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  • 芹菜素-7-O-葡萄糖醛酸苷

    Apigenin-7-glucuronide

    芹菜素-7-O-葡萄糖醛酸苷
    产品编号 CFN98500
    CAS编号 29741-09-1
    分子式 = 分子量 C21H18O11 = 446.36
    产品纯度 >=98%
    物理属性 Yellow powder
    化合物类型 Flavonoids
    植物来源 The herbs of Phlomis tuberosa.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    芹菜素-7-O-葡萄糖醛酸苷 CFN98500 29741-09-1 10mg QQ客服:3257982914
    芹菜素-7-O-葡萄糖醛酸苷 CFN98500 29741-09-1 20mg QQ客服:3257982914
    芹菜素-7-O-葡萄糖醛酸苷 CFN98500 29741-09-1 50mg QQ客服:3257982914
    芹菜素-7-O-葡萄糖醛酸苷 CFN98500 29741-09-1 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Nanjing University of Chinese Medicine (China)
  • Universidad Industrial de Santander (Colombia)
  • St. Jude Children Research Hospital (USA)
  • Kyung Hee University (Korea)
  • Guangzhou Institutes of Biomedicine and Health (China)
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Agricultural Research Organization (ARO) (Israel)
  • Monash University (Australia)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Medicine and Pharmacy (Romania)
  • Heinrich-Heine-University Düsseldorf (Germany)
  • Universidad Miguel Hernández (Spain)
  • Nicolaus Copernicus Uniwersity (Poland)
  • Universitas islam negeri Jakarta (Indonesia)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • Food Chem.2017, 221:1135-1144
  • Molecules.2019, 24(23):E4303
  • Industrial Crops and Products2020, 146:112186
  • Molecules.2019, 24(22):E4022
  • Biofactors.2018, 44(2):168-179
  • J Nat Med.2018, 72(3):734-744
  • Psychopharmacology (Berl).2020, 10.1007
  • Antioxidants (Basel).2020, 9(6):466.
  • J of Applied Pharmaceutical Science2020, 10(1):077-082
  • Nutrients.2023, 15(13):2960.
  • The Journal of Internal Korean Medicine2015, 36(4):486-497
  • J Biol Chem.2014, 289(3):1723-31
  • Applied Biological Chemistry2023, 66:85.
  • The Korea Journal of Herbology2020, 35(3):33-45.
  • Academic J of Second Military Medical University2018, 39(11)
  • J Ethnopharmacol.2017, 196:75-83
  • J. of The Korean Society of Food Culture2017, 144-149
  • United States Patent Application2020, 20200038363
  • Pharmacol Res.2022, 182:106346.
  • Front Plant Sci.2020, 10:1705
  • Sci Rep.2021, 11(1):21038.
  • Int J Mol Sci.2018, 19(9):E2528
  • Evid Based Complement Alternat Med.2020, 2020:9416962.
  • ...
  • 生物活性
    Description: Apigenin-7-glucuronide possesses multiple pharmacological activities, including anti-oxidant, anti-complement, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively. Apigenin 7-O-β-D-glucuronide protects mice from LPS-induced endotoxin shock by inhibiting proinflammatory cytokine production, it may be used as a dietary complement for health promotion.
    Targets: NO | PGE | TNF-α | NOS | COX | AP-1 | ERK | p38MAPK | MMP-3 | MMP-8 | MMP-9 | MMP-13
    In vitro:
    Planta Med . 2017 Jul;83(11):901-911.
    Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids[Pubmed: 28288492]
    Abstract Metalloproteases are a family of zinc-containing endopeptidases involved in a variety of pathological disorders. The use of flavonoid derivatives as potential metalloprotease inhibitors has recently increased.Particular plants growing in Sicily are an excellent yielder of the flavonoids luteolin, apigenin, and their respective glycoside derivatives (7-O-rutinoside, 7-O-glucoside, and 7-O-glucuronide).The inhibitory activity of luteolin, apigenin, and their respective glycoside derivatives on the metalloproteases MMP-1, MMP-3, MMP-13, MMP-8, and MMP-9 was assessed and rationalized correlating in vitro target-oriented screening and in silico docking.The flavones apigenin, luteolin, and their respective glucosides have good ability to interact with metalloproteases and can also be lead compounds for further development. Glycones are more active on MMP-1, -3, -8, and -13 than MMP-9. Collagenases MMP-1, MMP-8, and MMP-13 are inhibited by compounds having rutinoside glycones. Apigenin and luteolin are inactive on MMP-1, -3, and -8, which can be interpreted as a better selectivity for both -9 and -13 peptidases. The more active compounds are apigenin-7-O-rutinoside on MMP-1 and luteolin-7-O-rutinoside on MMP-3. The lowest IC50 values were also found for apigenin-7-O-glucuronide, apigenin-7-O-rutinoside, and luteolin-7-O-glucuronide. The glycoside moiety might allow for a better anchoring to the active site of MMP-1, -3, -8, -9, and -13. Overall, the in silico data are substantially in agreement with the in vitro ones (fluorimetric assay).
    Biomed Pharmacother . 2018 Nov;107:1505-1513.
    Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN[Pubmed: 30257368]
    Abstract Background: Scutellarin is a naturally flavone glycoside that has been shown to exhibit anti-proliferative and anti-apoptotic activities among various human malignancies. However, the anti-cancer effect of Scutellarin in Renal cell carcinoma (RCC) and the underlying mechanism remains unclear. Methods and materials: RCC cell lines ACHN and 786-O were treated with different concentrations (0-210 μM) of Scutellarin in vitro. Cell viability and proliferation were investigated by MTT and colony formation assays. Cell invasion and migration were detected by Transwell assays. Cell apoptosis and cell cycle distribution was measured by flow cytometry. Western blot was used to investigate the expression levels of crucial proteins. Xenograft tumor model was established to evaluate tumor growth in vivo. Results: Scutellarin significantly inhibited RCC cell proliferation in a dose- and time- dependent manner. Treatment of RCC cells with Scutellarin (30, 60, and 90 μM) markedly induced apoptosis and cell cycle arrested at G0/G1 phase in a concentration-dependent characteristic. Cell invasion and migration capacities of RCC cells were also dose-dependently suppressed by Scutellarin treatment. Western blot assays revealed that the crucial proteins including cyclin D1, CDK2, Bcl2, MMP-2, and MMP-9 were significantly reduced while Bax, cleaved caspase 3 and p21 were increased by Scutellarin in RCC cells. In vivo assay indicated that Scutellarin possessed anti-cancer effect on xenograft without triggering toxic effect. Mechanically, Scutellarin dramatically increased the protein level of phosphatase and tensin homologue (PTEN) and inhibited the activity of P13K/AKT/mTOR signaling. Ectopic expression of PTEN enhanced the inhibitory effect of Scutellarin on RCC proliferation while knockdown of PTEN abrogated it through regulating its downstream P13K/AKT/mTOR signaling pathway. Conclusion: Scutellarin inhibited RCC cell proliferation and invasion partially by enhancing the expression of PTEN through inhibition of P13K/AKT/mTOR pathway, suggesting that Scutellarin might serve as a potential therapeutic agent in RCC treatment. Keywords: P13K/AKT/mTOR; PTEN; Proliferation; Renal cancer; Scutellarin.
    In vivo:
    Food Funct. 2016 Feb;7(2):1002-13.
    Apigenin-7-O-β-D-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock.[Pubmed: 26750400 ]
    Apigenin-7-O-β-D-glucuronide (Apigenin-7-glucuronide,AG), an active flavonoid derivative isolated from the agricultural residue of Juglans sigillata fruit husks, possesses multiple pharmacological activities, including anti-oxidant, anti-complement, and aldose reductase inhibitory activities. To date, no report has identified the anti-inflammatory mechanisms of AG.
    METHODS AND RESULTS:
    This study was therefore designed to characterize the molecular mechanisms of AG on lipopolysaccharide (LPS)-induced inflammatory cytokines in RAW 264.7 cells and on endotoxin-induced shock in mice. AG suppressed the release of nitric oxide (NO), prostaglandin E2 (PGE2), and tumour necrosis factor-α (TNF-α) in LPS-stimulated RAW 264.7 macrophages in a dose-dependent manner without affecting cell viability. Additionally, AG suppressed LPS-induced mRNA expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-α. AG treatment decreased the translocation of c-Jun into the nucleus, and decreased activator protein-1 (AP-1)-mediated luciferase activity through the inhibition of both p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) phosphorylation. Consistent with the in vitro observations, AG protected mice from LPS-induced endotoxin shock by inhibiting proinflammatory cytokine production.
    CONCLUSIONS:
    Taken together, these results suggest that AG may be used as a source of anti-inflammatory agents as well as a dietary complement for health promotion.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.2403 mL 11.2017 mL 22.4034 mL 44.8069 mL 56.0086 mL
    5 mM 0.4481 mL 2.2403 mL 4.4807 mL 8.9614 mL 11.2017 mL
    10 mM 0.224 mL 1.1202 mL 2.2403 mL 4.4807 mL 5.6009 mL
    50 mM 0.0448 mL 0.224 mL 0.4481 mL 0.8961 mL 1.1202 mL
    100 mM 0.0224 mL 0.112 mL 0.224 mL 0.4481 mL 0.5601 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    野黄芩素-7-O-葡萄糖苷; Scutellarein-7-O-glucoside CFN95082 26046-94-6 C21H20O11 = 448.4 5mg QQ客服:1413575084
    野黄芩苷; Scutellarin CFN99112 27740-01-8 C21H18O12 = 462.37 20mg QQ客服:1457312923
    野黄芩苷甲酯; Scutellarin methylester CFN90695 119262-68-9 C22H20O12 = 476.39 20mg QQ客服:215959384
    高车前苷; Homoplantaginin CFN90344 17680-84-1 C22H22O11 = 462.40 20mg QQ客服:2159513211
    高车前素 7-O-新橙皮糖苷; Hispidulin 7-O-neohesperidoside CFN90892 156186-00-4 C28H32O15 = 608.6 5mg QQ客服:215959384
    Comanthosid B; Comanthosid B CFN91174 70938-60-2 C23H22O12 = 490.4 5mg QQ客服:3257982914
    Comanthosid A; Comanthosid A CFN91173 70938-59-9 C24H24O12 = 504.5 5mg QQ客服:215959384
    高车前素-4'-O-β-D-葡萄糖苷; Hispidulin 4'-O-beta-D-glucopyranoside CFN91833 244285-12-9 C22H22O11 = 462.4 5mg QQ客服:1457312923
    滨蓟黄甙; Cirsimarin CFN96507 13020-19-4 C23H24O11 = 476.43 5mg QQ客服:215959384
    5,8,4'-三羟基-7-甲氧基黄酮8-O-葡萄糖甙; 5,8,4'-Trihydroxy-7-methoxyflavone 8-O-glucoside CFN97699 710952-13-9 C22H22O11 = 462.41 5mg QQ客服:1413575084

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