双穿心莲内酯 A

Bisandrographolide A

	产品编号	CFN97814
	CAS编号	160498-00-0
	分子式 = 分子量	C₄₀H₅₆O₈ = 664.88
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Diterpenoids
	植物来源	The herbs of Andrographis paniculata (Burm. f.) Nees
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产品名称	产品编号	CAS编号	包装	QQ客服
双穿心莲内酯 A	CFN97814	160498-00-0	1mg	QQ客服：2159513211
双穿心莲内酯 A	CFN97814	160498-00-0	5mg	QQ客服：2159513211
双穿心莲内酯 A	CFN97814	160498-00-0	10mg	QQ客服：2159513211
双穿心莲内酯 A	CFN97814	160498-00-0	20mg	QQ客服：2159513211

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National Research Council of Canada (Canada)

Institute of Tropical Disease Universitas Airlangga (Indonesia)

Cancer Research Initatives Foundation(CARIF) (Malaysia)

Chungnam National University (Korea)

Rio de Janeiro State University (Brazil)

Universidad Veracuzana (Mexico)

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Ain Shams University (Egypt)

Mahidol University (Thailand)

Instytut Nawozów Sztucznych w Pu?awach (Poland)

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Description:

Bisandrographolide A activates TRPV4 channels, could play a role in some of the effects of Andrographis extract described in traditional medicine.

Targets:

TRPV

In vitro:

J Biol Chem. 2006 Oct 6;281(40):29897-904.

Bisandrographolide from Andrographis paniculata activates TRPV4 channels.[Pubmed: 16899456]

Many transient receptor potential (TRP) channels are activated or blocked by various compounds found in plants; two prominent examples include the activation of TRPV1 channels by capsaicin and the activation of TRPM8 channels by menthol.
METHODS AND RESULTS:
We sought to identify additional plant compounds that are active on other types of TRP channels. We screened a library of extracts from 50 Chinese herbal plants using a calcium-imaging assay to find compounds active on TRPV3 and TRPV4 channels. An extract from the plant Andrographis paniculata potently activated TRPV4 channels. The extract was fractionated further, and the active compound was identified as Bisandrographolide A (BAA). We used purified compound to characterize the activity of Bisandrographolide A on certain TRPV channel subtypes. Although Bisandrographolide A activated TRPV4 channels with an EC(50) of 790-950 nm, it did not activate or block activation of TRPV1, TRPV2, or TRPV3 channels. Bisandrographolide A activated a large TRPV4-like current in immortalized mouse keratinocytes (308 cells) that have been shown to express TRPV4 protein endogenously. This compound also activated TRPV4 currents in cell-free outside-out patches from HEK293T cells overexpressing TRPV4 cDNA, suggesting that Bisandrographolide A can activate the channel in a membrane-delimited manner. Another related compound, andrographolide, found in abundance in the plant Andrographis was unable to activate or block activation of TRPV4 channels.
CONCLUSIONS:
These experiments show that Bisandrographolide A activates TRPV4 channels, and we discuss the possibility that activation of TRPV4 by Bisandrographolide A could play a role in some of the effects of Andrographis extract described in traditional medicine.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
新穿心莲内酯; Neoandrographolide	CFN97766	27215-14-1	C₂₆H₄₀O₈ = 480.60	20mg	QQ客服：2056216494
Andropanoside; Andropanoside	CFN97671	82209-72-1	C₂₆H₄₀O₉ = 496.60	5mg	QQ客服：3257982914
14-脱氧-11,12-二脱氢穿心莲内酯苷; 14-Deoxy-11,12-didehydroandrographiside	CFN97822	141973-41-3	C₂₆H₃₈O₉ = 494.58	5mg	QQ客服：1457312923
穿心莲内酯苷; Andrographiside	CFN97670	82209-76-5	C₂₆H₄₀O₁₀ = 512.60	5mg	QQ客服：2159513211
双穿心莲内酯 C; Bisandrographolide C	CFN97813	160498-02-2	C₄₀H₅₆O₈ = 664.88	5mg	QQ客服：215959384
双穿心莲内酯 A; Bisandrographolide A	CFN97814	160498-00-0	C₄₀H₅₆O₈ = 664.88	5mg	QQ客服：1413575084

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.504 mL	7.5202 mL	15.0403 mL	30.0806 mL	37.6008 mL
5 mM	0.3008 mL	1.504 mL	3.0081 mL	6.0161 mL	7.5202 mL
10 mM	0.1504 mL	0.752 mL	1.504 mL	3.0081 mL	3.7601 mL
50 mM	0.0301 mL	0.1504 mL	0.3008 mL	0.6016 mL	0.752 mL
100 mM	0.015 mL	0.0752 mL	0.1504 mL	0.3008 mL	0.376 mL