7-氧代-灵芝酸Z
7-Oxo-ganoderic acid Z
|
|
产品编号 |
CFN92998 |
| CAS编号 |
929248-72-6 |
| 分子式 = 分子量 |
C30H46O4 = 470.68 |
| 产品纯度 |
>=98% |
| 物理属性 |
Powder |
| 化合物类型 |
Triterpenoids |
| 植物来源 |
The fruit body of Ganoderma lucidum |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 7-氧代-灵芝酸Z |
CFN92998 |
929248-72-6 |
1mg |
QQ客服：215959384 |
| 7-氧代-灵芝酸Z |
CFN92998 |
929248-72-6 |
5mg |
QQ客服：215959384 |
| 7-氧代-灵芝酸Z |
CFN92998 |
929248-72-6 |
10mg |
QQ客服：215959384 |
| 7-氧代-灵芝酸Z |
CFN92998 |
929248-72-6 |
20mg |
QQ客服：215959384 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
我们的产品现已经出口到下面的研究机构与大学，并且还在增涨
University of Lodz (Poland)
Celltrion Chemical Research Institute (Korea)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Research Unit Molecular Epigenetics (MEG) (Germany)
University of Hull (United Kingdom)
Centrum Menselijke Erfelijkheid (Belgium)
University of Pretoria (South Africa)
CSIRO - Agriculture Flagship (Australia)
Worcester Polytechnic Institute (USA)
Universidade Federal de Santa Catarina (Brazil)
Mahatma Gandhi University (India)
University of Ioannina (Greece)
Korea Food Research Institute(KFRI) (Korea)
Indian Institute of Science (India)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
Int J Mol Sci.2020, 21(6):2190.
Appl. Sci.2020, 10(23), 8729
Cancers (Basel).2021, 13(6):1432.
Pharmaceutics.2022, 14(12):2765.
Front Pharmacol.2023, 14:1095083.
Evid Based Complement Alternat Med.2021, 2021:8847358.
Sustainability2021, 13(23),12981.
Molecules.2019, 24(16):E3003
| Description: |
7-Oxo-ganoderic acid Z shows strong inhibitory effects against α-glucosidase, it also exhibits inhibitory activities against the HMG-CoA reductase and acyl CoA acyltransferase. 7-Oxo-ganoderic acid Z can reduce cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependently with LC50s from 20.87 to 84.36 uM. |
| Targets: |
HMG-CoA Reductase |
| In vitro: |
| Phytochemistry. 2018 May;149:103-115. | | Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase.[Pubmed: 29490285 ] | Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum. Resinacein C was isolated from a natural source for the first time.
METHODS AND RESULTS:
The structures of all the above compounds were elucidated by extensive spectroscopic analysis and comparisons of their spectroscopic data with those reported in the literature. Furthermore, in an in vitro assay, Resinacein C, ganoderic acid Y, lucialdehyde C, 7-Oxo-ganoderic acid Z3, 7-Oxo-ganoderic acid Z, and lucidadiol showed strong inhibitory effects against α-glucosidase compared with the positive control drug acarbose.
CONCLUSIONS:
The structure-activity relationships of ganoderma triterpenes on α-glucosidase inhibition showed that the C-24/C-25 double bond is necessary for α-glucosidase inhibitory activity. Moreover, the carboxylic acid group at C-26 and the hydroxy group at C-15 play important roles in enhancing inhibitory effects of these triterpenes. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.1246 mL |
10.6229 mL |
21.2459 mL |
42.4917 mL |
53.1146 mL |
| 5 mM |
0.4249 mL |
2.1246 mL |
4.2492 mL |
8.4983 mL |
10.6229 mL |
| 10 mM |
0.2125 mL |
1.0623 mL |
2.1246 mL |
4.2492 mL |
5.3115 mL |
| 50 mM |
0.0425 mL |
0.2125 mL |
0.4249 mL |
0.8498 mL |
1.0623 mL |
| 100 mM |
0.0212 mL |
0.1062 mL |
0.2125 mL |
0.4249 mL |
0.5311 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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