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  • 灵芝酸TR

    Ganoderic acid TR

    灵芝酸TR
    产品编号 CFN92235
    CAS编号 862893-75-2
    分子式 = 分子量 C30H44O4 = 468.7
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Triterpenoids
    植物来源 The fruit body of Ganoderma lucidum
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    灵芝酸TR CFN92235 862893-75-2 1mg QQ客服:1413575084
    灵芝酸TR CFN92235 862893-75-2 5mg QQ客服:1413575084
    灵芝酸TR CFN92235 862893-75-2 10mg QQ客服:1413575084
    灵芝酸TR CFN92235 862893-75-2 20mg QQ客服:1413575084
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    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • University of Sao Paulo (Brazil)
  • Universiti Malaysia Pahang (Malaysia)
  • University of East Anglia (United Kingdom)
  • University of Zurich (Switzerland)
  • Instituto de Investigaciones Agropecuarias (Chile)
  • University of Wollongong (Australia)
  • FORTH-IMBB (Greece)
  • Cancer Research Initatives Foundation(CARIF) (Malaysia)
  • Sri Sai Aditya Institute of Pharmaceutical Sciences and Research (India)
  • University of Maryland (USA)
  • University of Queensland (Australia)
  • University of Vienna (Austria)
  • University of Helsinki (Finland)
  • Massachusetts General Hospital (USA)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • J Pharmaceut Biomed2020, 182:113110
  • South African J of Botany2020, 135:50-57
  • Sci Rep.2019, 9:12132
  • Int Immunopharmacol.2020, 90:107268.
  • Natural Product Communications2020, doi: 10.1177.
  • Plos One.2020, 10.1371
  • The Pharmaceutical Society of Japan2018, 138(4):571-579
  • Nutrients.2021, 13(8):2901.
  • Phytochemistry.2017, 141:162-170
  • Molecules.2021, 26(3):695.
  • New Zealand J. Forestry Sci.2014, 44:17
  • Int J Mol Sci.2018, 19(9):E2681
  • Drug Chem Toxicol.2020, 1-12.
  • Curr Eye Res.2018, 43(1):27-34
  • Toxicol In Vitro.2019, 59:161-178
  • Ulm University Medical Center2020, doi: 10.18725.
  • Molecules.2016, 21(6)
  • Acta Agriculturae Scandinavica2015, 381-383
  • Br J Pharmacol.2018, 175(6):902-923
  • Pharmaceuticals (Basel).2021, 14(7):633.
  • Cell Mol Biol(Noisy-le-grand)2019, 65(7):77-83
  • Pharmacognosy Journal, 2021, 13(5).
  • J Appl Toxicol.2020, 40(7):965-978.
  • ...
  • 生物活性
    Description: Ganoderic acid TR, a new lanostanoid with 5α-reductase inhibitory activity from the fruiting body of Ganoderma lucidum.
    Targets: 5-alpha Reductase
    In vitro:
    Sci Rep . 2015 Aug 26;5:13194.
    Inhibition of neuraminidase by Ganoderma triterpenoids and implications for neuraminidase inhibitor design[Pubmed: 26307417]
    Abstract Neuraminidase (NA) inhibitors are the dominant antiviral drugs for treating influenza in the clinic. Increasing prevalence of drug resistance makes the discovery of new NA inhibitors a high priority. Thirty-one triterpenoids from the medicinal mushroom Ganoderma lingzhi were analyzed in an in vitro NA inhibition assay, leading to the discovery of ganoderic acid T-Q and TR as two inhibitors of H5N1 and H1N1 NAs. Structure-activity relationship studies revealed that the corresponding triterpenoid structure is a potential scaffold for the design of NA inhibitors. Using these triterpenoids as probes we found, through further in silico docking and interaction analysis, that interactions with the amino-acid residues Arg292 and/or Glu119 of NA are critical for the inhibition of H5N1 and H1N1. These findings should prove valuable for the design and development of NA inhibitors.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 2.1336 mL 10.6678 mL 21.3356 mL 42.6712 mL 53.339 mL
    5 mM 0.4267 mL 2.1336 mL 4.2671 mL 8.5342 mL 10.6678 mL
    10 mM 0.2134 mL 1.0668 mL 2.1336 mL 4.2671 mL 5.3339 mL
    50 mM 0.0427 mL 0.2134 mL 0.4267 mL 0.8534 mL 1.0668 mL
    100 mM 0.0213 mL 0.1067 mL 0.2134 mL 0.4267 mL 0.5334 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    灵芝酸T-Q; Ganoderic acid T-Q CFN92237 112430-66-7 C32H46O5 = 510.7 5 mg QQ客服:3257982914
    胭脂虫酸; Coccinic acid CFN99083 107783-45-9 C30H46O3 = 454.7 5mg QQ客服:2159513211
    安五酸; Anwuweizonic acid CFN92727 117020-59-4 C30H46O3 = 454.7 5mg QQ客服:2056216494
    7-氧代-灵芝酸Z; 7-Oxo-ganoderic acid Z CFN92998 929248-72-6 C30H46O4 = 470.68 5mg QQ客服:1457312923
    灵芝酸DM; Ganoderic acid DM CFN99815 173075-45-1 C30H44O4 = 468.7 5mg QQ客服:2056216494
    23S-羟基-11,15-二氧-灵芝酸DM; 23S-hydroxy-11,15-dioxo-ganoderic acid DM CFN80433 1085273-49-9 C30H40O7 = 512.63 5mg QQ客服:1413575084
    灵芝酸GS-3; Ganoderic acid GS-3 CFN95518 1206781-66-9 C32H46O8 = 558.7 5mg QQ客服:2056216494
    灵芝酸Y; Ganoderic acid Y CFN90294 86377-52-8 C30H46O3 = 454.68 5mg QQ客服:2056216494
    灵芝酸SZ; Ganoderic acid SZ CFN97426 865543-37-9 C30H44O3 = 452.7 5mg QQ客服:1413575084
    灵芝酸S; Ganoderic acid S CFN99066 104759-35-5 C30H44O3 = 452.7 5mg QQ客服:3257982914

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