(S)-10-羟基喜树碱

(S)-10-Hydroxycamptothecin

	产品编号	CFN99735
	CAS编号	19685-09-7
	分子式 = 分子量	C₂₀H₁₆N₂O₅ = 364.35
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The barks of Camptotheca acuminata Decne.
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产品名称	产品编号	CAS编号	包装	QQ客服
(S)-10-羟基喜树碱	CFN99735	19685-09-7	10mg	QQ客服：3257982914
(S)-10-羟基喜树碱	CFN99735	19685-09-7	20mg	QQ客服：3257982914
(S)-10-羟基喜树碱	CFN99735	19685-09-7	50mg	QQ客服：3257982914
(S)-10-羟基喜树碱	CFN99735	19685-09-7	100mg	QQ客服：3257982914

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Northeast Normal University Changchun (China)

Amity University (India)

Srinakharinwirot University (Thailand)

University of Beira Interior (Portugal)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

Institute of Tropical Disease Universitas Airlangga (Indonesia)

Siksha O Anusandhan University (India)

Universitas Airlangga (Indonesia)

Tokyo Woman's Christian University (Japan)

Sri Ramachandra University (India)

Universidad Veracuzana (Mexico)

Calcutta University (India)

University of Helsinki (Finland)

Medical University of Gdansk (Poland)

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Description:

(S)-10-Hydroxycamptothecin is a DNA topoisomerase I inhibitor, it is a clinical therapy agent against hepatoma.

Targets:

TNF-α | P450 (e.g. CYP17) | Topoisomerase

In vivo:

Cancer Treat Rep. 1983 Feb;67(2):179-82.

Action of (S)-10-hydroxycamptothecin on P388 leukemia and distribution of the drug in mice.[Pubmed: 6825126]

METHODS AND RESULTS:
As an inhibitor of the growth of P388 leukemia in mice, (S)-10-Hydroxycamptothecin (OPT) was as potent as the parent compound camptothecin (CPT). Incorporation of thymidine into DNA was the parameter most sensitive to OPT in vitro (ED50 approximately 4 micrograms/ml), but incorporation of cytidine into RNA and of acetate into lipids was also reduced significantly in the presence of the drug. The cytofluorometric profile suggested suppression of the S and G2/M phases. The distribution of OPT in mice at 2 and 24 hours after ip injection (10 mg/kg) was essentially similar to that of CPT, with the exception of a somewhat greater concentration of CPT in the liver.
CONCLUSIONS:
In their pharmacology, OPT and CPT appear to be very similar, despite reports that the hydroxy derivative is less toxic.

Anticancer Res. 1981;1(2):115-9.

Anti-tumor effect of (S)-10-hydroxycamptothecin on mouse hepatoma BW7756 and its possible mode of action.[Pubmed: 7347154]

METHODS AND RESULTS:
(S)-10-Hydroxycamptothecin (OPT), an analog of camptothecin (CPT), was found to inhibit the growth of the mouse hepatoma BW7756, when given at 1.0 mg/kg/day for 14 days. Cell cycle studies using flow cytofluorometry indicated that this drug inhibited the S-Phase of the tumor cells in vivo and the S and G2/M phases in vitro. Similar studies on host liver showed little or no effect. In spite of the narrow range of the effective dose of this drug against mouse hepatoma BW7756, the use of OPT in combination with other antitumor agents may be useful in primary hepatoma or liver metastases in view of its low toxicity towards host liver.
CONCLUSIONS:
A simple cytofluorometric method useful for live cell cycle study has been adapted for this investigation and can be adopted for other drug studies.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
鲁比替康; Rubitecan	CFN93013	91421-42-0	C₂₀H₁₅N₃O₆ = 393.35	5mg	QQ客服：2159513211
10-硝基喜树碱; 10-Nitro-camptothecin	CFN90439	104195-61-1	C₂₀H₁₅N₃O₆ = 393.34	5mg	QQ客服：1457312923
盐酸拓扑替康; Topotecan hydrochloride	CFN90462	119413-54-6	C₂₃H₂₄ClN₃O₅ = 457.9	20mg	QQ客服：2056216494
盐酸依立替康; Irinotecan hydrochloride	CFN90886	100286-90-6	C₃₃H₃₉ClN₄O₆ = 623.2	20mg	QQ客服：2056216494
7-乙基喜树碱; 7-Ethylcamptothecin	CFN90336	78287-27-1	C₂₂H₂₀N₂O₄ = 376.41	20mg	QQ客服：2056216494
7-乙基-10-羟基喜树碱; 7-Ethyl-10-Hydroxycamptothecin	CFN90335	86639-52-3	C₂₂H₂₀N₂O₅ = 392.4	20mg	QQ客服：1457312923
9-甲氧基喜树碱; 9-Methoxycamptothecine	CFN99729	39026-92-1	C₂₁H₁₈N₂O₅ = 378.38	20mg	QQ客服：2056216494
9-氨基喜树碱; 9-Aminocamptothecin	CFN90309	91421-43-1	C₂₀H₁₇N₃O₄ = 363.37	20mg	QQ客服：1457312923
(S)-10-羟基喜树碱; (S)-10-Hydroxycamptothecin	CFN99735	19685-09-7	C₂₀H₁₆N₂O₅ = 364.35	20mg	QQ客服：2056216494
10-甲氧基喜树碱; 10-Methoxycamptothecin	CFN90157	19685-10-0	C₂₁H₁₈N₂O₅ = 378.38	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7446 mL	13.7231 mL	27.4461 mL	54.8923 mL	68.6153 mL
5 mM	0.5489 mL	2.7446 mL	5.4892 mL	10.9785 mL	13.7231 mL
10 mM	0.2745 mL	1.3723 mL	2.7446 mL	5.4892 mL	6.8615 mL
50 mM	0.0549 mL	0.2745 mL	0.5489 mL	1.0978 mL	1.3723 mL
100 mM	0.0274 mL	0.1372 mL	0.2745 mL	0.5489 mL	0.6862 mL