士的宁

Strychnine

	产品编号	CFN98130
	CAS编号	57-24-9
	分子式 = 分子量	C₂₁H₂₂N₂O₂ = 334.41
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The seeds of Strychnos nu r-vomica L.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
士的宁	CFN98130	57-24-9	10mg	QQ客服：3257982914
士的宁	CFN98130	57-24-9	20mg	QQ客服：3257982914
士的宁	CFN98130	57-24-9	50mg	QQ客服：3257982914
士的宁	CFN98130	57-24-9	100mg	QQ客服：3257982914

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Description:

Strychnine-insensitive glycine site NMDA antagonist ( R )-HA-966 have neuroprotective effects in an experimental model of Parkinson's disease. Strychnine insensitive glycine receptor has anticonvulsant properties.Strychnine can block binaural inhibition in lateral superior olivary neurons, decrease the voltage-dependent Ca2+ current of both Aplysia and frog ganglion neurons. Strychnine also has inhibitory effects on GABA- and glycine-induced responses.

Targets:

Calcium Channel | Sodium Channel | ATPase | Potassium Channel | GABA Receptor

In vitro:

Brain Res. 1991 Oct 4;561(1):77-83.

Differential blockade of bicuculline and strychnine on GABA- and glycine-induced responses in dissociated rat hippocampal pyramidal cells.[Pubmed: 1797352]

METHODS AND RESULTS:
The inhibitory effects of bicuculline (BIC) and strychnine (STR) on GABA- and glycine-induced responses were studied in the rat dissociated hippocampal CA1 pyramidal neurons in whole-cell mode by using the conventional patch-clamp technique. Both GABA and glycine elicited inward Cl- currents in a dose-dependent manner and had almost the same maximal responses. The half-maximum dose (Ka) and Hill coefficient were 6.4 microM and 1.1 for the GABA response, and 74 microM and 1.5 for the glycine response. BIC and STR antagonized both GABA and glycine responses in a competitive manner. The blocking potency of BIC and STR on the GABA response was comparable. The half inhibition dose (IC50) was 2.7 microM for BIC and 6.7 microM for STR. STR blocked the glycine response about 3,000 x more effectively than BIC. The IC50 was 28 nM for STR and 100 microM for BIC. The BIC and STR did not have voltage-dependent blocking effects on either GABA or glycine responses.
CONCLUSIONS:
Neither GABA nor glycine showed outward rectification in their current-voltage relationships. The functional role of glycine in the rat hippocampal CA1 region is discussed.

In vivo:

Eur J Pharmacol. 1989 Dec 19;174(2-3):197-204.

A potent antagonist of the strychnine insensitive glycine receptor has anticonvulsant properties.[Pubmed: 2560979]

METHODS AND RESULTS:
5.7-Dinitro-quinoxaline-2.3-dione (MNQX) displaced [3H]glycine binding to cortical membranes but had no effect n [3H]3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid ([3H]CPP) binding. MNQX potently antagonized N-methyl-D-aspartate (NMDA)-evoked release of [3H]GABA from cultured cortical neurones, NMDA evoked spreading depression and NMDA depolarizations in the rat neo-cortex. All of these responses were reversed by addition of glycine to the perfusion media.
CONCLUSIONS:
These results suggested that MNQX is an antagonist at the strychnine-insensitive glycine receptor associated with the NMDA receptor/ionophore complex. Furthermore the compound was found to antagonise audiogenic seizures in DBA-2 mice indicating the potential of glycine antagonists of this type in anticonvulsant therapy.

Physiol. Behav., 1970, 5(12):1437-42.

Strychnine effects on discrimination learning in mice: Effects of dose and time of administration.[Reference: WebLink]

METHODS AND RESULTS:
Experiment 1 examined the dose response effects of posttrial injections of strychnine sulphate (0.012–1.25 mg/kg) on learning in mice. Injections were given each day immediately after 3 massed training trials on a food reward visual discrimination task. Facilitation was found with low (0.25, 0.05, 0.10 mg/kg) and high (1.0 and 1.25 mg/kg) doses, but not with intermediate doses (0.20, 0.40, 0.80 mg/kg). Experiment 2 examined the effects of time of pre- or posttrial drug injection of two doses: 0.10 and 1.00 mg/kg. With both doses significant facilitation of learning was obtained with posttrial injection intervals of one hour or less. With 1.0 mg/kg facilitation was obtained with all pretrial injection times examined (longest interval was 1 hr). With 0.10 mg/kg significant facilitation was obtained with injections given 30 min but not 60 min pretrial.
CONCLUSIONS:
These findings are interpreted as providing further evidence that strychnine facilitates learning by affecting posttrial neurobiological processes underlying memory storage.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9903 mL	14.9517 mL	29.9034 mL	59.8068 mL	74.7585 mL
5 mM	0.5981 mL	2.9903 mL	5.9807 mL	11.9614 mL	14.9517 mL
10 mM	0.299 mL	1.4952 mL	2.9903 mL	5.9807 mL	7.4759 mL
50 mM	0.0598 mL	0.299 mL	0.5981 mL	1.1961 mL	1.4952 mL
100 mM	0.0299 mL	0.1495 mL	0.299 mL	0.5981 mL	0.7476 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
马钱子碱; Brucine	CFN90244	357-57-3	C₂₃H₂₆N₂O₄ = 394.46	20mg	QQ客服：1457312923
硫酸马钱子碱; Brucine sulfate	CFN90316	4845-99-2	C₄₆H₅₄N₄O₁₂S = 887.01	20mg	QQ客服：3257982914
士的宁; Strychnine	CFN98130	57-24-9	C₂₁H₂₂N₂O₂ = 334.41	20mg	QQ客服：3257982914
番木鳖次碱; Vomicine	CFN96442	125-15-5	C₂₂H₂₄N₂O₄ = 380.4	5mg	QQ客服：1457312923
葫芦箭毒素，葫芦素; Calebassine	CFN90130	7257-29-6	C₄₂H₅₂N₄O₂ = 644.9	5mg	QQ客服：2159513211
长春花碱; Conophylline	CFN99473	142741-24-0	C₄₄H₅₀N₄O₁₀ = 794.9	5mg	QQ客服：2056216494

士的宁

Strychnine

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