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  • 佛手苷内酯

    Bergapten

    佛手苷内酯
    产品编号 CFN98766
    CAS编号 484-20-8
    分子式 = 分子量 C12H8O4 = 216.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Coumarins
    植物来源 The roots of Angelica dahurica.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    佛手苷内酯 CFN98766 484-20-8 10mg QQ客服:2056216494
    佛手苷内酯 CFN98766 484-20-8 20mg QQ客服:2056216494
    佛手苷内酯 CFN98766 484-20-8 50mg QQ客服:2056216494
    佛手苷内酯 CFN98766 484-20-8 100mg QQ客服:2056216494
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    IF=12.804(2019)

    PMID: 30417089
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Vietnam J. Chem.2023, 61(3),308-317
  • Elife.2021, 10:e68058.
  • J AOAC Int.2023, 106(1):56-64.
  • Horticulturae2020, 6(4),76.
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  • Front Pharmacol.2021, 12:764297.
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  • Evid Based Complement Alternat Med.2021, 2021:5585692.
  • Cells.2022, 11(8), 1311.
  • Pharmaceutics.2020, 12(9):845.
  • Appl. Sci.2022, 12(17), 8646.
  • FEBS Lett.2021, 595(20):2608-2615.
  • Nutrients.2020, 12(11):3448.
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  • ...
  • 生物活性
    Description: Bergapten is a psoralen that can be photoactivated and is capable of crossing-linking DNA, covalently modifying proteins and lipids, and consequently inhibiting cell replication. Bergapten has anti-inflammatory and anti-tumor agent, it exhibits significant inhibition of the production of pro-inflammatory cytokines, namely tumour necrotic factor-α(TNF-α) and interleukin-6 (IL-6) by peripheral blood mononuclear cells (PBMCs) stimulated with lipopolysaccharide in a concentration-dependent manner. Bergapten effectively prevents LPS-induced osteoclastogenesis, bone resorption and survival via apoptotic response of osteoclasts and their precursors.
    Targets: TGF-β/Smad | Caspase | TNF-α | IL Receptor | PI3K | p53 | Akt | p21
    In vitro:
    Int Orthop. 2014 Mar;38(3):627-34.
    Bergapten prevents lipopolysaccharide mediated osteoclast formation, bone resorption and osteoclast survival.[Pubmed: 24305787]

    METHODS AND RESULTS:
    To investigate the effect of Bergapten on osteoclastic bone resorption, RAW264.7 cells were treated with Bergapten for six days in the presence of LPS, and the area of bone resorption was analyzed with Image Pro-Plus. Next, we examined apoptosis of RAW264.7 cells after Bergapten incubation for 48 hours by flow cytometer using annexin V/propidium iodide (PI) double labeling. Finally, osteoclast survival was observed by Hoechst 33342 labeling and Western blotting after Bergapten treatment for 24 hours. RESULTS: Data showed that Bergapten (5-40 μmol/L) dose-dependently inhibited LPS-induced osteoclast formation and bone resorption. Treatment with Bergapten triggered apoptotic death of osteoclast precursor RAW264.7 cells in a dose-dependent manner. Furthermore, Bergapten significantly reduced the survival of mature osteoclast, as demonstrated by emergence of apoptotic nuclei and activation of apoptotic protein caspase 3/9.
    CONCLUSIONS:
    These findings suggest that Bergapten effectively prevents LPS-induced osteoclastogenesis, bone resorption and survival via apoptotic response of osteoclasts and their precursors. The study identifies Bergapten as an inhibitor of osteoclast formation and bone resorption and provides evidence that Bergapten might be beneficial as an alternative for prevention and treatment of inflammatory bone loss.
    Nat Prod Res. 2011 Sep;25(15):1444-9.
    Effect of bergapten from Heracleum nepalense root on production of proinflammatory cytokines.[Pubmed: 19662568]
    In the present investigation, the anti-inflammatory activity of isolated bergapten from hydroalcoholic extract of Heracleum nepalense root was evaluated in vitro using human peripheral blood mononuclear cells (PBMCs).
    METHODS AND RESULTS:
    Bergapten exhibited significant inhibition of the production of pro-inflammatory cytokines, namely tumour necrotic factor-α (TNF-α) and interleukin-6 (IL-6) by PBMCs stimulated with lipopolysaccharide in a concentration-dependent manner.
    In vivo:
    J Am Acad Dermatol. 1988 Feb;18(2 Pt 1):333-8.
    5-Methoxypsoralen (Bergapten) for photochemotherapy. Bioavailability, phototoxicity, and clinical efficacy in psoriasis of a new drug preparation.[Pubmed: 3279089]
    In a previous study we evaluated a microcrystalline preparation of 5-methoxypsoralen (5-MOP; Bergapten) for its photochemotherapeutic properties. Preliminary data indicated that the clinical efficacy of 5-MOP is comparable to that of 8-methoxypsoralen. 5-MOP appeared as a promising alternative photosensitizer for the management of psoriasis because of the almost complete lack of phototoxic and drug intolerance reactions that are frequently encountered in patients undergoing 8-MOP photochemotherapy.
    METHODS AND RESULTS:
    With a new liquid preparation of 5-MOP we have now extended our earlier investigation on a larger clinical scale and have correlated the clinical response with the bioavailability of the drug. Serum level determinations showed an absorption rate of only approximately 25% that of 8-MOP. When administered in the same dosage as 8-MOP, 5-MOP turned out to be significantly less effective; however, by doubling the oral dosage, comparable results in terms of clearing of psoriasis were obtained. Also with this high-dose 5-MOP regimen, no drug intolerance was noted and other side effects, such as severe erythema, pruritus, and nausea, occurred only rarely.
    CONCLUSIONS:
    We propose 5-MOP as a valuable alternative for photochemotherapy (PUVA) of PUVA-responsive diseases.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.6253 mL 23.1267 mL 46.2535 mL 92.5069 mL 115.6337 mL
    5 mM 0.9251 mL 4.6253 mL 9.2507 mL 18.5014 mL 23.1267 mL
    10 mM 0.4625 mL 2.3127 mL 4.6253 mL 9.2507 mL 11.5634 mL
    50 mM 0.0925 mL 0.4625 mL 0.9251 mL 1.8501 mL 2.3127 mL
    100 mM 0.0463 mL 0.2313 mL 0.4625 mL 0.9251 mL 1.1563 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    花椒毒素; 8-甲氧基补骨脂素; Xanthotoxin CFN98372 298-81-7 C12H8O4 = 216.2 20mg QQ客服:2056216494
    佛手酚葡萄糖苷; Bergaptol-beta-glucopyranoside CFN95186 131623-13-7 C17H16O9 = 364.3 10mg QQ客服:3257982914
    8-羟基-5-O-beta-D-吡喃葡萄糖补骨脂素; 8-Hydroxy-5-O-beta-D-glucopyranosylpsoralen CFN98663 425680-98-4 C17H16O10 = 380.3 5mg QQ客服:215959384
    香柑醇; 5-羟基-6,7-呋喃并香豆素; Bergaptol CFN98772 486-60-2 C11H6O4 = 202.2 20mg QQ客服:2159513211
    佛手苷内酯; Bergapten CFN98766 484-20-8 C12H8O4 = 216.2 20mg QQ客服:1413575084
    8-羟基佛手苷内酯; 8-Hydroxybergapten CFN90591 1603-47-0 C12H8O5 = 232.19 10mg QQ客服:215959384
    异茴芹灵; Isopimpinellin CFN98752 482-27-9 C13H10O5 = 246.2 20mg QQ客服:215959384
    Rivulobirin B; Rivulobirin B CFN99893 194145-29-4 C23H12O9 = 432.3 5mg QQ客服:2056216494
    三甲沙林; Trioxsalen CFN70355 3902-71-4 C14H12O3 = 228.2 5mg QQ客服:215959384
    花椒毒酚,花椒毒醇; Xanthotoxol CFN98016 2009-24-7 C11H6O4 = 202.2 20mg QQ客服:2159513211

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