| In vitro: |
| Chinese Traditional & Herbal Drugs,2014 ,45 (6):755-759 | | Chemical constituents from Toona ciliata var.henryi and their anti-inflammatory activities[Reference: WebLink] | To study the chemical constituents from Toona ciliata var.henryi and their bioactivities.
METHODS AND RESULTS:
Column chromatography on silica gel,RP-C18,and Sephadex LH-20 columns was used to separate and purify the chemical constituents.The structures were elucidated by physicochemical properties and spectroscopic analyses.These compounds were isolated and evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells. Fifteen compounds were isolated from the stem barks of T.ciliata var.henryi and identified as odoratone(1),toonaciliatin F(2),toonaciliatin G(3),toonaciliatin J(4),hispidone(5),Bourjotinolone A(6),3-episapeline A(7),piscidinol A(8),aglaiodiol(9),toonaciliatin M(10),2α,19-dihydroxy-9-epi-ent-pimara-7,15-diene(11),cleomiscosin B(12),cleomiscosin C(13),β-sitosterol(14),and β-daucositerol(15).The IC50 values of compounds 4 and 10 were(11.0 ± 0.7) and(28.8 ± 2.7) μmol/L.
CONCLUSIONS:
All the compounds are isolated from this plant for the first time.Compounds 11—13 are yielded from the plants of Toona Roem.for the first time.Compounds 4 and 10 show the moderate inhibitory activities. |
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