith University (Australia)
  • Warszawski Uniwersytet Medyczny (Poland)
  • Max-Planck-Insitut (Germany)
  • Yale University (USA)
  • University of Wisconsin-Madison (USA)
  • Kamphaengphet Rajabhat University (Thailand)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Monash University (Australia)
  • Biotech R&D Institute (USA)
  • Seoul National University of Science and Technology (Korea)
  • Periyar University (India)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Applied Biological Chemistry2021, 64(4)
  • Antioxidants (Basel).2020, 9(2): E119
  • Oncotarget.2017, 9(3):4161-4172
  • Toxicol Mech Methods.2021, 1-12.
  • Phytomedicine.2018, 38:12-23
  • Int J Mol Sci.2022, 23(23):14545.
  • J Adv Res.2019, 17:85-94
  • Biosci Biotechnol Biochem.2021, 85(10):2153-2160.
  • J Chromatogr A.2017, 1518:46-58
  • Cell Physiol Biochem.2017, 44(4):1381-1395
  • Fitoterapia.2021, 153:104995.
  • Journal of Apicultural Research2021, 60(1)
  • Anal Sci.2019, 35(12):1317-1325
  • Sci Rep. 2017, 12953(7)
  • LWT-Food Science and Technology2017, 75:488-496
  • Food and Bioprocess Technology2017, 10(6):1074-1092
  • Nutr Res Pract.2020, 14(3):203-217.
  • Front Plant Sci.2021, 12: 648426.
  • Evid Based Complement Alternat Med.2020, 2020:8582318.
  • Evid Based Complement Alternat Med.2021, 8707280.
  • Toxins (Basel).2022, 14(12):824.
  • Appl. Sci.2020, 10(4),1304
  • Anticancer Res.2021, 41(3):1357-1364.
  • ...
  • 生物活性
    Description: Chiisanoside has anti-oxidant, anti-inflammatory, anti-rotaviral activities, it can inhibit xanthine oxidase activity and increase superoxide dismutase (SOD), glutathione peroxidase and catalase, it also inhibits NO and PGE2 production. Chiisanoside has the potential to prevent obesity as a lipase inhibitor which suppresses fat absorption in vivo.
    Targets: NO | PGE | TNF-α | NOS | COX | NF-kB | IL Receptor | p65 | ERK | JNK | ATPase | Potassium Channel | SOD | ROS
    In vitro:
    Biol Pharm Bull. 2005 Oct;28(10):1919-24.
    Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide and cyclooxygenase-2 by chiisanoside via suppression of nuclear factor-kappaB activation in RAW 264.7 macrophage cells.[Pubmed: 16204946]

    METHODS AND RESULTS:
    In the present study, the effects of several triterpenes isolated from the leaves of Acanthopanax chiisanensis (Araliaceae), namely, chiisanoside, isochiisanoside, 22-hydroxychiisanoside and chiisanogenin (the aglycone of chiisanoside) were evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production by the RAW 264.7 macrophage cell line. Of the triterpenes tested, chiisanoside was found to most potently inhibit NO and PGE2 production. In addition, chiisanoside significantly reduced the release of inflammatory cytokines like TNF-alpha and IL-1beta. Consistent with these observations, the protein and mRNA expression levels of iNOS and COX-2 enzyme were found to be inhibited by chiisanoside in a concentration-dependent manner. Furthermore, chiisanoside inhibited the nuclear factor-kappaB (NF-kappaB) activation induced by LPS and this was associated with a reduction in p65 protein in the nucleus and with the phosphorylations of ERK1/2 and JNK MAP kinases.
    CONCLUSIONS:
    Taken together, our data indicate that the anti-inflammatory properties of chiisanoside might be the result from the inhibition of iNOS, COX-2, TNF-alpha and IL-1beta expression through the down-regulation of NF-kappaB binding activity.
    Biol Pharm Bull. 2001 May;24(5):582-5.
    Metabolism of chiisanoside from Acanthopanax divaricatus var. albeofructus by human intestinal bacteria and its relation to some biological activities.[Pubmed: 11379786]

    METHODS AND RESULTS:
    The metabolic pathway of Chiisanoside isolated from leaves of Acanthopanax divaricatus var. albeofructus (Araliaceae) by human intestinal bacteria and by the protein fraction of leaves of this plant were investigated, and the cytotoxic and anti-rotaviral activities of Chiisanoside and its metabolite, chiisanogenin, were assayed. Chiisanogenin was produced as a main metabolite, when Chiisanoside were incubated for 15 h with human intestinal bacteria. This metabolic pathway proceeded more potently with the protein fraction than with human intestinal bacteria.
    CONCLUSIONS:
    The in vitro cytotoxicity of chiisanogenin was superior to that of Chiisanoside. H+/K+ ATPase was more potently inhibited by chiisanogenin than by Chiisanoside. However, the anti-rotaviral activity of Chiisanoside was more potent than that of chiisanogenin.
    In vivo:
    Biosci Biotechnol Biochem. 2008 Apr;72(4):1126-9.
    Chiisanoside is not absorbed but inhibits oil absorption in the small intestine of rodents.[Pubmed: 18391464]

    METHODS AND RESULTS:
    Chiisanoside is the main component of Acanthopanax sessiliflorus leaves. Simultaneous administration of chiisanoside resulted in a decrease in the plasma TG level and increase of undigested TG in the intestinal lumen after oil gavage to mice.
    CONCLUSIONS:
    This suggests that chiisanoside has the potential to prevent obesity as a lipase inhibitor which suppresses fat absorption in vivo.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.047 mL 5.2351 mL 10.4701 mL 20.9402 mL 26.1753 mL
    5 mM 0.2094 mL 1.047 mL 2.094 mL 4.188 mL 5.2351 mL
    10 mM 0.1047 mL 0.5235 mL 1.047 mL 2.094 mL 2.6175 mL
    50 mM 0.0209 mL 0.1047 mL 0.2094 mL 0.4188 mL 0.5235 mL
    100 mM 0.0105 mL 0.0524 mL 0.1047 mL 0.2094 mL 0.2618 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    1-脱羧-3-氧代茶酸; 1-Decarboxy-3-oxo-ceanothic acid CFN98072 214150-74-0 C29H44O3 = 440.7 5mg QQ客服:1457312923
    美洲茶酸; Ceanothic acid CFN98063 21302-79-4 C30H46O5 = 486.7 5mg QQ客服:2056216494
    乙酸茶酸酯; Ceanothic acid acetate CFN99309 119533-63-0 C32H48O6 = 528.7 5mg QQ客服:215959384
    3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid; 3,4-Secolupa-4(23),20(29)-diene-3,28-dioic acid CFN96940 36138-41-7 C30H46O4 = 470.69 5mg QQ客服:2159513211
    Chiisanoside; Chiisanoside CFN90571 89354-01-8 C48H74O19 = 955.10 5mg QQ客服:2159513211

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产