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  • 中药标准品生产商,产品定制服务
  • 蒿甲醚

    Artemether

    蒿甲醚
    产品编号 CFN99184
    CAS编号 71963-77-4
    分子式 = 分子量 C16H26O5 = 298.38
    产品纯度 >=98%
    物理属性 White powder
    化合物类型 Sesquiterpenoids
    植物来源 The herbs of Artemisia annua L.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    蒿甲醚 CFN99184 71963-77-4 10mg QQ客服:1457312923
    蒿甲醚 CFN99184 71963-77-4 20mg QQ客服:1457312923
    蒿甲醚 CFN99184 71963-77-4 50mg QQ客服:1457312923
    蒿甲醚 CFN99184 71963-77-4 100mg QQ客服:1457312923
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Maryland School of Medicine (USA)
  • Auburn University (USA)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • Warszawski Uniwersytet Medyczny (Poland)
  • University of Minnesota (USA)
  • St. Jude Children Research Hospital (USA)
  • University of Illinois at Chicago (USA)
  • National Research Council of Canada (Canada)
  • University of Toronto (Canada)
  • National Cancer Institute (USA)
  • Shanghai Institute of Biochemistry and Cell Biology (China)
  • Sanford Burnham Medical Research Institute (USA)
  • Cornell University (USA)
  • Universidade Federal de Pernambuco (UFPE) (Brazil)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Industrial Crops and Products2019, 140:111612
  • Evid Based Complement Alternat Med.2021, 8855980.
  • Pharmaceuticals (Basel).2022, 15(5):591.
  • Preprints2021, doi:10.20944
  • Front Aging Neurosci.2019, 11:230
  • J Cell Mol Med.2018, 22(9):4236-4242
  • Current Pharmaceutical Analysis2017, 13(5)
  • Acta Physiologiae Plantarum2015, 37:1736
  • J Ethnopharmacol.2019, 228:132-141
  • Current Enzyme Inhibition2023, 19(1):55-64(10)
  • Molecules.2021, 26(6):1738.
  • Drug Des Devel Ther.2023, 17:2461-2479.
  • Appl. Sci. 2021, 11(17),7829
  • Journal of Apicultural Research2021, 60(1)
  • Evid Based Complement Alternat Med.2019, 2019:2135351
  • Neurotox Res.2022, 40(6):1937-1947.
  • Food Chem.2021, 337:128023.
  • Pharmacol Res.2022, 182:106346.
  • Chem Pharm Bull (Tokyo).2017, 65(9):826-832
  • Life Sci.2023, 317:121458.
  • J Appl Biol Chem2023, 66:455−461
  • Nutrients.2019, 12(1):E40
  • Phytomedicine.2017, 24:77-86
  • ...
  • 生物活性
    Description: Artemether is a novel sonosensitizer,which has neurotoxicity, anti-schistosomiasis, anticancer and antitumor activities. It is an antimalarial for the treatment of resistant strains of falciparum malaria.
    Targets: Antifection
    In vivo:
    Chem Commun (Camb). 2015 Mar 3;51(22):4681-4.
    Potential sonodynamic anticancer activities of artemether and liposome-encapsulated artemether.[Pubmed: 25691357]
    The potential application of artemether as a novel sonosensitizer for sonodynamic therapy (SDT) was explored and illustrated for the first time. In addition, liposome-encapsulated artemether exhibited significantly enhanced sonodynamic anticancer activity. Our findings indicated that artemisinin derivatives may serve as a new kind of sonosensitizer for SDT.
    Acta Trop. 2002 May;82(2):175-81.
    Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia.[Pubmed: 12020890]
    Two decades ago, a group of Chinese scientists discovered the antischistosomal properties of artemether, a derivative of the antimalarial drug artemisinin. However, it was only recently that the importance of this finding was recognized internationally, following a collaborative effort between Chinese, European and African scientists, who investigated the effects of artemether against the major human schistosome species.
    METHODS AND RESULTS:
    Laboratory studies revealed that artemether exhibits the highest activity against juvenile stages of the parasites, while adult worms are significantly less susceptible. There was no indication of neurotoxicity following repeated high doses of artemether given fortnightly for up to 5 months. Randomized controlled clinical trials confirmed that artemether, orally administered at a dose of 6 mg/kg once every 2-3 weeks, results in no drug-related adverse effects, and significantly reduces the incidence and intensity of schistosome infections. The risk that these treatment regimens might select for resistance, particularly for resistant-plasmodia, appears to be low. Combined treatment with artemether and praziquantel, given to animals harbouring juvenile and adult schistosome worms, resulted in significantly higher worm burden reductions than each drug administered singly.
    CONCLUSIONS:
    In conclusion, artemether-integrated with other control strategies-has considerable potential for reducing the current burden of schistosomiasis in different epidemiological settings.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 3.3514 mL 16.7572 mL 33.5143 mL 67.0286 mL 83.7858 mL
    5 mM 0.6703 mL 3.3514 mL 6.7029 mL 13.4057 mL 16.7572 mL
    10 mM 0.3351 mL 1.6757 mL 3.3514 mL 6.7029 mL 8.3786 mL
    50 mM 0.067 mL 0.3351 mL 0.6703 mL 1.3406 mL 1.6757 mL
    100 mM 0.0335 mL 0.1676 mL 0.3351 mL 0.6703 mL 0.8379 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    脱氧青蒿素; Deoxyartemisinin CFN97212 72826-63-2 C15H22O4 = 266.3 5mg QQ客服:3257982914
    双氢青蒿素; Dihydroartemisinin CFN99507 71939-50-9 C15H24O5 = 284.35 20mg QQ客服:1457312923
    蒿甲醚; Artemether CFN99184 71963-77-4 C16H26O5 = 298.38 20mg QQ客服:2056216494
    青蒿素; Artemisinin CFN99011 63968-64-9 C15H22O5 = 282.3 20mg QQ客服:2159513211
    α-双氢青蒿素; alpha-Dihydroartemisinin CFN90485 81496-81-3 C15H24O5 = 284.34 20mg QQ客服:2159513211
    青蒿琥酯; 青蒿脂; Artesunate CFN90313 88495-63-0 C19H28O8 = 384.42 20mg QQ客服:2159513211

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