氯化乙酰胆碱；乙酰氯化胆碱

Acetylcholine chloride

	产品编号	CFN90038
	CAS编号	60-31-1
	分子式 = 分子量	C₇H₁₆ClNO₂ = 181.66
	产品纯度	>=98%
	物理属性	White powder
	化合物类型	Alkaloids
	植物来源
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产品名称	产品编号	CAS编号	包装	QQ客服
氯化乙酰胆碱；乙酰氯化胆碱	CFN90038	60-31-1	10mg	QQ客服：1413575084
氯化乙酰胆碱；乙酰氯化胆碱	CFN90038	60-31-1	20mg	QQ客服：1413575084
氯化乙酰胆碱；乙酰氯化胆碱	CFN90038	60-31-1	50mg	QQ客服：1413575084
氯化乙酰胆碱；乙酰氯化胆碱	CFN90038	60-31-1	100mg	QQ客服：1413575084

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Description:

Acetylcholine Chloride is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. Acetylcholine chloride in micromolar concentrations significantly inhibit p53 mutant peptide aggregation in vitro, and could be promising candidate for p53 mutant/ misfolded protein aggregation inhibition, and mutations of tumor suppressor protein p53 are present in almost about 50% of all cancers.

Targets:

p53 | AChR

In vitro:

Protein Pept Lett. 2017;24(4):353-357.

Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride.[Pubmed: 28117010]

Mutations of tumor suppressor protein p53 are present in almost about 50% of all cancers. It has been reported that the p53 mutations cause aggregation and subsequent loss of p53 function, leading to cancer progression.
METHODS AND RESULTS:
Here in this study we focus on the inhibitory effects of cationic osmolyte molecules acetylcholine chloride, and choline on an aggregation prone 10 amino acid p53 mutant peptide WRPILTIITL, and the corresponding wildtype peptide RRPILTIITL in vitro. The characterization tools used for this study include Thioflavin- T (ThT) induced fluorescence, transmission electron microscopy (TEM), congo red binding, turbidity, dynamic light scattering (DLS), and cell viability assays.
CONCLUSIONS:
The results show that acetylcholine chloride in micromolar concentrations significantly inhibit p53 mutant peptide aggregation in vitro, and could be promising candidate for p53 mutant/ misfolded protein aggregation inhibition.

In vivo:

Microvasc Res. 2011 Sep;82(2):190-7.

Acetylcholine chloride as a potential source of variability in the study of cutaneous vascular function in man.[Pubmed: 21601579]

Laser-Doppler flowmetry (LDF) coupled with Acetylcholine chloride (ACh) iontophoresis is increasingly recognized as a reliable non-invasive method to study the endothelial function. However, Acetylcholine chloride-vasodilation measurement appears highly variable possibly due to the Acetylcholine chloride pharmacological properties itself. These problems may be partially overcome by using methacholine chloride (MCh), a more stable synthetic agonist of muscarinic receptors, instead of Acetylcholine chloride. Therefore, we first studied the correlation between the two drugs and then the effects of (1) spatial variability (inter-site measurements), (2) temporal variability (inter-day measurements), (3) intra-day variability (morning versus evening), and (4) age on the variability of both Acetylcholine chloride-vasodilation and MCh-vasodilation.
METHODS AND RESULTS:
The endothelium-dependent vasodilation response to simultaneous iontophoretic applications (4 doses of 10s at 0.1mA with 2min of current-free interval) of Acetylcholine chloride(11mM) or MCh (10mM) was studied on the forearm of 40 healthy subjects (36 males, median 28yr, range 21-59yr). The percent change in perfusion (CVCpeak) from baseline and the area under the curve (CVC(AUC)) during iontophoresis were assessed. Inter-site, inter-day and intra-day coefficients of variation (CV) were studied for each drug as well as correlations between drugs and age. A linear relationship was found between ACh- and MCh-CVCpeak (r²=0.75, p=0.01) and between ACh- and MCh-CVC(AUC) (r²=0.55, p=0.02). MCh inter-site CV for both CVCpeak (12.2%) and CVC(AUC) (13.8%) was significantly lower than ACh inter-site CV for CVCpeak (15.5%) and CVC(AUC) (15.3%), respectively. MCh inter-day CV for CVCpeak (17.2%) and CVC(AUC) (14.6%) was significantly lower than ACh inter-day CV for CVCpeak (19.7%) and ACh CVC(AUC) (21.2%). For ACh and MCh, the CVCpeak and CVC(AUC) were higher at 16:00pm than at 11:00am (p<0.05 for all). Finally, both ACh- and MCh-CVCpeak exhibited a logarithmic decrease with age (r²=0.61, p<0.01 and r²=0.58, p<0.01).
CONCLUSIONS:
Although both drugs exhibited circadian and age variability, MCh exhibited less inter-site and interday variabilities than did Acetylcholine chloride for the evaluation of cutaneous endothelium-dependent vasodilation. These findings should be taken into account in studies of cutaneous vascular function by iontophoresis coupled with laser Doppler flowmetry.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
四甲基铵; Tetramethylammonium	CFN00093	51-92-3	C₄H₁₂N+ = 74.14	5mg	QQ客服：215959384
三甲胺氧化物; Trimethylamine oxide	CFN00096	1184-78-7	C₃H₉NO = 75.11	5mg	QQ客服：2056216494
N,N,N-Trimethyl-2-aminoethylphosphonate; N,N,N-Trimethyl-2-aminoethylphosphonate	CFN00097	14596-57-7	C₅H₁₄NO₃P = 167.14	5mg	QQ客服：3257982914
Trimethyl[3-(methylthio)propyl]ammonium(1+); Trimethyl[3-(methylthio)propyl]ammonium(1+)	CFN00098	61672-50-2	C₇H₁₈NS+ = 148.29	5mg	QQ客服：215959384
3-(Dimethylsulfonio)-N,N,N-trimethylpropanaminium(2+); 3-(Dimethylsulfonio)-N,N,N-trimethylpropanaminium(2+)	CFN00099	61672-51-3	C₈H₂₁NS₂+ = 163.33	5mg	QQ客服：2159513211
4-羟基苯甲酰胆碱; 4-Hydroxybenzoyl choline	CFN95158	5094-31-5	C₁₂H₁₈NO₃ = 224.3	20mg	QQ客服：2056216494
Trimethylvinylammonium(1+); Trimethylvinylammonium(1+)	CFN00100	13448-18-5	C₅H₁₂N+ = 86.16	5mg	QQ客服：215959384
氯化乙酰胆碱；乙酰氯化胆碱; Acetylcholine chloride	CFN90038	60-31-1	C₇H₁₆ClNO₂ = 181.66	20mg	QQ客服：215959384
甜菜碱; Betaine	CFN99546	107-43-7	C₅H₁₁NO₂ = 117.15	20mg	QQ客服：1457312923
盐酸甜菜碱; Betaine hydrochloride	CFN99547	590-46-5	C₅H₁₂ClNO₂ = 153.60	20mg	QQ客服：2159513211

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.5048 mL	27.5239 mL	55.0479 mL	110.0958 mL	137.6197 mL
5 mM	1.101 mL	5.5048 mL	11.0096 mL	22.0192 mL	27.5239 mL
10 mM	0.5505 mL	2.7524 mL	5.5048 mL	11.0096 mL	13.762 mL
50 mM	0.1101 mL	0.5505 mL	1.101 mL	2.2019 mL	2.7524 mL
100 mM	0.055 mL	0.2752 mL	0.5505 mL	1.101 mL	1.3762 mL

氯化乙酰胆碱；乙酰氯化胆碱

Acetylcholine chloride

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氯化乙酰胆碱； 乙酰氯化胆碱

Acetylcholine chloride

信息支持

联系方式

氯化乙酰胆碱；乙酰氯化胆碱