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  • 韧革菌素B

    • 韧革菌素B

    Vibralactone B

    韧革菌素B
    		产品编号 CFN96455
    CAS编号 1093230-95-5
    分子式 = 分子量 C12H16O4 = 224.26
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Sesquiterpenoids
    植物来源 From the cultures of the Basidiomycete Boreostereum vibrans.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    韧革菌素B CFN96455 1093230-95-5 1mg QQ客服：2056216494
    韧革菌素B CFN96455 1093230-95-5 5mg QQ客服：2056216494
    韧革菌素B CFN96455 1093230-95-5 10mg QQ客服：2056216494
    韧革菌素B CFN96455 1093230-95-5 20mg QQ客服：2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
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    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

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    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Kor. J. Herbol.2019, 34(2):59-66
  • Preprints2017, 2017120176
  • Toxins (Basel).2021, 13(9):593.
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  • Molecules. 2013, 18(11):14105-21
  • Mol Microbiol.2019, 112(1):317-332
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  • Molecules.2018, 23(7):E1817
  • Molecules.2020, 25(18),4089.
  • Hindawi J of Food Biochemistry2023, P17:8883860
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  • Int J Mol Sci.2021, 22(19):10405.
  • J Pharm Biomed Anal2016, 118:183-194
  • Evid Based Complement Alternat Med.2020, 2020:8582318.
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  • Mol Cells.2018, 41(8):771-780
  • J Microbiol Immunol Infect.2021, S1684-1182(21)00142-0.
  • J Ethnopharmacol.2019, 241:112025
  • Journal of Ginseng Research2022, j.jgr.2022.09.005.
  • Int J Mol Sci.2017, 19(1)
  • ...
    • 生物活性
    Description: Vibralactone B shows antibacterial activity, it can inhibit significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 ug/mL, respectively.
    Targets: Antifection
    In vitro:
    Food Chem Toxicol. 2017 May 18. pii: S0278-6915(17)30264-8.
    Antifungal activities of secondary metabolites isolated from liquid fermentations of Stereum hirsutum (Sh134-11) against Botrytis cinerea (grey mould agent).[Pubmed: 28528973]

    METHODS AND RESULTS:
    Extracts obtained from liquid mycelial fermentations of the Chilean fungus Stereum hirsutum (Sh134-11) showed antifungal activity against Botrytis cinerea. Two types of extracts were obtained: EtOAc-extract (liquid phase) and MeOH-extract (mycelial phase). Plate diffusion assay showed that EtOAc-extracts were more active than MeOH-extracts. A large-scale fermentation of Sh134-11 and chromatographic methods allowed to isolated four compounds: MS-3, Vibralactone, Vibralactone B and Sterenin D. Only Sterenin D showed antifungal activity against B. cinerea in the tests performed. Effects on the mycelial growth of B. cinerea showed that Sterenin D showed inhibition at 1000-2000 μg/mL reaching 67% and 76% respectively. Sterenin D was more effective to control the sporogenesis, inhibiting in 96% the sporulation at 500 μg/mL. Assays showed that Sterenin D exhibited a minimal fungicidal concentration (MFC) of 50 μg/mL and minimal inhibitory concentration (MIC) at 20 μg/mL.
    CONCLUSIONS:
    Our study indicated that submerged fermentations of Chilean S. hirsutum (Sh134-11) produced extracts with antifungal activity and Sterenin D is responsible for this activity, which could be used as possible biofungicides alternative to synthetic fungicides.
    Z Naturforsch C. 2015;70(3-4):97-102.
    Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale.[Pubmed: 26020559 ]

    METHODS AND RESULTS:
    Liquid fermentations of the fungus Stereum rameale (N° 2511) yielded extracts with antibacterial activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration.
    CONCLUSIONS:
    Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 μg/mL), Bacillus subtilis (10 μg/mL) and Staphylococcus aureus (100 μg/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 μg/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 μg/mL, respectively.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.4591 mL 22.2955 mL 44.5911 mL 89.1822 mL 111.4777 mL
    5 mM 0.8918 mL 4.4591 mL 8.9182 mL 17.8364 mL 22.2955 mL
    10 mM 0.4459 mL 2.2296 mL 4.4591 mL 8.9182 mL 11.1478 mL
    50 mM 0.0892 mL 0.4459 mL 0.8918 mL 1.7836 mL 2.2296 mL
    100 mM 0.0446 mL 0.223 mL 0.4459 mL 0.8918 mL 1.1148 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    2-Methyl-6-(p-tolyl)heptane-2,3-diol; 2-Methyl-6-(p-tolyl)heptane-2,3-diol CFN96946 117421-22-4 C15H24O2 = 236.35 5mg QQ客服：2159513211
    芳姜黄酮; ar-Turmerone CFN89231 532-65-0 C15H20O = 216.32 20mg QQ客服：2056216494
    11-羟基甜没药-1,3,5-三烯-9-酮; 11-Hydroxybisabola-1,3,5-trien-9-one CFN89247 61235-23-2 C15H22O2 = 234.33 5mg QQ客服：3257982914
    8-Hydroxy-ar-turmerone; 8-Hydroxy-ar-turmerone CFN89227 949081-09-8 C15H20O2 = 232.32 5mg QQ客服：215959384
    6-(4-Hydroxy-3-methylphenyl)-2-methylhept-2-en-4-one; 6-(4-Hydroxy-3-methylphenyl)-2-methylhept-2-en-4-one CFN89228 949081-05-4 C15H20O2 = 232.32 10mg QQ客服：215959384
    Intermedin B ; Intermedin B CFN89016 127214-87-3 C15H22O2 = 234.33 20mg QQ客服：1457312923
    甜没药姜黄醇; Bisacurone CFN96432 120681-81-4 C15H24O3 = 252.35 20mg QQ客服：1413575084
    Bisacurone C; Bisacurone C CFN89015 127214-86-2 C15H24O3 = 252.35 5mg QQ客服：1413575084
    3-羟基甜没药-1,10-二烯-9-酮; 3-Hydroxybisabola-1,10-dien-9-one CFN89024 129673-86-5 C15H24O2 = 236.35 5mg QQ客服：2159513211
    3,4-二羟基甜没药-1,10-二烯; 3,4-Dihydroxybisabola-1,10-diene CFN89025 129673-87-6 C15H26O2 = 238.37 5mg QQ客服：3257982914

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