Info: Read More
    		•
  • 中药标准品生产商，产品定制服务
    		•
  • 首页
  • 天然产物
  • 产品文献
  • 最新产品
  • 订购流程
  • 公司新闻
  • 公司简介
  • 联系我们
  • 首页
  • /
  • 天然产物（标准品）
  • /
  • 鸦胆子素E

    • 鸦胆子素E

    Bruceine E

    鸦胆子素E
    		产品编号 CFN89340
    CAS编号 21586-90-3
    分子式 = 分子量 C20H28O9 = 412.43
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The seeds of Brucea javanica (L.) Merr.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鸦胆子素E CFN89340 21586-90-3 10mg QQ客服：2159513211
    鸦胆子素E CFN89340 21586-90-3 20mg QQ客服：2159513211
    鸦胆子素E CFN89340 21586-90-3 50mg QQ客服：2159513211
    鸦胆子素E CFN89340 21586-90-3 100mg QQ客服：2159513211
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题，请将产品存入冰霜并且样品瓶保持密封，产品可以存放长达24个月（2-8摄氏度）。

    2. 只要有可能，产品溶解后，您应该在同一天应用于您的实验。 但是，如果您需要提前做预实验，或者需要全部溶解，我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常，这些可用于长达两周。 使用前，打开样品瓶前，我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度，使用和处理的建议？ 请发送电子邮件至：service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话：
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到：027-84254680

    • 提供订购信息
  • 为了方便客户的订购，请需要订购ChemFaces产品的客户，在下单的时候请提供下列信息，以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号（CAS No.或产品名称）
  • 2. 发货地址
  • 3. 联系方法 (联系人，电话）
  • 4. 开票抬头 (如果需要发票的客户）
  • 5. 发票地址（发货地址与发票地址不同）
    • 发货时间
    1. 付款方式为100%预付款客户，我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户，我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品，需要重新生产，我们有权告知客户，交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of Eastern Finland (Finland)
  • Subang Jaya Medical Centre (Malaysia)
  • Harvard University (USA)
  • Ateneo de Manila University (Philippines)
  • Aarhus University (Denmark)
  • Universidad de Ciencias y Artes de Chiapas (Mexico)
  • University of Indonesia (Indonesia)
  • University of Ioannina (Greece)
  • Korea Institute of Oriental Medicine (Korea)
  • Indian Institute of Science (India)
  • Center for protein Engineering (CIP) (Belgium)
  • Worcester Polytechnic Institute (USA)
  • University of Hawaii Cancer Center (USA)
  • University of Melbourne (Australia)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Nat Prod Commun.2018, 10.1177
  • Int J Mol Sci.2019, 20(23):E6071
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • J Am Soc Mass Spectrom.2021, 32(5):1205-1214.
  • Molecules.2019, 24(17):E3127
  • Front Pharmacol.2021, 12:765521.
  • J Pharm Biomed Anal.2023, 234:115570.
  • Pharmacognosy Magazine2017, 13(52):868-874
  • Saudi Pharm J2020, 10.1016
  • Industrial Crops and Products2022, 188:115638
  • Int J Mol Sci.2020, 21(19),7070.
  • Turkish Journal of Pharmaceutical Sciences2022, DOI: 10.4274
  • Applied Biological Chemistry2022, 65(77).
  • Metabolites.2023, 13(5):625.
  • J Agric Food Chem.2021, 69(11):3496-3510.
  • J Agric Food Chem.2018, 66(1):351-358
  • Molecules.2021, 26(6):1635.
  • Int J Mol Sci.2021, 22(10):5181.
  • J Ginseng Res.2023, 47(4):572-582.
  • Oncotarget.2017, 8(64):108006-108019
  • Heliyon.2023, 9(12):e22932.
  • Processes2022, 10(10), 2008.
  • Biomolecules.2022, 12(12):1754.
  • ...
    • 生物活性
    Description: Bruceine E exhibits significant blood glucose concentration reduction activity, it might act as an insulin secretagogue.
    In vitro:
    Arch Pharm Res. 2011 Aug;34(8):1297-300.
    One new pregnane glycoside from the seeds of cultivated Brucea javanica.[Pubmed: 21910051]
    A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica.
    METHODS AND RESULTS:
    The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells.
    CONCLUSIONS:
    These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource.
    In vivo:
    J Ethnopharmacol. 2009 Jul 30;124(3):586-91.
    Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds.[Pubmed: 19439174 ]
    The seeds of Brucea javanica (L.) Merr (Simaroubaceae) are recommended by traditional practitioners for the treatment of diabetes mellitus. To identify the compounds responsible for blood glucose lowering effect and evaluate the acute toxicity of the compounds.
    METHODS AND RESULTS:
    Extracts, fractions and subfractions were administered to normoglycemic mice and the blood glucose concentration was monitored for 8 h. Bioactive compounds isolated through column chromatography were administered to normoglycemic mice and streptozotocin (STZ) rats with monitoring of blood glucose concentration at 0-8h. The acute toxicity was evaluated in mice. Bioactivity-guided fractionation led to the isolation of Bruceine E (1) and bruceine D (2). Normoglycemic mice administered with 1 mg/kg of 1 and 2 exhibited significant blood glucose concentration reduction of 40.07+/-11.45% and 48.82+/-13.34%, respectively. STZ induced diabetic rats administered with 1 and 2 exhibited significant blood glucose concentration reduction of 73.57+/-13.64% and 87.99+/-2.91%, respectively.
    CONCLUSIONS:
    The reduction of blood glucose concentration by both bruceines was comparable to glibenclamide and they might act as an insulin secretagogue. The presence of a hydroxyl moiety at C(2) in 1 reduced the toxic effect by 9-fold compared to 2.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4247 mL 12.1233 mL 24.2465 mL 48.4931 mL 60.6163 mL
    5 mM 0.4849 mL 2.4247 mL 4.8493 mL 9.6986 mL 12.1233 mL
    10 mM 0.2425 mL 1.2123 mL 2.4247 mL 4.8493 mL 6.0616 mL
    50 mM 0.0485 mL 0.2425 mL 0.4849 mL 0.9699 mL 1.2123 mL
    100 mM 0.0242 mL 0.1212 mL 0.2425 mL 0.4849 mL 0.6062 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    宽缨酮; Eurycomanone CFN92008 84633-29-4 C20H24O9 = 408.4 20mg QQ客服：1413575084
    13β,21-二羟基宽缨酮; 13beta,21-dihydroxyeurycomanone (Pasakbumin C) CFN95770 129587-06-0 C20H26O11 = 442.4 10mg QQ客服：2159513211
    Pasakbumin B; Pasakbumin B CFN92009 138809-10-6 C20H24O10 = 424.4 5mg QQ客服：1457312923
    鸦胆子素 D; Bruceine D CFN90771 21499-66-1 C20H26O9 = 410.4 20mg QQ客服：1457312923
    鸦胆苦内酯C; Yadanziolide C CFN96426 95258-12-1 C20H26O9 = 410.41 5mg QQ客服：215959384
    鸦胆苦内酯B; Yadanziolide B CFN96427 95258-13-2 C20H26O11 = 442.41 5mg QQ客服：1413575084
    鸦胆苦内酯A; Yadanziolide A CFN96428 95258-14-3 C20H26O10 = 426.41 10mg QQ客服：2159513211
    鸦胆子素E; Bruceine E CFN89340 21586-90-3 C20H28O9 = 412.43 20mg QQ客服：2056216494
    鸦胆子苷I; Yadanzioside I CFN96421 99132-95-3 C29H38O16 = 642.60 5mg QQ客服：2056216494
    二氢鸦胆子苷B; Yadanzioside B CFN91453 106387-01-3 C32H44O17 = 700.7 5mg QQ客服：2056216494

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用，不用于诊断或治疗程序。

    联系方式


    电机：027-84237783
    传真：027-84254680
    在线QQ: 1413575084
    E-Mail：manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家，科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产。