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  • 异鼠李亭 3-龙胆二糖甙

    • 异鼠李亭 3-龙胆二糖甙

    Astragaloside

    异鼠李亭 3-龙胆二糖甙
    		产品编号 CFN99170
    CAS编号 17429-69-5
    分子式 = 分子量 C28H32O17 = 640.55
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The roots of Astragalus membranaceus (Fisch.) Bunge
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    异鼠李亭 3-龙胆二糖甙 CFN99170 17429-69-5 1mg QQ客服：1457312923
    异鼠李亭 3-龙胆二糖甙 CFN99170 17429-69-5 5mg QQ客服：1457312923
    异鼠李亭 3-龙胆二糖甙 CFN99170 17429-69-5 10mg QQ客服：1457312923
    异鼠李亭 3-龙胆二糖甙 CFN99170 17429-69-5 20mg QQ客服：1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
  • University of the Basque Country (Spain)
  • Sanford Burnham Medical Research Institute (USA)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Medizinische Universit?t Wien (Austria)
  • Universidade do Porto (Portugal)
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  • Tokyo Woman's Christian University (Japan)
  • John Innes Centre (United Kingdom)
  • University of Otago (New Zealand)
  • Max-Planck-Insitut (Germany)
  • Copenhagen University (Denmark)
  • More...
    • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Cells.2021, 10(11):2919.
  • Molecules.2022, 27(19):6651.
  • Univerzita Karlova2021, 20.500.11956.
  • J of Applied Biological Chem.2020, 63(2):147-152
  • J Ginseng Res.2020, 44(4):611-618.
  • Appl. Sci. 2021, 11(23),11099.
  • Plants (Basel).2020, 9(11):1555.
  • Nutrients.2020, 12(12):3638.
  • Chinese J of Tissue Engineering Res.2022, 26(17): 2636-2641.
  • Phytother Res.2022, 10.1002:ptr.7626.
  • Ecol Evol.2022, 12(11):e9459.
  • J Breast Cancer.2015, 18(2):112-118
  • Int J Mol Sci.2019, 20(16):E4015
  • Antioxidants (Basel).2023, 12(7):1324.
  • Plants (Basel).2021, 10(7):1376.
  • bioRxiv-Pharm.&Toxi.2022, 2022.481203.
  • National Academy Science Letters2023, s40009.
  • Redox Biology2024, 103197.
  • Nutrients.2021, 13(1):254.
  • Acta horticulturae2017, 1158:257-268
  • ACS Nano.2018, 12(4):3385-3396
  • Biomedicines.2022, 10(3):583.
  • Antioxidants (Basel).2020, 9(2): E119
  • ...
    • 生物活性
    Description: Astragaloside may protect against brain contusion and neuronal apoptosis after TBI by attenuating microglia activation in male rats. Astragalosides-induced apoptosis in NB4 cells may be associated with down-regulation of the expression of BCL-2 and NF-κB, finally the relative activity of caspase-3 activated. Astragaloside has several pharmacological actions on cardiovascular system, including positive inotropic, anti-arrhythmia and anti-oxidant activities; it also has anti-apoptotic activity, which may contribute to the improvement of clinical outcomes in treating myocarditis with pharmaceutics of Astragalus membranaceus.
    Targets: Bcl-2/Bax | NF-kB | Caspase | NO | NOS | Trk receptor
    In vivo:
    Am J Chin Med. 2010;38(3):517-27.
    Protective effect of astragaloside on focal cerebral ischemia/reperfusion injury in rats.[Pubmed: 20503469 ]
    This study was to observe the neurological protective effects of Astragalosides (AST) on focal cerebral ischemia-reperfusion (I/R) injury in rats and to explore its possible mechanism.
    METHODS AND RESULTS:
    Male SD rats received right middle cerebral artery occlusion for 120 min and AST (40 mg/kg) was orally administered. The rats were decapitated 1, 3, 7, and 14 days after reperfusion. The neurological deficit score, infarct volume and water content of brain were measured; the activity of superoxide dismutase (SOD), lactate dehydrogenase (LDH) and nitric oxide synthase (NOS), and the content of malondialdehyde (MDA), lactate (LD) and nitric oxide (NO) of brain tissue were detected too. The expression of inducible nitric synthase (iNOS), nerve growth factor (NGF) and tropomyosin receptor kinase A (TrkA) mRNA were measured by RT-PCR or real-time PCR. AST could significantly reduce the neurological deficit score; infract volume and water content, increase SOD and LDH activities, decrease NOS activity and MDA, LD and NO content. AST treatment could down-regulate expression of iNOS mRNA, while, NGF and TrkA mRNA were up-regulated.
    CONCLUSIONS:
    Our data suggest that AST have the protective effects on focal cerebral ischemia in rats at the different reperfusion time points, the mechanism may be related to the antioxidation, regulated the expressions of iNOS, NGF and TrkA mRNA.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 1.5612 mL 7.8058 mL 15.6116 mL 31.2232 mL 39.029 mL
    5 mM 0.3122 mL 1.5612 mL 3.1223 mL 6.2446 mL 7.8058 mL
    10 mM 0.1561 mL 0.7806 mL 1.5612 mL 3.1223 mL 3.9029 mL
    50 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.6245 mL 0.7806 mL
    100 mM 0.0156 mL 0.0781 mL 0.1561 mL 0.3122 mL 0.3903 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    异鼠李素-3,7-O-二葡萄糖苷; Isorhamnetin 3,7-O-diglucoside CFN91130 6758-51-6 C28H32O17 = 640.6 5mg QQ客服：2056216494
    异鼠李素-3-O-芸香苷-7-O-葡萄糖苷; Isorhamnetin-3-O-rutinoside-7-O-glucoside CFN95494 55481-91-9 C34H42O21 = 786.7 5mg QQ客服：2056216494
    异鼠李素-3-O-β-D-葡萄糖-7-O-β-D-龙胆双糖苷; Isorhamnetin 3-O-beta-D-glucose-7-O-beta-D-gentiobioside CFN91845 60778-00-9 C34H42O22 = 802.7 5mg QQ客服：1457312923
    异鼠李素-3-O-槐二糖-7-O-鼠李糖苷; Isorhamnetin 3-sophoroside-7-rhamnoside CFN90735 41328-75-0 C34H42O21 = 786.68 5mg QQ客服：2056216494
    柠檬黄素-3-O-β-D-葡萄糖苷; Limocitrin 3-O-beta-D-glucopyranoside CFN91697 38836-51-0 C23H24O13 = 508.4 5mg QQ客服：215959384
    柠檬黄素-3-O-芸香糖苷; Limocitrin-3-O-rutinoside CFN91693 79384-27-3 C29H34O17 = 654.6 5mg QQ客服：2056216494
    柠檬黄素-3-O-槐糖苷; Limocitrin-3-O-beta-D-sophoroside CFN91459 114882-19-8 C29H34O18 = 670.6 5mg QQ客服：1457312923
    异鼠李素-3-O-葡萄糖苷; Isorhamnetin-3-O-beta-D-Glucoside CFN99757 5041-82-7 C22H22O12 = 478.40 10mg QQ客服：2056216494
    异鼠李素 3-O-半乳糖苷; Isorhamnetin 3-O-galactoside CFN93036 6743-92-6 C22H22O12 = 478.40 5mg QQ客服：3257982914
    鼠李亭-3-O-半乳糖苷; Rhamnetin 3-galactoside CFN95116 62858-07-5 C22H22O12 = 478.4 10mg QQ客服：2159513211

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