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  • 双穿心莲内酯 A

    • 双穿心莲内酯 A

    Bisandrographolide A

    双穿心莲内酯 A
    		产品编号 CFN97814
    CAS编号 160498-00-0
    分子式 = 分子量 C40H56O8 = 664.88
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Diterpenoids
    植物来源 The herbs of Andrographis paniculata (Burm. f.) Nees
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    双穿心莲内酯 A CFN97814 160498-00-0 1mg QQ客服：1457312923
    双穿心莲内酯 A CFN97814 160498-00-0 5mg QQ客服：1457312923
    双穿心莲内酯 A CFN97814 160498-00-0 10mg QQ客服：1457312923
    双穿心莲内酯 A CFN97814 160498-00-0 20mg QQ客服：1457312923
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    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

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  • ...
    • 生物活性
    Description: Bisandrographolide A activates TRPV4 channels, could play a role in some of the effects of Andrographis extract described in traditional medicine.
    Targets: TRPV
    In vitro:
    J Biol Chem. 2006 Oct 6;281(40):29897-904.
    Bisandrographolide from Andrographis paniculata activates TRPV4 channels.[Pubmed: 16899456]
    Many transient receptor potential (TRP) channels are activated or blocked by various compounds found in plants; two prominent examples include the activation of TRPV1 channels by capsaicin and the activation of TRPM8 channels by menthol.
    METHODS AND RESULTS:
    We sought to identify additional plant compounds that are active on other types of TRP channels. We screened a library of extracts from 50 Chinese herbal plants using a calcium-imaging assay to find compounds active on TRPV3 and TRPV4 channels. An extract from the plant Andrographis paniculata potently activated TRPV4 channels. The extract was fractionated further, and the active compound was identified as Bisandrographolide A (BAA). We used purified compound to characterize the activity of Bisandrographolide A on certain TRPV channel subtypes. Although Bisandrographolide A activated TRPV4 channels with an EC(50) of 790-950 nm, it did not activate or block activation of TRPV1, TRPV2, or TRPV3 channels. Bisandrographolide A activated a large TRPV4-like current in immortalized mouse keratinocytes (308 cells) that have been shown to express TRPV4 protein endogenously. This compound also activated TRPV4 currents in cell-free outside-out patches from HEK293T cells overexpressing TRPV4 cDNA, suggesting that Bisandrographolide A can activate the channel in a membrane-delimited manner. Another related compound, andrographolide, found in abundance in the plant Andrographis was unable to activate or block activation of TRPV4 channels.
    CONCLUSIONS:
    These experiments show that Bisandrographolide A activates TRPV4 channels, and we discuss the possibility that activation of TRPV4 by Bisandrographolide A could play a role in some of the effects of Andrographis extract described in traditional medicine.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.504 mL 7.5202 mL 15.0403 mL 30.0806 mL 37.6008 mL
    5 mM 0.3008 mL 1.504 mL 3.0081 mL 6.0161 mL 7.5202 mL
    10 mM 0.1504 mL 0.752 mL 1.504 mL 3.0081 mL 3.7601 mL
    50 mM 0.0301 mL 0.1504 mL 0.3008 mL 0.6016 mL 0.752 mL
    100 mM 0.015 mL 0.0752 mL 0.1504 mL 0.3008 mL 0.376 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    新穿心莲内酯; Neoandrographolide CFN97766 27215-14-1 C26H40O8 = 480.60 20mg QQ客服：2056216494
    Andropanoside; Andropanoside CFN97671 82209-72-1 C26H40O9 = 496.60 5mg QQ客服：2056216494
    14-脱氧-11,12-二脱氢穿心莲内酯苷; 14-Deoxy-11,12-didehydroandrographiside CFN97822 141973-41-3 C26H38O9 = 494.58 5mg QQ客服：1413575084
    穿心莲内酯苷; Andrographiside CFN97670 82209-76-5 C26H40O10 = 512.60 5mg QQ客服：1413575084
    双穿心莲内酯 C; Bisandrographolide C CFN97813 160498-02-2 C40H56O8 = 664.88 5mg QQ客服：3257982914
    双穿心莲内酯 A; Bisandrographolide A CFN97814 160498-00-0 C40H56O8 = 664.88 5mg QQ客服：1413575084

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