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  • 黄芩苷

    Baicalin

    黄芩苷
    产品编号 CFN99111
    CAS编号 21967-41-9
    分子式 = 分子量 C21H18O11 = 446.37
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Scutellaria baicalensis Georgi.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    黄芩苷 CFN99111 21967-41-9 10mg QQ客服:1413575084
    黄芩苷 CFN99111 21967-41-9 20mg QQ客服:1413575084
    黄芩苷 CFN99111 21967-41-9 50mg QQ客服:1413575084
    黄芩苷 CFN99111 21967-41-9 100mg QQ客服:1413575084
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Universidade Federal de Goias (UFG) (Brazil)
  • Hamdard University (India)
  • Utah State University (USA)
  • Research Unit Molecular Epigenetics (MEG) (Germany)
  • Chungnam National University (Korea)
  • Universidad Miguel Hernández (Spain)
  • University of Stirling (United Kingdom)
  • Medical University of South Carolina (USA)
  • Julius Kühn-Institut (Germany)
  • Institute of Chinese Materia Medica (China)
  • Universidade de Franca (Brazil)
  • University of Bordeaux (France)
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  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Toxins (Basel).2021, 13(12):898.
  • Molecules.2022, 27(7):2116.
  • J Biochem Mol Toxicol.2017, 31(9)
  • Aging (Albany NY).2021, 13(19):22867-22882.
  • Front Endocrinol (Lausanne).2020, 11:568436.
  • SRM Institute of Sci&Tech2022, 34(1): 32-37
  • Cell Physiol Biochem.2017, 43(4):1425-1435
  • Food Funct.2020, 11(2):1322-1333.
  • Food Chem.2020, 313:126079
  • Oncol Rep.2019, 41(4):2453-2463
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • TCI CO.2019, US20190151257A1
  • Iranian Journal of Pharmaceutical Sciences2021, 17(2):25-36
  • Planta Med.2016, 82(13):1208-16
  • Horticulturae2020, 6(4),76.
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  • J Korean Soc Food Sci Nutr2023, 52(11):1101-1110
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  • ...
  • 生物活性
    Description: Baicalin has antioxidant, anti-inflammatory, anti-apoptotic, and neuroprotection actions, it is a known prolyl endopeptidase inhibitor, affects the GABA receptors, and reduces the expression of NF-κB. Baicalin may have significant therapeutic benefits against diabetic complications and atherosclerosis.
    Targets: Caspase | NF-kB | TNF-α | IL Receptor | ROS
    In vitro:
    Mol Immunol. 2002 Feb;38(10):781-91.
    Baicalin induces apoptosis via mitochondrial pathway as prooxidant.[Pubmed: 11841838]
    Baicalin is a flavonoid and a major component of a herbal medicine, Sho-saiko-to, which is commonly used for treatment of chronic hepatitis in Japan and China. Flavonoids including baicalin have been reported to not only function as anti-oxidants but also cause cytotoxic effect.
    METHODS AND RESULTS:
    We investigated the mechanism of baicalin-induced cytotoxicity in leukemia-derived T cell line, Jurkat cells. When cells were cultured with 50-200 microg/ml baicalin for 6h, caspase-3 was activated and then cells fell into apoptosis. Induction of apoptosis by baicalin was accompanied with the marginal generation of intracellular reactive oxygen species (ROS), the increase of the cytosolic fractions of cytochrome c, and the disruption of mitochondrial transmembrane potential (DeltaPsi(m)) prior to the activation of caspase-3. The pre-culture with 5 mM of buthionine sulfoximine (BSO), an inhibitor of glutathione (GSH) synthesis, facilitated baicalin-induced disruption of DeltaPsi(m) and induction of apoptosis. The pre-culture with N-benzyloxycarbonyl-valyl-alanyl-aspartyl fluoromethylketone (Z-VAD-fmk), a pan-caspase inhibitor, partially suppressed the induction of apoptosis. On the other hand, baicalin showed little toxic effect on peripheral blood mononuclear cells (PBMCs) from healthy volunteers.
    CONCLUSIONS:
    These results indicate that baicalin acts as a prooxidant and induces caspase-3 activation and apoptosis via mitochondrial pathway.
    2014 Jan 13;14:19.
    The protective effect of baicalin against renal ischemia-reperfusion injury through inhibition of inflammation and apoptosis[Pubmed: 24417870]
    Abstract Background: Renal ischemia-reperfusion injury (IRI) increases the rates of acute kidney failure, delayed graft function, and early mortality after kidney transplantation. The pathophysiology involved includes oxidative stress, mitochondrial dysfunction, and immune-mediated injury. The anti-oxidation, anti-apoptosis, and anti-inflammation properties of baicalin, a flavonoid glycoside isolated from Scutellaria baicalensis, have been verified. This study therefore assessed the effects of baicalin against renal IRI in rats. Methods: Baicalin was intraperitoneally injected 30 min before renal ischemia. Serum and kidneys were harvested 24 h after reperfusion. Renal function and histological changes were assessed. Markers of oxidative stress, the Toll-like receptor (TLR)2 and TLR4 signaling pathway, mitochondrial stress, and cell apoptosis were also evaluated. Results: Baicalin treatment decreased oxidative stress and histological injury, and improved kidney function, as well as inhibiting proinflammatory responses and tubular apoptosis. Baicalin pretreatment also reduced the expression of TLR2, TLR4, MyD88, p-NF-κB, and p-IκB proteins, as well as decreasing caspase-3 activity and increasing the Bcl-2/Bax ratio. Conclusions: Baicalin may attenuate renal ischemia-reperfusion injury by inhibiting proinflammatory responses and mitochondria-mediated apoptosis. These effects are associated with the TLR2/4 signaling pathway and mitochondrial stress.
    In vivo:
    BMB Rep. 2015 Mar 5. pii: 3111.
    Baicalin, baicalein and wogonin inhibits high glucose-induced vascular inflammation in vitro and in vivo.[Pubmed: 25739393]
    Vascular inflammatory process has been suggested to play a key role in initiation and progression of atherosclerosis, a major complication of diabetes mellitus.
    METHODS AND RESULTS:
    Thus, in this study, we attempted to determine whether three structurally related polyphenols found in the Chinese herb Huang Qui, namely baicalin, baicalein, and wogonin, can suppress vascular inflammatory processes induced by high glucose (HG) in human umbilical vein endothelial cells (HUVECs) and mice. Data showed that HG induced markedly increased vascular permeability, monocyte adhesion, expressions of cell adhesion molecules (CAMs), formation of reactive oxygen species (ROS) and activation of nuclear factor (NF)-κB. Remarkably, all of the above mentioned vascular inflammatory effects of HG were attenuated by pretreatment with baicalin, baicalein, and wogonin.
    CONCLUSIONS:
    Vascular inflammatory responses induced by HG are critical events underlying development of various diabetic complications, therefore, our results suggest that baicalin, baicalein, and wogonin may have significant therapeutic benefits against diabetic complications and atherosclerosis.
    Brain Res Bull. 2011 Jul 15;85(6):396-402.
    Baicalin attenuates global cerebral ischemia/reperfusion injury in gerbils via anti-oxidative and anti-apoptotic pathways.[Pubmed: 21600966 ]
    Baicalin is an important medicinal herb purified from the dry roots of Scutellaria baicalensis Georgi.
    METHODS AND RESULTS:
    The present study was undertaken to evaluate the neuroprotective effects of baicalin in gerbils subjected to transient global cerebral ischemic-reperfusion injury. Baicalin at doses of 50, 100 and 200mg/kg was intraperitoneally injected into the gerbils immediately after cerebral ischemia. Seven days after reperfusion, hematoxylin and eosin (HE) staining was performed to analyze hippocampal CA1 pyramidal damage histopathologically. In addition, in order to understand the potential protective mechanism of baicalin, we examined anti-oxidative enzymes, such superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), non-enzymatic scavenger glutathione (GSH) and measured the content of malondialdehyde (MDA) in hippocampus. The mRNA and protein expressions of BDNF were determined in ischemic hippocampus by real-time RT-PCR and Western blot, respectively. Evidence for neuronal apoptosis was detected by real-time RT-PCR, Western blot and caspase-3 activity measurement. Histopathological examination showed that the administration of baicalin by the dose of 100 and 200mg/kg significantly attenuated ischemia-induced neuronal cell damage. Reduced level of MDA, obviously elevated activities of SOD and GSH as well as GSH-PX were also found in baicalin-treated groups. Further investigation demonstrated that treatment with baicalin remarkably promoted the expression of BDNF and inhibited the expression of caspase-3 at mRNA and protein levels by real-time RT-PCR and Western blot, respectively. Besides, caspase-3 activity assay also elucidated that the administration of baicalin could significantly suppress caspase-3 in ischemic gerbils hippocampus.
    CONCLUSIONS:
    Theses findings suggest that baicalin's neuroprotection appears to be associated with its anti-oxidative and anti-apoptotic properties in global cerebral ischemia in the gerbils.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2403 mL 11.2015 mL 22.4029 mL 44.8059 mL 56.0073 mL
    5 mM 0.4481 mL 2.2403 mL 4.4806 mL 8.9612 mL 11.2015 mL
    10 mM 0.224 mL 1.1201 mL 2.2403 mL 4.4806 mL 5.6007 mL
    50 mM 0.0448 mL 0.224 mL 0.4481 mL 0.8961 mL 1.1201 mL
    100 mM 0.0224 mL 0.112 mL 0.224 mL 0.4481 mL 0.5601 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    Glychionide A; Glychionide A CFN92280 119152-50-0 C21H18O11 = 446.4 5mg QQ客服:2056216494
    去甲汉黄芩素-8-O-葡萄糖醛酸苷; Norwogonin-8-O-glucuronide CFN95423 118525-47-6 C21H18O11 = 446.4 5mg QQ客服:1457312923
    汉黄芩苷; Wogonoside CFN99710 51059-44-0 C22H20O11 = 460.39 20mg QQ客服:3257982914
    穿心莲黄酮苷C; Andrographidine C CFN97852 113963-39-6 C23H24O10 = 460.44 5mg QQ客服:1457312923
    5-Hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside; 5-Hydroxy-7,8-dimethoxy (2R)-flavanone-5-O-beta-D-glucopyranoside CFN95209 942626-74-6 C23H26O10 = 462.5 10mg QQ客服:1413575084
    穿心莲黄酮苷A; Andrographidine A CFN95210 113963-37-4 C23H26O10 = 462.5 10mg QQ客服:215959384
    白杨素-7-O-龙胆二糖苷; Chrysin 7-O-beta-gentiobioside CFN90833 88640-89-5 C27H30O14 = 578.5 5mg QQ客服:215959384
    木蝴蝶苷A; Oroxin A CFN99712 57396-78-8 C21H20O10 = 432.38 20mg QQ客服:1413575084
    黄芩苷; Baicalin CFN99111 21967-41-9 C21H18O11 = 446.37 20mg QQ客服:3257982914
    黄芩苷甲酯; Baicalin methyl ester CFN92283 82475-03-4 C22H20O11 = 460.4 20mg QQ客服:2056216494

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