甜没药姜黄醇

Bisacurone

	产品编号	CFN96432
	CAS编号	120681-81-4
	分子式 = 分子量	C₁₅H₂₄O₃ = 252.35
	产品纯度	>=98%
	物理属性	Oil
	化合物类型	Sesquiterpenoids
	植物来源	The rhizomes of Curcuma longa.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
甜没药姜黄醇	CFN96432	120681-81-4	10mg	QQ客服：2056216494
甜没药姜黄醇	CFN96432	120681-81-4	20mg	QQ客服：2056216494
甜没药姜黄醇	CFN96432	120681-81-4	50mg	QQ客服：2056216494
甜没药姜黄醇	CFN96432	120681-81-4	100mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Description:

Bisacurone has anti-oxidant, anti-inflammatory, and anti-metastatic activities, it may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidation and inflammation.

Targets:

TNF-α | IL Receptor | ROS | p65 | NF-kB | Akt | PKC | IkB | IKK

In vitro:

Int Immunopharmacol. 2008 Sep;8(9):1272-81.

Bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of VCAM-1 expression.[Pubmed: 18602074 ]

Bisacurone, one of the active compounds of the traditionally used indigenous herb Curcuma longa Linne (Zingiberaceae), has anti-oxidant, anti-inflammatory, and anti-metastatic activities.
METHODS AND RESULTS:
We studied how the level of vascular cell adhesion molecule-1 (VCAM-1), one of the key molecules in the development of atherosclerosis as well as carcinogenesis and metastasis, might be affected by Bisacurone in tumor necrosis factor-alpha (TNF-alpha)-activated human umbilical vein endothelial cells (HUVECs). Bisacurone dose-dependently inhibited TNF-alpha-mediated expression of VCAM-1. It showed significant suppressive effect on ROS generation in response to TNF-alpha stimulation and it blocked nuclear factor-kappa B (NF-kappaB) p65 translocation into the nucleus and phosphorylation of inhibitory factor kappaBalpha (IkappaBalpha). It also inhibited phosphorylation of Akt and PKC, which are upstream in the regulation of VCAM-1 by TNF-alpha. Furthermore, Bisacurone decreased U937 monocyte and human oral cancer cell (Hep-2, QLL-I, SCC-15) adhesion to HUVECs stimulated by TNF-alpha, suggesting that it may inhibit the binding of these cells by regulating the expression of critical adhesion molecules by TNF-alpha.
CONCLUSIONS:
Thus, Bisacurone may be beneficial in the treatment of inflammatory diseases, such as atherosclerosis, where inflammatory monocytes are involved in their pathology, and, moreover, in the development of tumors.

In vivo:

J Nutr Sci. 2017 Jan 12;6:e3.

A hot water extract of turmeric (Curcuma longa) suppresses acute ethanol-induced liver injury in mice by inhibiting hepatic oxidative stress and inflammatory cytokine production.[Pubmed: 28620478 ]

Turmeric (Curcuma longa) is a widely used spice that has various biological effects, and aqueous extracts of turmeric exhibit potent antioxidant activity and anti-inflammatory activity. Bisacurone, a component of turmeric extract, is known to have similar effects. Oxidative stress and inflammatory cytokines play an important role in ethanol-induced liver injury.
METHODS AND RESULTS:
This study was performed to evaluate the influence of a hot water extract of C. longa (WEC) or Bisacurone on acute ethanol-induced liver injury. C57BL/6 mice were orally administered WEC (20 mg/kg body weight; BW) or Bisacurone (60 μg/kg BW) at 30 min before a single dose of ethanol was given by oral administration (3·0 g/kg BW). The increase of alanine aminotransferase was also significantly suppressed by pretreatment with Bisacurone. Compared with control mice, animals given WEC had higher hepatic tissue levels of superoxide dismutase and glutathione, as well as lower hepatic tissue levels of thiobarbituric acid-reactive substances, TNF-α protein and IL-6 mRNA.
CONCLUSIONS:
These results suggest that oral administration of WEC may have a protective effect against ethanol-induced liver injury by suppressing hepatic oxidation and inflammation, at least partly through the effects of Bisacurone.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
9-氧代-2,7-甜没药二烯-15-酸; 9-Oxo-2,7-bisaboladien-15-oic acid	CFN97512	93888-59-6	C₁₅H₂₂O₃ = 250.3	5mg	QQ客服：2056216494
4-羟基-4-甲基-2-((1R)-1-异丙基-4-氧代戊基)-2-环己烯-1-酮; 4-Hydroxy-1,10-secocadin-5-ene-1,10-dione	CFN96371	226904-40-1	C₁₅H₂₄O₃ = 252.4	5mg	QQ客服：2056216494
没药当归烯酮; Bisabolangelone	CFN91876	30557-81-4	C₁₅H₂₀O₃ = 248.32	10mg	QQ客服：1457312923
3,4-Seco-3-oxobisabol-10-ene-4,1-olide; 3,4-Seco-3-oxobisabol-10-ene-4,1-olide	CFN89267	1564265-85-5	C₁₅H₂₄O₃ = 252.35	5mg	QQ客服：3257982914
梓木内酯; Catalpalactone	CFN99670	1585-68-8	C₁₅H₁₄O₄ = 258.3	5mg	QQ客服：3257982914
梣酮; Fraxinellone	CFN99782	28808-62-0	C₁₄H₁₆O₃ = 232.28	20mg	QQ客服：1413575084
9beta-羟基梣酮; Dasycarpol	CFN96832	202343-57-5	C₁₄H₁₆O₄ = 248.27	5mg	QQ客服：2159513211
6-甲氧基梣酮; 6-Methoxyfraxinellone	CFN95485	N/A	C₁₅H₁₈O₄ = 262.3	10mg	QQ客服：2159513211
韧革菌素K; Vibralactone K	CFN96453	1623786-66-2	C₁₂H₁₈O₃ = 210.27	5mg	QQ客服：1413575084
韧革菌素B; Vibralactone B	CFN96455	1093230-95-5	C₁₂H₁₆O₄ = 224.26	5mg	QQ客服：215959384

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.9628 mL	19.8138 mL	39.6275 mL	79.255 mL	99.0688 mL
5 mM	0.7926 mL	3.9628 mL	7.9255 mL	15.851 mL	19.8138 mL
10 mM	0.3963 mL	1.9814 mL	3.9628 mL	7.9255 mL	9.9069 mL
50 mM	0.0793 mL	0.3963 mL	0.7926 mL	1.5851 mL	1.9814 mL
100 mM	0.0396 mL	0.1981 mL	0.3963 mL	0.7926 mL	0.9907 mL

甜没药姜黄醇

Bisacurone

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