异白当归脑

Anhydrobyankangelicin

	产品编号	CFN91705
	CAS编号	35214-81-4
	分子式 = 分子量	C₁₇H₁₆O₆ = 316.3
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Coumarins
	植物来源	The roots of Angelica dahurica
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
异白当归脑	CFN91705	35214-81-4	1mg	QQ客服：2159513211
异白当归脑	CFN91705	35214-81-4	5mg	QQ客服：2159513211
异白当归脑	CFN91705	35214-81-4	10mg	QQ客服：2159513211
异白当归脑	CFN91705	35214-81-4	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Fraunhofer-Institut für Molekularbiologie und Angewandte ?kologie IME (Germany)

Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)

Research Unit Molecular Epigenetics (MEG) (Germany)

Funda??o Universitária de Desenvolvimento (Brazil)

Mahatma Gandhi University (India)

Medizinische Universit?t Wien (Austria)

University of Indonesia (Indonesia)

University of Hull (United Kingdom)

Chulalongkorn University (Thailand)

Julius Kühn-Institut (Germany)

University of Wuerzburg (Germany)

University of Perugia (Italy)

University of Beira Interior (Portugal)

Johannes Gutenberg University Mainz (JGU) (Germany)

More...

Description:

Isobyakangelicol is a coumarin that can be found in the roots of Angelica dahurica. Isobyakangelicol inhibits the growth of HeLa and HepG2 cells, with IC50s of 70.04 μM and 17.97 μM.

In vitro:

Journal of Functional Foods Volume 20, January 2016, 453-462

Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activities[Reference: WebLink]

Angelica dahurica has been frequently used as a food additive and a folk medicinal herb in Asian countries. The aim of this study was to isolate key active compounds from A. dahurica with antioxidant and anticancer activities. Three new furocoumarin dimers and twenty known coumarins were obtained from A. dahurica. Their structures were identified by extensive 1D and 2D NMR, CD, and HR-ESIMS spectroscopic analyses and screened by UPLC-MS/MS. Imperatorin oxypeucedanin hydrate, xanthotoxol, bergaptol, and 5-methoxy-8-hydroxypsoralen exhibited moderate DPPH• scavenging activity and strong ABTS•+ scavenging activity. Isoimperatorin, phelloptorin, and pabularinone showed significant inhibition on HepG2 cells with IC50 values of 8.19, 7.49, and 7.46 μM, respectively. Furthermore, pabularinone also showed moderate inhibition on HeLa cells with an IC50 value of 13.48 μM. These results suggested that A. dahurica could be explored as new and potential natural antioxidants and cancer prevention agents for use in functional foods.

In vivo:

J Pharm Biomed Anal . 2019 Sep 10;174:43-49.

Tissue distribution study of Angelica dahurica cv. Yubaizhi in rat by ultra-performance liquid chromatography with tandem mass spectrometry[Pubmed: 31153136]

A sensitive and specific ultra-performance liquid chromatographic-tandem mass (UPLC-MS/MS) spectrometric method was established to investigate tissue distribution of fourteen coumarins of Angelica Dahurica cv. Yubaizhi roots (ADYR) in rat tissues, including isoimperatorin (1), imperatorin (2), isooxypeucedanin (3), byakangelicin (4), oxypeucedanin hydrate (5), bergapten (6), 2"R-neobyakangelicol (7), phellopterin (8), xanthotoxin (9), isopimpinellin (10), oxypeucedanin ethanolate (11), isobyakangelicol (12), columbianetin (13), (-)-marmesin (14). Detection was performed on a triple quadrupole mass spectrometer in multiple-reaction-mode (MRM). The method established in this assay was successfully applied to tissue distribution study of the selected 14 coumarins after oral administration of the extract of ADYR in rat tissues, including heart, liver, spleen, lung, kidney, stomach, small intestine, muscle, testis, and brain. Tissue distribution characteristics of the fourteen coumarins were clearly elucidated, and the results of this study indicated that the fourteen coumarins were distributed to rat tissues rapidly and could be detected in all of the selected tissues after oral administration. Concentrations of the coumarins were obviously higher in kidney, liver and stomach tissues, and lower in testis, brain and muscle tissues. As an important part of ADMET/Act. study on ADYR, the tissue distribution of multiple coumarins of ADYR in rats provides a significant basis for better evaluation of the metabolism and disposition process in vivo of the herb medicine. The information provided in this research is very useful for further understanding of the metabolic mechanism of ADYR in vivo.

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.1616 mL	15.8078 mL	31.6156 mL	63.2311 mL	79.0389 mL
5 mM	0.6323 mL	3.1616 mL	6.3231 mL	12.6462 mL	15.8078 mL
10 mM	0.3162 mL	1.5808 mL	3.1616 mL	6.3231 mL	7.9039 mL
50 mM	0.0632 mL	0.3162 mL	0.6323 mL	1.2646 mL	1.5808 mL
100 mM	0.0316 mL	0.1581 mL	0.3162 mL	0.6323 mL	0.7904 mL

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
巴马司他; Batimastat (BB-94)	CFN60437	130370-60-4	C₂₃H₃₁N₃O₄S₂ = 477.64	5mg	QQ客服：1413575084
3-乙酰氧基-8(17),13E-劳丹二烯-15-酸; 3-Acetoxy-8(17),13E-labdadien-15-oic acid	CFN97090	63399-37-1	C₂₂H₃₄O₄ = 362.5	5mg	QQ客服：1413575084
西松烷酚醇; Nephthenol	CFN91050	53915-41-6	C₂₀H₃₄O = 290.49	5mg	QQ客服：1457312923
丝立尼亭; Selinidin	CFN90570	19427-82-8	C₁₉H₂₀O₅ = 328.4	5mg	QQ客服：215959384

异白当归脑

Anhydrobyankangelicin

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