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  • 鼠尾草酚

    Carnosol

    鼠尾草酚
    产品编号 CFN99956
    CAS编号 5957-80-2
    分子式 = 分子量 C20H26O4 = 330.42
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Rosmarinus officinalis L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鼠尾草酚 CFN99956 5957-80-2 10mg QQ客服:3257982914
    鼠尾草酚 CFN99956 5957-80-2 20mg QQ客服:3257982914
    鼠尾草酚 CFN99956 5957-80-2 50mg QQ客服:3257982914
    鼠尾草酚 CFN99956 5957-80-2 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • University of Madras (India)
  • Monash University (Australia)
  • Charles University in Prague (Czech Republic)
  • Center for protein Engineering (CIP) (Belgium)
  • University of Virginia (USA)
  • Florida A&M University (USA)
  • Seoul National University of Science and Technology (Korea)
  • University of Maryland School of Medicine (USA)
  • University of Oslo (Norway)
  • Chiang Mai University (Thailand)
  • Subang Jaya Medical Centre (Malaysia)
  • Griffith University (Australia)
  • John Innes Centre (United Kingdom)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Biochem Biophys Res Commun.2019, 518(4):732-738
  • Natural Product Communications2020, doi: 10.1177.
  • J Ethnopharmacol.2020, 269:113752.
  • Biosci. Rep.2020, 10.1024
  • Front Pharmacol.2019, 10:1355
  • Antioxidants (Basel).2020, 9(2):E99
  • Life Sci.2022, 298:120488.
  • Molecules.2019, 24(6):E1155
  • Korean Journal of Pharmacognosy.2019, 50(1):65-71
  • Food Chem.2019, 276:768-775
  • JABS2020, 14:2(2020)
  • Acta horticulturae2017, 1158:257-268
  • J Pharm Biomed Anal.2019, 172:268-277
  • J Pharm Biomed Anal.2018, 151:32-41
  • J Ethnopharmacol.2020, 249:112396
  • Eur J Pharmacol.2020, 889:173589.
  • J Enzyme Inhib Med Chem.2019, 34(1):134-143
  • Exp Parasitol.2018, 194:67-78
  • Appl Biol Chem2019, 62:46
  • Biomolecules.2021, 11(10):1537.
  • Int Immunopharmacol.2021, 100:108073.
  • Pharmacol Rep.2020, 72(2):472-480.
  • Int Immunopharmacol. 2020, 83:106403.
  • ...
  • 生物活性
    Description: Carnosol, a novel agonist of TRPA1 with an EC50 value of 12.46 uM, which exhibits anti-inflammatory, anti-nociceptive, hepatoprotective, antioxidant, anticarcinogen, anti-angiogenic, anti- invasive and antimetastatic properties. Carnosol can cause a significant decrease in both bacterial and yeast growth whilst, it may prove useful as a food antioxidant which could also contribute to the retardation of the microbial spoilage of foods; it also can inhibit adipocyte differentiation in mouse 3T3-L1 cells through induction of phase2 enzymes and activation of glutathione metabolism, it may be a potential drug against obesity-related diseases.
    Targets: Nrf2 | MMP(e.g.TIMP) | ERK | Akt | p38MAPK | JNK | NF-kB | AP-1 | NO | NOS | IkB | IKK | TRPA1
    In vitro:
    Eur J Nutr. 2013 Feb;52(1):85-95.
    Anti-angiogenic properties of carnosol and carnosic acid, two major dietary compounds from rosemary.[Pubmed: 22173778 ]
    The use of rosemary (Rosmarinus officinalis) leaves and their constituents as a source of dietary antioxidants and flavoring agents is continuously growing. Carnosol and carnosic acid, two major components of rosemary extracts, have shown activity for cancer prevention and therapy. In this study, we investigate the cytotoxic and anti-angiogenic activities of carnosol and carnosic acid, in order to get further insight into their mechanism of action.
    METHODS AND RESULTS:
    Our results demonstrate that the mentioned diterpenes inhibit certain functions of endothelial cells, namely, differentiation, proliferation, migration and proteolytic capability. Our data indicate that their growth inhibitory effect, exerted on proliferative endothelial and tumor cells, could be due to, at least in part, an induction of apoptosis. Inhibition of the mentioned essential steps of in vitro angiogenesis agrees with the observed inhibition of the in vivo angiogenesis, substantiated by using the chick chorioallantoic membrane assay.
    CONCLUSIONS:
    The anti-angiogenic activity of carnosol and carnosic acid could contribute to the chemopreventive, antitumoral and antimetastatic activities of rosemary extracts and suggests their potential in the treatment of other angiogenesis-related malignancies.
    Food Microbiol., 1987, 4(4):311-5.
    Antimicrobial activity of carnosol and ursolic acid: two anti-oxidant constituents of Rosmarinus officinalis L.[Reference: WebLink]

    METHODS AND RESULTS:
    Inhibition of the growth of 6 strains of food associated bacteria and yeasts by Carnosol and Ursolic acid, two antioxidant compounds extracted from rosemary, was investigated and compared to inhibitory effects exhibited by the commonly used food antioxidants Butylated Hydroxyanisole (BHA) and Butylated Hydroxytoluene (BHT). At the highest concentration used (150 μg ml−1) Carnosol inhibited all the test microbes to the greatest extent. BHA proved a superior inhibitor to Ursolic acid which itself was more effective overall than BHT. Even at 50 μg ml−1, Carnosol caused a significant decrease in both bacterial and yeast growth whilst BHA proved more effective against the yeasts than bacteria.
    CONCLUSIONS:
    Thus Carnosol might prove useful as a food antioxidant which could also contribute to the retardation of the microbial spoilage of foods.
    Oncotarget . 2018 Feb 6;9(76):34200-34212.
    Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2[Pubmed: 30344937]
    Abstract Carnosol is a phenolic diterpene that is isolated from rosemary, sage, and oregano. It has been reported to possess anti-oxidant, anti-inflammatory, and anti-cancer properties. However, the molecular mechanism of carnosol's activity against gastric cancer has not been investigated. Herein, we report that carnosol is an RSK2 inhibitor that attenuates gastric cancer growth. Carnosol reduced anchorage-dependent and -independent gastric cancer growth by inhibiting the RSKs-CREB signaling pathway. The results of in vitro screening and cell-based assays indicated that carnosol represses RSK2 activity and its downstream signaling. Carnosol increased the G2/M phase and decreased S phase cell cycle and also induced apoptosis through the activation of caspases 9 and 7 and inhibition of Bcl-xL expression. Notably, oral administration of carnosol suppressed patient-derived gastric tumor growth in an in vivo mouse model. Our findings suggest that carnosol is an RSK2 inhibitor that could be useful for treating gastric cancer. Keywords: RSK2; carnosol; gastric cancer; patient-derived tumor xenograft.
    Int J Mol Sci . 2019 Feb 18;20(4):880.
    Carnosol as a Nrf2 Activator Improves Endothelial Barrier Function Through Antioxidative Mechanisms[Pubmed: 30781644]
    Abstract Oxidative stress is the main pathogenesis of diabetic microangiopathy, which can cause microvascular endothelial cell damage and destroy vascular barrier. In this study, it is found that carnosol protects human microvascular endothelial cells (HMVEC) through antioxidative mechanisms. First, we measured the antioxidant activity of carnosol. We showed that carnosol pretreatment suppressed tert-butyl hydroperoxide (t-BHP)-induced cell viability, affected the production of lactate dehydrogenase (LDH) as well as reactive oxygen species (ROS), and increased the produce of nitric oxide (NO). Additionally, carnosol promotes the protein expression of vascular endothelial cadherin (VE-cadherin) to keep the integrity of intercellular junctions, which indicated that it protected microvascular barrier in oxidative stress. Meanwhile, we investigated that carnosol can interrupt Nrf2-Keap1 protein-protein interaction and stimulated antioxidant-responsive element (ARE)-driven luciferase activity in vitro. Mechanistically, we showed that carnosol promotes the expression of heme oxygenase 1(HO-1) and nuclear factor-erythroid 2 related factor 2(Nrf2). It can also promote the expression of endothelial nitric oxide synthase (eNOS). Collectively, our data support the notion that carnosol is a protective agent in HMVECs and has the potential for therapeutic use in the treatments of microvascular endothelial cell injury. Keywords: HMVEC cells; antioxidant activity; carnosol; microvascular endothelial protection.
    In vivo:
    Eur J Gastroenterol Hepatol. 2002 Sep;14(9):1001-6.
    Protective effect of carnosol on CCl(4)-induced acute liver damage in rats.[Pubmed: 12352220]
    We recently reported that (Lamiaceae) may alleviate CCl(4)-induced acute hepatotoxicity in rats, possibly blocking the formation of free radicals generated during CCl(4) metabolism. Carnosol, one of the main constituents of Rosmarinus, has been shown to have antioxidant and scavenging activities. Therefore, it is plausible to expect that carnosol may mediate some of the effects of Rosmarinus on oxidative stress consequences induced by CCl(4) in the liver. We evaluated the effectiveness of carnosol to normalize biochemical and histological parameters of CCl(4)-induced acute liver injury.
    METHODS AND RESULTS:
    Male Sprague Dawley rats (n = 5) injured by CCl(4) (oral dose 4 g/kg of body weight) were treated with a single intraperitoneal dose (5 mg/kg) of carnosol. Twenty-four hours later, the rats were anaesthetized deeply to obtain the liver and blood, and biochemical and histological parameters of liver injury were evaluated. Carnosol normalized bilirubin plasma levels, reduced malondialdehyde (MDA) content in the liver by 69%, reduced alanine aminotransferase (ALT) activity in plasma by 50%, and partially prevented the fall of liver glycogen content and distortion of the liver parenchyma.
    CONCLUSIONS:
    Carnosol prevents acute liver damage, possibly by improving the structural integrity of the hepatocytes. To achieve this, carnosol could scavenge free radicals induced by CCl(4), consequently avoiding the propagation of lipid peroxides. It is suggested that at least some of the beneficial properties of Rosmarinus officinalis are due to carnosol.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.0265 mL 15.1323 mL 30.2645 mL 60.529 mL 75.6613 mL
    5 mM 0.6053 mL 3.0265 mL 6.0529 mL 12.1058 mL 15.1323 mL
    10 mM 0.3026 mL 1.5132 mL 3.0265 mL 6.0529 mL 7.5661 mL
    50 mM 0.0605 mL 0.3026 mL 0.6053 mL 1.2106 mL 1.5132 mL
    100 mM 0.0303 mL 0.1513 mL 0.3026 mL 0.6053 mL 0.7566 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    鼠尾草酚; Carnosol CFN99956 5957-80-2 C20H26O4 = 330.42 20mg QQ客服:1457312923
    异迷迭香酚; Isorosmanol CFN93009 93780-80-4 C20H26O5 = 346.42 5mg QQ客服:2159513211
    迷迭香酚; Rosmanol CFN93024 80225-53-2 C20H26O5 = 344.45 10mg QQ客服:2056216494
    Rosmaquinone; Rosmaquinone CFN91824 121927-71-7 C20H24O5 = 344.4 5mg QQ客服:1457312923
    7alpha-甲氧基迷迭香酚 ; 7-O-Methylrosmanol CFN96974 113085-62-4 C21H28O5 = 360.45 10 mg QQ客服:2159513211
    7beta-甲氧基迷迭香酚 ; 7beta-Methoxyrosmanol CFN92990 24703-38-6 C21H28O5 = 360.44 5mg QQ客服:215959384
    7-乙氧基迷迭香酚; 7-Ethoxyrosmanol CFN91119 111200-01-2 C22H30O5 = 374.5 10mg QQ客服:215959384
    鼠尾草酸; Carnosic acid CFN99102 3650-09-7 C20H28O4 = 332.43 20mg QQ客服:2056216494
    12-O-甲基鼠尾草酸; 12-O-Methylcarnosic acid CFN89377 62201-71-2 C21H30O4 = 346.46 5mg QQ客服:215959384
    11-Hydroxy-12-methoxyabietatriene; 11-Hydroxy-12-methoxyabietatriene CFN92286 16755-54-7 C21H32O2 = 316.5 5mg QQ客服:2159513211

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