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  • 鸦胆子素E

    • 鸦胆子素E

    Bruceine E

    鸦胆子素E
    		产品编号 CFN89340
    CAS编号 21586-90-3
    分子式 = 分子量 C20H28O9 = 412.43
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The seeds of Brucea javanica (L.) Merr.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    鸦胆子素E CFN89340 21586-90-3 10mg QQ客服：215959384
    鸦胆子素E CFN89340 21586-90-3 20mg QQ客服：215959384
    鸦胆子素E CFN89340 21586-90-3 50mg QQ客服：215959384
    鸦胆子素E CFN89340 21586-90-3 100mg QQ客服：215959384
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • Aarhus University (Denmark)
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  • Osmania University (India)
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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Antioxidants (Basel).2023, 12(12):2131.
  • Lab Chip.2018, 18(6):971-978
  • Molecules.2021, 26(4):817.
  • Front Pharmacol.2018, 9:236
  • Chin Med.2022, 17(1):66.
  • Pharmacognosy Journal, 2021, 13(5).
  • Oncol Rep.2021, 46(1):143.
  • Front Cell Infect Microbiol.2018, 8:292
  • J Appl Toxicol.2024, jat.4615.
  • Carbohydrate Polymer Technologies & App.2021, 2:100049.
  • Heliyon.2023, 9(11):e21944.
  • Biomed Pharmacother.2021, 137:111362.
  • Biochem Biophys Res Commun.2018, 505(1):194-200
  • Molecules.2018, 23(10):E2638
  • Front Nutr.2021, 8: 687851.
  • Br J Pharmacol.2020, 10.1111
  • Int J Mol Sci.2024, 25(6):3390.
  • Toxins (Basel).2022, 14(12):824.
  • Pharmacol Rep.2018, 70(6):1195-1201
  • University of Manitoba2023, 37433.
  • Korean J of Crop Science2019, 452-458
  • Molecules.2020, 25(7):1625.
  • Nat Commun.2021, 12(1):681.
  • ...
    • 生物活性
    Description: Bruceine E exhibits significant blood glucose concentration reduction activity, it might act as an insulin secretagogue.
    In vitro:
    Arch Pharm Res. 2011 Aug;34(8):1297-300.
    One new pregnane glycoside from the seeds of cultivated Brucea javanica.[Pubmed: 21910051]
    A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica.
    METHODS AND RESULTS:
    The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells.
    CONCLUSIONS:
    These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource.
    In vivo:
    J Ethnopharmacol. 2009 Jul 30;124(3):586-91.
    Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds.[Pubmed: 19439174 ]
    The seeds of Brucea javanica (L.) Merr (Simaroubaceae) are recommended by traditional practitioners for the treatment of diabetes mellitus. To identify the compounds responsible for blood glucose lowering effect and evaluate the acute toxicity of the compounds.
    METHODS AND RESULTS:
    Extracts, fractions and subfractions were administered to normoglycemic mice and the blood glucose concentration was monitored for 8 h. Bioactive compounds isolated through column chromatography were administered to normoglycemic mice and streptozotocin (STZ) rats with monitoring of blood glucose concentration at 0-8h. The acute toxicity was evaluated in mice. Bioactivity-guided fractionation led to the isolation of Bruceine E (1) and bruceine D (2). Normoglycemic mice administered with 1 mg/kg of 1 and 2 exhibited significant blood glucose concentration reduction of 40.07+/-11.45% and 48.82+/-13.34%, respectively. STZ induced diabetic rats administered with 1 and 2 exhibited significant blood glucose concentration reduction of 73.57+/-13.64% and 87.99+/-2.91%, respectively.
    CONCLUSIONS:
    The reduction of blood glucose concentration by both bruceines was comparable to glibenclamide and they might act as an insulin secretagogue. The presence of a hydroxyl moiety at C(2) in 1 reduced the toxic effect by 9-fold compared to 2.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.4247 mL 12.1233 mL 24.2465 mL 48.4931 mL 60.6163 mL
    5 mM 0.4849 mL 2.4247 mL 4.8493 mL 9.6986 mL 12.1233 mL
    10 mM 0.2425 mL 1.2123 mL 2.4247 mL 4.8493 mL 6.0616 mL
    50 mM 0.0485 mL 0.2425 mL 0.4849 mL 0.9699 mL 1.2123 mL
    100 mM 0.0242 mL 0.1212 mL 0.2425 mL 0.4849 mL 0.6062 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    鸦胆子苦醇; Brusatol CFN93119 14907-98-3 C26H32O11 = 520.53 20mg QQ客服：2159513211
    鸦胆亭; Bruceantin CFN89339 41451-75-6 C28H36O11 = 548.57 5mg QQ客服：3257982914
    鸦胆子酸C; Bruceanic acid C CFN91975 132587-60-1 C29H38O14 = 610.60 5mg QQ客服：3257982914
    臭椿酮; Ailanthone CFN97561 981-15-7 C20H24O7 = 376.4 20mg QQ客服：2056216494
    Etuycomanol; Etuycomanol CFN95771 84633-28-3 C20H26O9 = 410.4 10mg QQ客服：215959384
    宽缨酮; Eurycomanone CFN92008 84633-29-4 C20H24O9 = 408.4 20mg QQ客服：3257982914
    13β,21-二羟基宽缨酮; 13beta,21-dihydroxyeurycomanone (Pasakbumin C) CFN95770 129587-06-0 C20H26O11 = 442.4 10mg QQ客服：3257982914
    Pasakbumin B; Pasakbumin B CFN92009 138809-10-6 C20H24O10 = 424.4 5mg QQ客服：2056216494
    鸦胆子素 D; Bruceine D CFN90771 21499-66-1 C20H26O9 = 410.4 20mg QQ客服：3257982914
    鸦胆苦内酯C; Yadanziolide C CFN96426 95258-12-1 C20H26O9 = 410.41 5mg QQ客服：3257982914

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