| In vitro: |
| Phytochemistry. 2008 Sep;69(12):2367-73. | | Sesquiterpenoids from Homalomena occulta affect osteoblast proliferation, differentiation and mineralization in vitro.[Pubmed: 18649899 ] |
METHODS AND RESULTS:
Chemical investigation of rhizomes of Homalomena occulta (Lours) resulted in isolation and identification of two sesquiterpenoids (6,7), and one daucane ester 8, together with five known sesquiterpenoids, oplodiol, oplopanone, homalomenol C, Bullatantriol, and 1beta,4beta,7alpha-trihydroxyeudesmane. Their structures were elucidated using 1D and 2D NMR spectroscopic and X-ray analyses. The chloroform extract of this plant and compounds 1-7 were tested in vitro for their activities in stimulating osteoblast (OB) proliferation, differentiation and mineralization.
CONCLUSIONS:
Compounds 1-4 had a stimulative effect on significantly proliferation and differentiation of culture osteoblasts, while the chloroform extract and 1 significantly stimulated mineralization of cultured osteoblasts in vitro. | | Chem Biodivers. 2007 May;4(5):925-31. | | Three new sesquiterpenoids from the aerial parts of Homalomena occulta.[Pubmed: 17511005 ] |
METHODS AND RESULTS:
Three new eudesmane-type sesquiterpenoids, compounds 1-3, and eight known constituents, including mucrolidin (4), 1beta,4beta,7alpha-trihydroxyeudesmane (5), 1beta,4beta,6beta,11-tetrahydroxyeudesmane (6), oplodiol (7), Bullatantriol (8), acetylBullatantriol (9), homalomenol (10), and maristeminol (11), were isolated from the aerial parts of Homalomena occulta. Their structures were determined by interpretation of spectroscopic and mass-spectrometric data, and their antimicrobial activities toward six different bacterial strains were tested.
CONCLUSIONS:
Most of the compounds showed weak antibacterial activities in an agar-diffusion assay. |
|
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