鸦胆子素E

Bruceine E

	产品编号	CFN89340
	CAS编号	21586-90-3
	分子式 = 分子量	C₂₀H₂₈O₉ = 412.43
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The seeds of Brucea javanica (L.) Merr.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
鸦胆子素E	CFN89340	21586-90-3	10mg	QQ客服：215959384
鸦胆子素E	CFN89340	21586-90-3	20mg	QQ客服：215959384
鸦胆子素E	CFN89340	21586-90-3	50mg	QQ客服：215959384
鸦胆子素E	CFN89340	21586-90-3	100mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Monash University Sunway Campus (Malaysia)

Osmania University (India)

Universite Libre de Bruxelles (Belgium)

Gyeongsang National University (Korea)

Center for protein Engineering (CIP) (Belgium)

Charles Sturt University (Denmark)

Aveiro University (Portugal)

University of Toronto (Canada)

Chiang Mai University (Thailand)

University of Madras (India)

Universidad de Ciencias y Artes de Chiapas (Mexico)

University of Wuerzburg (Germany)

Instituto de Investigaciones Agropecuarias (Chile)

Harvard University (USA)

More...

Description:

Bruceine E exhibits significant blood glucose concentration reduction activity, it might act as an insulin secretagogue.

In vitro:

Arch Pharm Res. 2011 Aug;34(8):1297-300.

One new pregnane glycoside from the seeds of cultivated Brucea javanica.[Pubmed: 21910051]

A new pregnane glycoside, named (20R)-O-(3)-β-D-glucopyranosyl-(1→2)-α-L-arabinopyranosyl-pregn-5-en-3β,20-diol (1), and seven known compounds, brusatol (2), bruceine B (3), bruceine D (4), yadanziolide A (5), bruceine E (6), yadanzioside G (7), and yadanzioside B (8), were isolated from the cultivated dry seeds of Brucea javanica.
METHODS AND RESULTS:
The structure of 1 was elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses. Their inhibitory effects on tumor cells were also tested. Compound 1 was slightly active against HL-60, SMMC-7721, A-549, and MCF-7 tumor cells. Compounds 2 and 3 demonstrated significant inhibitory activities against all tested cells.
CONCLUSIONS:
These results indicate that cultivated B. javanica could replace the wild plant as an antitumor plant resource.

In vivo:

J Ethnopharmacol. 2009 Jul 30;124(3):586-91.

Hypoglycemic effect of quassinoids from Brucea javanica (L.) Merr (Simaroubaceae) seeds.[Pubmed: 19439174 ]

The seeds of Brucea javanica (L.) Merr (Simaroubaceae) are recommended by traditional practitioners for the treatment of diabetes mellitus. To identify the compounds responsible for blood glucose lowering effect and evaluate the acute toxicity of the compounds.
METHODS AND RESULTS:
Extracts, fractions and subfractions were administered to normoglycemic mice and the blood glucose concentration was monitored for 8 h. Bioactive compounds isolated through column chromatography were administered to normoglycemic mice and streptozotocin (STZ) rats with monitoring of blood glucose concentration at 0-8h. The acute toxicity was evaluated in mice. Bioactivity-guided fractionation led to the isolation of Bruceine E (1) and bruceine D (2). Normoglycemic mice administered with 1 mg/kg of 1 and 2 exhibited significant blood glucose concentration reduction of 40.07+/-11.45% and 48.82+/-13.34%, respectively. STZ induced diabetic rats administered with 1 and 2 exhibited significant blood glucose concentration reduction of 73.57+/-13.64% and 87.99+/-2.91%, respectively.
CONCLUSIONS:
The reduction of blood glucose concentration by both bruceines was comparable to glibenclamide and they might act as an insulin secretagogue. The presence of a hydroxyl moiety at C(2) in 1 reduced the toxic effect by 9-fold compared to 2.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
鸦胆子素E; Bruceine E	CFN89340	21586-90-3	C₂₀H₂₈O₉ = 412.43	20mg	QQ客服：2159513211
鸦胆子苷I; Yadanzioside I	CFN96421	99132-95-3	C₂₉H₃₈O₁₆ = 642.60	5mg	QQ客服：1413575084
二氢鸦胆子苷B; Yadanzioside B	CFN91453	106387-01-3	C₃₂H₄₄O₁₇ = 700.7	5mg	QQ客服：2056216494
鸦胆子苷P; Yadanzioside P	CFN96417	79439-84-2	C₃₄H₄₆O₁₆ = 710.72	5mg	QQ客服：2159513211
鸦胆子苷L ; Yadanzioside L	CFN96419	99132-97-5	C₃₄H₄₆O₁₇ = 726.72	5mg	QQ客服：215959384
鸦胆子苷K; Yadanzioside K	CFN96420	101559-98-2	C₃₆H₄₈O₁₈ = 768.76	5mg	QQ客服：3257982914
13,18-二氢乐园树酮; 13,18-Dehydroglaucarubinone	CFN92980	68703-94-6	C₂₅H₃₂O₁₀ = 492.52	5mg	QQ客服：1457312923
(+)-乐园树酮; (+)-Glaucarubinone	CFN92979	1259-86-5	C₂₅H₃₄O₁₀ = 494.53	5mg	QQ客服：2056216494
鸦胆子素B; Bruceine B	CFN89335	25514-29-8	C₂₃H₂₈O₁₁ = 480.46	5mg	QQ客服：2056216494
鸦胆子素C; Bruceine C	CFN91974	25514-30-1	C₂₈H₃₆O₁₂ = 564.58	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4247 mL	12.1233 mL	24.2465 mL	48.4931 mL	60.6163 mL
5 mM	0.4849 mL	2.4247 mL	4.8493 mL	9.6986 mL	12.1233 mL
10 mM	0.2425 mL	1.2123 mL	2.4247 mL	4.8493 mL	6.0616 mL
50 mM	0.0485 mL	0.2425 mL	0.4849 mL	0.9699 mL	1.2123 mL
100 mM	0.0242 mL	0.1212 mL	0.2425 mL	0.4849 mL	0.6062 mL