7-氧代-灵芝酸Z

7-Oxo-ganoderic acid Z

	产品编号	CFN92998
	CAS编号	929248-72-6
	分子式 = 分子量	C₃₀H₄₆O₄ = 470.68
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Triterpenoids
	植物来源	The fruit body of Ganoderma lucidum
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
7-氧代-灵芝酸Z	CFN92998	929248-72-6	1mg	QQ客服：2056216494
7-氧代-灵芝酸Z	CFN92998	929248-72-6	5mg	QQ客服：2056216494
7-氧代-灵芝酸Z	CFN92998	929248-72-6	10mg	QQ客服：2056216494
7-氧代-灵芝酸Z	CFN92998	929248-72-6	20mg	QQ客服：2056216494

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Shanghai University of TCM (China)

Cornell University (USA)

Nanjing University of Chinese Medicine (China)

Siksha O Anusandhan University (India)

Washington State University (USA)

Seoul National University of Science and Technology (Korea)

The Australian National University (Australia)

Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)

University of Hertfordshire (United Kingdom)

Medical University of South Carolina (USA)

Yale University (USA)

Korea Intitute of Science and Technology (KIST) (Korea)

Hamdard University (India)

Universidad Industrial de Santander (Colombia)

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Description:

7-Oxo-ganoderic acid Z shows strong inhibitory effects against α-glucosidase, it also exhibits inhibitory activities against the HMG-CoA reductase and acyl CoA acyltransferase. 7-Oxo-ganoderic acid Z can reduce cell growth in three human carcinoma cells (Caco-2, HepG2, and HeLa cells) dose dependently with LC50s from 20.87 to 84.36 uM.

Targets:

HMG-CoA Reductase

In vitro:

Phytochemistry. 2018 May;149:103-115.

Lanostane triterpenes from the mushroom Ganoderma resinaceum and their inhibitory activities against α-glucosidase.[Pubmed: 29490285 ]

Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum. Resinacein C was isolated from a natural source for the first time.
METHODS AND RESULTS:
The structures of all the above compounds were elucidated by extensive spectroscopic analysis and comparisons of their spectroscopic data with those reported in the literature. Furthermore, in an in vitro assay, Resinacein C, ganoderic acid Y, lucialdehyde C, 7-Oxo-ganoderic acid Z3, 7-Oxo-ganoderic acid Z, and lucidadiol showed strong inhibitory effects against α-glucosidase compared with the positive control drug acarbose.
CONCLUSIONS:
The structure-activity relationships of ganoderma triterpenes on α-glucosidase inhibition showed that the C-24/C-25 double bond is necessary for α-glucosidase inhibitory activity. Moreover, the carboxylic acid group at C-26 and the hydroxy group at C-15 play important roles in enhancing inhibitory effects of these triterpenes.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
11-酮基灵芝酸DM; 11-Keto-ganoderic acid DM	CFN95593	N/A	C₃₀H₄₂O₅ = 482.7	5mg	QQ客服：2056216494
灵芝醇 D; Ganoderiol D	CFN95568	114567-45-2	C₃₀H₄₈O₅ = 488.7	5mg	QQ客服：1457312923
Lucidumol A; Lucidumol A	CFN95059	217476-73-8	C₃₀H₄₈O₄ = 472.7	5mg	QQ客服：1413575084
23S-羟基-11,15-二氧-灵芝酸DM; 23S-hydroxy-11,15-dioxo-ganoderic acid DM	CFN80433	1085273-49-9	C₃₀H₄₀O₇ = 512.63	5mg	QQ客服：215959384
新化合物19; New compound 19	CFN95538	N/A	C₃₂H₄₂O₈ = 554.7	5mg	QQ客服：1413575084
灵芝酸GS-3; Ganoderic acid GS-3	CFN95518	1206781-66-9	C₃₂H₄₆O₈ = 558.7	5mg	QQ客服：215959384
Resinacein D; Resinacein D	CFN95591	2231061-47-3	C₃₀H₄₆O₅ = 486.7	5mg	QQ客服：1413575084
11alpha-hydroxy-3,7-dioxo-5alpha-lanosta-8,24(E)-dien-26-oic acid; 11alpha-hydroxy-3,7-dioxo-5alpha-lanosta-8,24(E)-dien-26-oic acid	CFN95592	1245703-70-1	C₃₀H₄₄O₅ = 484.7	5mg	QQ客服：3257982914
丹芝酸E; Ganolucidic acid E	CFN95536	114567-50-9	C₃₀H₄₄O₅ = 484.7	5mg	QQ客服：215959384
新化合物22; New compound 22	CFN95570	N/A	C₃₀H₄₄O₆ = 500.7	5mg	QQ客服：1457312923

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1246 mL	10.6229 mL	21.2459 mL	42.4917 mL	53.1146 mL
5 mM	0.4249 mL	2.1246 mL	4.2492 mL	8.4983 mL	10.6229 mL
10 mM	0.2125 mL	1.0623 mL	2.1246 mL	4.2492 mL	5.3115 mL
50 mM	0.0425 mL	0.2125 mL	0.4249 mL	0.8498 mL	1.0623 mL
100 mM	0.0212 mL	0.1062 mL	0.2125 mL	0.4249 mL	0.5311 mL