红曲黄素

Ankaflavin

	产品编号	CFN91602
	CAS编号	50980-32-0
	分子式 = 分子量	C₂₃H₃₀O₅ = 386.48
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Miscellaneous
	植物来源	From Monascus
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
红曲黄素	CFN91602	50980-32-0	1mg	QQ客服：215959384
红曲黄素	CFN91602	50980-32-0	5mg	QQ客服：215959384
红曲黄素	CFN91602	50980-32-0	10mg	QQ客服：215959384
红曲黄素	CFN91602	50980-32-0	20mg	QQ客服：215959384

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Description:

Ankaflavin, isolated from Monascus-Fermented red rice, is a PPARγ agonist with anti-inlfammatory activity. Ankaflavin exhibits selective cytotoxic effect and induces cell death on cancer cells. Ankaflavin has anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects.

In vitro:

Nat Prod Res . 2020 Jun;34(11):1630-1635.

Characterization of ankaflavin from Penicillium aculeatum and its cytotoxic properties[Pubmed: 30587035]

The pigment was extracted from Penicillium aculeatum, purified and characterized as Ankaflavin by spectroscopic analysis. The stability of the pigment was determined under various conditions and was found to possess high stability. The cytotoxicity property of the purified pigment was determined by MTT assay in MCF-7, HCT116 and PC-3 and the studies were compared with its activity in CHOK1 cells. In MCF-7 and in CHOK 1 cells, the pigment exhibited very less toxicity. However, significant cytotoxicity was observed in HCT116 and PC-3 cells with IC50 of 162 μg mL-1 and 85 μg mL-1 for HCT116 and PC-3 cells respectively. In vitro toxicity was tested by haemolysis assay and MTT assay in HEK 293 cells. The pigment showed least cytotoxicity (<5%) at 160 and 320 μg mL-1 concentrations HEK 293 cells and negligible (<5%) toxicity on human erythrocytes at 160 and 320 μg mL-1, the highest concentrations tested.

J Agric Food Chem . 2016 Dec 14;64(49):9326-9334.

Ankaflavin and Monascin Induce Apoptosis in Activated Hepatic Stellate Cells through Suppression of the Akt/NF-κB/p38 Signaling Pathway[Pubmed: 27960292]

The increased proliferation of activated hepatic stellate cells (HSCs) is associated with hepatic fibrosis and excessive extracellular matrix (ECM)-protein production. We examined the inhibitory effects of the Monascus purpureus-fermented metabolites, ankaflavin and monascin (15 and 30 μM), on the Akt/nuclear factor (NF)-κB and p38 mitogen-activated protein kinase (MAPK) signaling pathways in HSC-T6 (activated hepatic stellate cell line). Ankaflavin and monascin (30 μM) induced apoptosis and significantly inhibited cell growth (cell viabilities: 80.2 ± 5.43% and 62.8 ± 8.20%, respectively, versus control cells; P < 0.05). Apoptosis and G1 phase arrest (G1 phase percentages: 76.1 ± 2.85% and 79.9 ± 1.80%, respectively, versus control cells 65.9 ± 4.94%; P < 0.05) correlated with increased p53 and p21 levels and caspase 3 activity and decreased cyclin D1 and Bcl-2-family protein levels (P < 0.05, all cases). The apoptotic effects of ankaflavin and monascin were HSC-T6-specific, suggesting their potential in treating liver fibrosis.

In vivo:

Free Radic Biol Med . 2012 Dec 1;53(11):2008-2016.

Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo[Pubmed: 23022408]

Ankaflavin (AK) is an active compound having anti-inflammatory, anti-cancer, antiatherosclerotic, and hypolipidemic effects. We have previously reported that AK acts as an antioxidant and antidiabetic drug; however, the mechanism by which AK prevents diabetes remains unknown. Hyperglycemia is associated with protein glycation, which produces advanced glycation end-products (AGEs). Methylglyoxal (MG)-a metabolite of carbohydrates-is believed to cause insulin resistance by inducing inflammation and pancreas damage. In this work, diabetes was induced in Wistar rats (4 weeks of age) by treating them with MG (600 mg/kg bw) for 4 weeks. We observed that AK (10mg/kg bw) exerted peroxisome proliferator-activated receptor-γ (PPARγ) agonist activity, thereby enhancing insulin sensitivity (as indicated by hepatic GLUT2 translocation, PTP1B suppression, and glucose uptake) by downregulating blood glucose and upregulating pancreatic and duodenal homeobox-1 and Maf-A expression and increasing insulin production in MG-induced rats. However, these effects were abolished by the administration of GW9662 (PPARγ antagonist), but the expression of hepatic heme oxygenase-1 (HO-1) and glutamate-cysteine ligase (GCL) was not suppressed in MG-induced rats. Therefore, the nuclear factor erythroid-related factor-2 (Nrf2) activation was investigated. AK did not affect hepatic Nrf2 mRNA or protein expression but significantly increased Nrf2 phosphorylation (serine 40), which was accompanied by increased transcriptional activation of hepatic HO-1 and GCL. These data indicated that AK protected rats from oxidative stress resulting from MG-induced insulin resistance. In contrast, these effects were not detected when the rats were treated with the antidiabetic drug rosiglitazone (10mg/kg bw). Moreover, we found that AK did not inhibit the generation of AGEs in vitro; however, the glutathione (GSH) levels in liver and pancreas of MG-induced rats were elevated in rats administered AK. Therefore, we believe that GSH may lower the MG level, which attenuates the formation of AGEs in the serum, kidney, liver, and pancreas of MG-induced rats. We also found that AK treatment reduced the production of inflammatory factors, such as tumor necrosis factor-α and interleukin-1β. Taken together, the results of our mechanistic study of MG-induced rats suggest that the protective effects of AK against diabetes are mediated by the upregulation of the signaling pathway of Nrf2, which enhances antioxidant activity and serves as a PPARγ agonist to enhance insulin sensitivity.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5875 mL	12.9373 mL	25.8746 mL	51.7491 mL	64.6864 mL
5 mM	0.5175 mL	2.5875 mL	5.1749 mL	10.3498 mL	12.9373 mL
10 mM	0.2587 mL	1.2937 mL	2.5875 mL	5.1749 mL	6.4686 mL
50 mM	0.0517 mL	0.2587 mL	0.5175 mL	1.035 mL	1.2937 mL
100 mM	0.0259 mL	0.1294 mL	0.2587 mL	0.5175 mL	0.6469 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
Hydramicromelin B; Hydramicromelin B	CFN89277	369391-55-9	C₁₅H₁₄O₇ = 306.27	5mg	QQ客服：2056216494
大车前苷; Plantamajoside	CFN99522	104777-68-6	C₂₉H₃₆O₁₆ = 640.6	20mg	QQ客服：2159513211
水苏糖; Stachyose	CFN90424	10094-58-3	C₂₄H₄₂O₂₁ = 666.57	20mg	QQ客服：3257982914
西红花苷3; Crocin 3	CFN95666	55750-85-1	C₃₂H₄₄O₁₄ = 652.7	10mg	QQ客服：1457312923

红曲黄素

Ankaflavin

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