鸦胆子苷 A

Bruceoside A

	产品编号	CFN95080
	CAS编号	63306-30-9
	分子式 = 分子量	C₃₂H₄₂O₁₆ = 682.7
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The seeds of Brucea javanica.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
鸦胆子苷 A	CFN95080	63306-30-9	1mg	QQ客服：215959384
鸦胆子苷 A	CFN95080	63306-30-9	5mg	QQ客服：215959384
鸦胆子苷 A	CFN95080	63306-30-9	10mg	QQ客服：215959384
鸦胆子苷 A	CFN95080	63306-30-9	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Aveiro University (Portugal)

VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)

University of Liège (Belgium)

Macau University of Science and Technology (China)

Chulalongkorn University (Thailand)

Universidad de Buenos Aires (Argentina)

Institute of Bioorganic Chemistry Polish Academy of Sciences (Poland)

University of Padjajaran (Indonesia)

Universit?t Basel (Switzerland)

Monash University Malaysia (Malaysia)

University of Beira Interior (Portugal)

Max-Planck-Insitut (Germany)

University of Illinois (USA)

Max Rubner-Institut (MRI) (Germany)

More...

Description:

Bruceoside A could be transformed into the potent anticancer component brusatol in vivo, rather than its direct deglycosylated metabolite bruceosin. It significantly inhibited P-388 lymphocytic leukemic cell RNA and protein synthesis in tissue culture.

Targets:

RNA synthesis

In vitro:

J Pharm Sci. 1979 Jul;68(7):883-7.

Antitumor agents. XXXIV: Mechanism of action of bruceoside A and brusatol on nucleic acid metabolism of P-388 lymphocytic leukemia cells.[Pubmed: 458610 ]

The quassinoids bruceantin, brucein D, brucein E, bruceoside A, and brusatol significantly inhibited P-388 lymphocytic leukemic cell RNA and protein synthesis in tissue culture. However, DNA synthesis inhibition seemed to correlate more directly with the anti-neoplastic activity of these compounds in the in vivo P-338 survival system.
METHODS AND RESULTS:
In vitro, brusatol and bruceoside A marginally inhibited 10-day P-388 lymphocytic leukemia DNA polymerase, RNA polymerase, thymidylate synthetase, dihydrofolate reductase, phosphoribosyl pyrophosphate aminotransferase, and cathepsin protease activities. In vivo studies demonstrated similar inhibition and elevated cyclic AMP levels, correlating positively with the antineoplastic activity of individual compounds. Purine synthesis was inhibited drastically by brusatol in vivo, and one key inhibition site in purine synthesis was at phosphoribosyl pyrophosphate aminotransferase, the regulatory enzyme.
CONCLUSIONS:
Histone phosphorylation and ribonucleotide reductase activity also were inhibited marginally by brusatol.

In vivo:

J Pharm Biomed Anal. 2019 Jun 5;170:264-272.

Pharmacokinetic study on bruceoside A revealed the potential role of quassinoid glycosides for the anticancer properties of Fructus Bruceae.[Pubmed: 30947127 ]

Bruceoside A, an abundant quassinoid glycoside in Fructus Bruceae, was chosen for the pharmacokinetic study. It is the first case report on the pharmacokinetic study of quassinoid glycosides so far.
METHODS AND RESULTS:
A sensitive, accurate, and repeatable UHPLC-MS/MS method was developed for the determination of bruceoside A and its major metabolite. The results showed bruceoside A could be transformed into the potent anticancer component brusatol in vivo, rather than its direct deglycosylated metabolite bruceosin. And the intestinal bacteria were proposed to take a potential role during such transformation.
CONCLUSIONS:
Based on the present study, it could be concluded that the quassinoid glycosides possessing weak activities in vitro could do contribution to the anticancer properties of Fructus Bruceae in vivo via transforming into more active metabolites.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Yadanzigan; Yadanzigan	CFN91454	76588-87-9	C₂₆H₃₈O₁₄ = 574.6	5mg	QQ客服：2159513211
鸦胆子苷C; Yadanzioside C	CFN96424	95258-16-5	C₃₄H₄₆O₁₇ = 726.72	5mg	QQ客服：2159513211
鸦胆子苷G; Yadanzioside G	CFN96422	95258-17-6	C₃₆H₄₈O₁₈ = 768.76	5mg	QQ客服：3257982914
去氢鸦胆丁; Dehydrobruceantin	CFN89337	53662-98-9	C₂₈H₃₄O₁₁ = 546.56	5mg	QQ客服：1457312923
鸦胆子苷M; Yadanzioside M	CFN96418	101559-99-3	C₃₄H₄₀O₁₆ = 704.67	5mg	QQ客服：1457312923
苦树醇B; Picrasinol B	CFN97461	89498-91-9	C₂₂H₃₂O₆ = 392.5	5mg	QQ客服：2056216494
黄苦木素B; Picrasin B	CFN98297	26121-56-2	C₂₁H₂₈O₆ = 376.5	5mg	QQ客服：2056216494
黄苦木素B乙酸酯; Picrasin B acetate	CFN98382	30315-04-9	C₂₃H₃₀O₇ = 418.5	5mg	QQ客服：2056216494
臭椿辛内酯L; Shinjulactone L	CFN92981	4283-49-2	C₂₂H₃₀O₇ = 406.47	5mg	QQ客服：3257982914
新苦木素; Neoquassine	CFN92142	76-77-7	C₂₂H₃₀O₆ = 390.5	5mg	QQ客服：2056216494

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.4648 mL	7.3239 mL	14.6477 mL	29.2954 mL	36.6193 mL
5 mM	0.293 mL	1.4648 mL	2.9295 mL	5.8591 mL	7.3239 mL
10 mM	0.1465 mL	0.7324 mL	1.4648 mL	2.9295 mL	3.6619 mL
50 mM	0.0293 mL	0.1465 mL	0.293 mL	0.5859 mL	0.7324 mL
100 mM	0.0146 mL	0.0732 mL	0.1465 mL	0.293 mL	0.3662 mL

鸦胆子苷 A

Bruceoside A

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