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  • 喜树碱

    Camptothecin

    喜树碱
    产品编号 CFN97249
    CAS编号 7689-03-4
    分子式 = 分子量 C20H16N2O4 = 348.4
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Alkaloids
    植物来源 The barks of Camptotheca acuminata Decne.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    喜树碱 CFN97249 7689-03-4 10mg QQ客服:2159513211
    喜树碱 CFN97249 7689-03-4 20mg QQ客服:2159513211
    喜树碱 CFN97249 7689-03-4 50mg QQ客服:2159513211
    喜树碱 CFN97249 7689-03-4 100mg QQ客服:2159513211
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Hawaii Cancer Center (USA)
  • Kamphaengphet Rajabhat University (Thailand)
  • Instituto Politécnico de Bragan?a (Portugal)
  • National Cancer Institute (USA)
  • S.N.D.T. Women's University (India)
  • Chungnam National University (Korea)
  • Korea Food Research Institute(KFRI) (Korea)
  • University of Hull (United Kingdom)
  • Complutense University of Madrid (Spain)
  • Kitasato University (Japan)
  • Universita' Degli Studi Di Cagliari (Italy)
  • Korea Institute of Oriental Medicine (Korea)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • University of Wisconsin-Madison (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Molecules.2015, 20(11):20014-30
  • Int J Mol Sci.2023, 24(5):4505.
  • Nutrients.2023, 15(3):753.
  • J Sci Food Agric.2023, 103(1):213-220.
  • J Food Sci.2022, 87(11):4905-4916.
  • Int J Mol Sci.2023, 24(7):6360.
  • Environ Toxicol.2019, 34(4):513-520.
  • Mol Med Rep.2015, 12(5):7789-95
  • Molecules.2021, 26(23):7390.
  • J Anal Methods Chem.2022, 2022:2229500.
  • BMB Rep.2020, 53(4):218-222.
  • Food Analytical Methods2017, 10:3225-3234
  • Molecules.2023, 28(8):3503.
  • PLoS One.2017, 12(3):e0173585
  • Chemistry of Natural Compounds2020, 56,423-426
  • Food Sci Nutr.2023, 11(9):5532-5542.
  • J Cell Mol Med.2020, 24(21):12308-12317.
  • Sci Rep.2019, 9(1):6429
  • J Nat Prod.2021, 84(9):2544-2553.
  • Food Chem.2021, 360:130063.
  • Front Pharmacol.2021, 12:744624.
  • Antioxidants (Basel).2024, 13(3):340.
  • J Ethnopharmacol.2021, 267:113615.
  • ...
  • 生物活性
    Description: Camptothecin is a specific inhibitor of DNA topoisomerase I (Topo I) with IC50 of 0.68 μM; it is a novel alkaloidal leukemia and tumor inhibitor, is a strong inhibitor of nucleic acid synthesis in mammalian cells and a potent inducer of strand breaks in chromosomal DNA. Camptothecin and its analogs reduce amyloid-β production and amyloid-β42-induced IL-1β production.
    Targets: Beta Amyloid | p53 | IL Receptor | Topoisomerase
    In vitro:
    J Alzheimers Dis. 2015;43(2):465-77.
    Camptothecin and its analogs reduce amyloid-β production and amyloid-β42-induced IL-1β production.[Pubmed: 25096614]
    Compounds derived from natural products are becoming promising alternative drugs/tools in Alzheimer's disease (AD) therapeutics.
    METHODS AND RESULTS:
    From an in-house natural products library, seventeen hits were selected for their inhibitory effect on the production of amyloid-β (Aβ) with IC50 lower than 10 μM without causing obvious toxicity. Among these compounds, camptothecin (CPT) and its analogs showed inhibitory effects on amyloid-β 1-42 (Aβ42) with the IC50 value in the nanomolar range in HEKsw cells and SHSY5Ysw cells. Further studies showed that CPT and its analogs inhibited Aβ42 via a p53 dependent pathway. Meanwhile, CPT and its analogs could also inhibit Aβ42 induced IL-1β production in the THP-1 cells.
    CONCLUSIONS:
    Taken together, our results indicate that CPT and its analogs would be a promising therapeutic candidates for AD.
    In vivo:
    J Drug Target. 2014 Dec;22(10):913-26.
    Development and evaluation of magnetic microemulsion: tool for targeted delivery of camptothecin to BALB/c mice-bearing breast cancer.[Pubmed: 25119147]
    Development and evaluation of camptothecin-loaded-microemulsion (ME) and -magnetic microemulsion (MME) for passive/active-targeted delivery to BALB/c mice-bearing breast cancer.
    METHODS AND RESULTS:
    Based on the pseudo-ternary phase diagrams camptothecin-loaded-MEs and -MMEs were developed using benzyl alcohol:Captex 300 (3:1), TPGS:Tween 80 (2:1) and water. Furthermore, characterized for their droplet size distribution, magnetic susceptibility and effect of droplet size in plasma and evaluated for in vitro and in vivo targeting potential, drug release, haemolytic potential, cytotoxicity, genotoxicity, in vivo biodistribution and lactone ring stability. Drug-loaded MEs showed uniform droplet distribution, extended drug release (76.07 ± 4.30% at 24 h), acceptable level of haemolytic activity (<20%), significant cytotoxicity (129 ± 3.9 ng/mL) against MCF-7 cancer cells and low DNA damage in lymphocytes. Targeting potential of MMEs was documented in 4T1 breast cancer-induced BALB/c mice. MMEs were concentrated more at the target tissue on introduction of external magnetic field. In vivo biodistribution study documented the active targeting of 5067.56 ± 354.72 ng/gm and passive targeting of 1677.58 ± 134.20 ng/gm camptothecin to breast cancer from MME and ME, respectively. Lactone stability study shows around 80% of the lactone stable at 24 h.
    CONCLUSIONS:
    Developed ME and MME may act as a promising nanocarrier for efficient targeting of breast cancer tissues.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.8703 mL 14.3513 mL 28.7026 mL 57.4053 mL 71.7566 mL
    5 mM 0.5741 mL 2.8703 mL 5.7405 mL 11.4811 mL 14.3513 mL
    10 mM 0.287 mL 1.4351 mL 2.8703 mL 5.7405 mL 7.1757 mL
    50 mM 0.0574 mL 0.287 mL 0.5741 mL 1.1481 mL 1.4351 mL
    100 mM 0.0287 mL 0.1435 mL 0.287 mL 0.5741 mL 0.7176 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    9-氨基喜树碱; 9-Aminocamptothecin CFN90309 91421-43-1 C20H17N3O4 = 363.37 20mg QQ客服:215959384
    (S)-10-羟基喜树碱; (S)-10-Hydroxycamptothecin CFN99735 19685-09-7 C20H16N2O5 = 364.35 20mg QQ客服:215959384
    10-甲氧基喜树碱; 10-Methoxycamptothecin CFN90157 19685-10-0 C21H18N2O5 = 378.38 5mg QQ客服:3257982914
    鲁比替康; Rubitecan CFN93013 91421-42-0 C20H15N3O6 = 393.35 5mg QQ客服:2056216494
    10-硝基喜树碱; 10-Nitro-camptothecin CFN90439 104195-61-1 C20H15N3O6 = 393.34 5mg QQ客服:215959384
    盐酸拓扑替康; Topotecan hydrochloride CFN90462 119413-54-6 C23H24ClN3O5 = 457.9 20mg QQ客服:2056216494
    盐酸依立替康; Irinotecan hydrochloride CFN90886 100286-90-6 C33H39ClN4O6 = 623.2 20mg QQ客服:1413575084
    7-乙基喜树碱; 7-Ethylcamptothecin CFN90336 78287-27-1 C22H20N2O4 = 376.41 20mg QQ客服:2056216494
    7-乙基-10-羟基喜树碱; 7-Ethyl-10-Hydroxycamptothecin CFN90335 86639-52-3 C22H20N2O5 = 392.4 20mg QQ客服:3257982914
    9-甲氧基喜树碱; 9-Methoxycamptothecine CFN99729 39026-92-1 C21H18N2O5 = 378.38 20mg QQ客服:1413575084

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