9-甲氧基铁屎米酮

9-Methoxycanthin-6-one

	产品编号	CFN92011
	CAS编号	74991-91-6
	分子式 = 分子量	C₁₅H₁₀N₂O₂ = 250.3
	产品纯度	>=98%
	物理属性	Yellow powder
	化合物类型	Alkaloids
	植物来源	The herbs of Eurycoma longifolia
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
9-甲氧基铁屎米酮	CFN92011	74991-91-6	1mg	QQ客服：215959384
9-甲氧基铁屎米酮	CFN92011	74991-91-6	5mg	QQ客服：215959384
9-甲氧基铁屎米酮	CFN92011	74991-91-6	10mg	QQ客服：215959384
9-甲氧基铁屎米酮	CFN92011	74991-91-6	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Texas A&M University (USA)

Mahatma Gandhi University (India)

Leibniz Institute of Plant Biochemistry (Germany)

Seoul National University of Science and Technology (Korea)

Max Rubner-Institut (MRI) (Germany)

Kamphaengphet Rajabhat University (Thailand)

Massachusetts General Hospital (USA)

University of East Anglia (United Kingdom)

Amity University (India)

Ain Shams University (Egypt)

Monash University (Australia)

Universidad Veracuzana (Mexico)

Srinakharinwirot University (Thailand)

University Medical Center Mainz (Germany)

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Description:

9-Methoxycanthin-6-one has anti-tumour activity, exhibits cytotoxic activity towards KB, LU-1, LNCaP, HL-60 cancer cells and other human cancer cell lines with IC50 values around 1-4 μg/mL.

In vitro:

Methods Mol Biol. 2009;547:359-69.

The Production of 9-methoxycanthin-6-one from Callus Cultures of (Eurycoma longifolia Jack) Tongkat Ali.[Pubmed: 19521859]

Plant cell culture technology is potentially useful in producing high-valued secondary metabolites. Eurycoma longifolia root extracts are consumed as a health tonic but more popularly used as an aphrodisiac. Studies on the aphrodisiac properties and the possible compounds involved have been widely studied.
METHODS AND RESULTS:
There are many potentially useful compounds reported from the root extracts of E. longifolia. However, studies on the in vitro production of useful compounds from this plant have not been reported. This chapter will describe methods of callus induction and extraction of 9-Methoxycanthin-6-one from E. longifolia Jack explants with emphasis on the tap and fibrous roots. This compound, known to have anti-tumour activity, is present in intact plant parts and in callus tissues of different explants.

Planta Med. 2002 Apr;68(4):355-8.

HPLC analysis of plasma 9-methoxycanthin-6-one from Eurycoma longifolia and its application in a bioavailability/pharmacokinetic study.[Pubmed: 11988862]

METHODS AND RESULTS:
A new and simple HPLC method using fluorescence detection was developed to determine 9-Methoxycanthin-6-one, an active compound of Eurycoma longifolia Jack in rat and human plasma. The method entailed direct injection of plasma sample after deproteinization using acetonitrile. The mobile phase comprised acetonitrile and distilled water (55 : 45, v/v). Analysis was run at a flow rate of 1.0 ml/min with the detector operating at an excitation wavelength of 371 nm and emission wavelength of 504 nm. The method was specific and sensitive with a detection limit of 0.6 ng/ml and a quantification limit of approximately 1.6 ng/ml.
CONCLUSIONS:
The method was applied in a pilot pharmacokinetic/bioavailability study of the compound in rats. Less than 1 % of the compound was found to be absorbed orally.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
铁屎米酮; Canthin-6-one	CFN98730	479-43-6	C₁₄H₈N₂O = 220.2	5mg	QQ客服：1413575084
铁屎米酮 N氧化物; Canthin-6-one N-oxide	CFN92010	60755-87-5	C₁₄H₈N₂O₂ = 236.2	5mg	QQ客服：2056216494
1-羟基-6-铁屎米酮; 1-Hydroxycanthin-6-one	CFN97287	80787-59-3	C₁₄H₈N₂O₂ = 236.2	5mg	QQ客服：1413575084
9-羟基铁屎米酮; 9-Hydroxycanthin-6-one	CFN92126	138544-91-9	C₁₄H₈N₂O₂ = 236.2	5mg	QQ客服：3257982914
10-羟基-6-铁屎米酮; 10-Hydroxycanthin-6-one	CFN94012	86293-41-6	C₁₄H₈N₂O₂ = 236.23	5mg	QQ客服：1457312923
9-甲氧基铁屎米酮; 9-Methoxycanthin-6-one	CFN92011	74991-91-6	C₁₅H₁₀N₂O₂ = 250.3	5mg	QQ客服：2056216494
9-甲氧基铁屎米酮 N氧化物; 9-Methoxycanthin-6-one-N-oxide	CFN92012	137739-74-3	C₁₅H₁₀N₂O₃ = 266.3	5mg	QQ客服：2159513211
1-羟基-9-甲氧基铁屎米酮; 1-Hydroxy-9-medroxycanthin-6-one	CFN92124	622408-85-9	C₁₅H₁₀N₂O₃ = 266.3	5mg	QQ客服：3257982914
11-羟基-6-铁屎米酮; 11-Hydroxycanthin-6-one	CFN92125	75969-83-4	C₁₄H₈N₂O₂ = 236.2	5mg	QQ客服：1457312923
9,10-二甲氧基铁屎米酮; 9,10-Dimethoxycanthin-6-one	CFN92127	155861-51-1	C₁₆H₁₂N₂O₃ = 280.3	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.9952 mL	19.976 mL	39.9521 mL	79.9041 mL	99.8801 mL
5 mM	0.799 mL	3.9952 mL	7.9904 mL	15.9808 mL	19.976 mL
10 mM	0.3995 mL	1.9976 mL	3.9952 mL	7.9904 mL	9.988 mL
50 mM	0.0799 mL	0.3995 mL	0.799 mL	1.5981 mL	1.9976 mL
100 mM	0.04 mL	0.1998 mL	0.3995 mL	0.799 mL	0.9988 mL