7-O-Acetylintermedine N-oxide

	产品编号	CFN00518
	CAS编号	685132-59-6
	分子式 = 分子量	C₁₇H₂₇NO₇ = 357.4
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Alkaloids
	植物来源	The herbs of Echium pininana
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
7-O-Acetylintermedine N-oxide	CFN00518	685132-59-6	1mg	QQ客服：2159513211
7-O-Acetylintermedine N-oxide	CFN00518	685132-59-6	5mg	QQ客服：2159513211
7-O-Acetylintermedine N-oxide	CFN00518	685132-59-6	10mg	QQ客服：2159513211
7-O-Acetylintermedine N-oxide	CFN00518	685132-59-6	20mg	QQ客服：2159513211

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

University of Dicle (Turkey)

FORTH-IMBB (Greece)

The Ohio State University (USA)

University of Queensland (Australia)

Max-Planck-Insitut (Germany)

University of Illinois (USA)

Massachusetts General Hospital (USA)

Georgia Institute of Technology (USA)

Monash University (Australia)

Mendel University in Brno (Czech Republic)

Biotech R&D Institute (USA)

Universidad de Ciencias y Artes de Chiapas (Mexico)

Aveiro University (Portugal)

University of Malaya (Malaysia)

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Description:

7-O-Acetylintermedine-N-oxide is a pyrrolizidine alkaloid isolated from Symphytum officinale. Pyrrolizidine alkaloids have adverse health effects and were classified as genotoxic, carcinogen and hepatotoxic.

In vivo:

EFSA Journal 2011;9(11):2406.

Scientific Opinion on Pyrrolizidine alkaloids in food and feed[Reference: WebLink]

The European Food Safety Authority (EFSA) was asked by the European Commission to deliver a scientific opinion on pyrrolizidine alkaloids (PA) in food and feed. PAs are toxins exclusively biosynthesised by plants. To date, approximately 600 different PAs are known. Results for 13,280 bulk honey and 1324 retail honey samples were provided to EFSA by one Member State and 351 feed samples were provided by a second Member State. The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) performed estimates of both acute and chronic exposure to PAs through honey for three different age groups. Although there might be other sources of PA exposure, due to lack of data the CONTAM Panel was not able to quantify dietary exposure from food other than honey. A number of PAs were identified as being of particular importance for food and feed. Based on the present knowledge of metabolism, activation, DNA adduct-formation, genotoxicity and carcinogenicity, the CONTAM Panel concluded that 1,2-unsaturated PAs may act as genotoxic carcinogens in humans. Therefore, the CONTAM Panel decided to apply the Margin of Exposure (MOE) approach. A benchmark dose lower confidence limit for a 10 % excess cancer risk (BMDL10) of 70 μg/kg b.w. per day for induction of liver haemangiosarcomas by lasiocarpine in male rats was calculated as the reference point for comparison with the estimated dietary exposure. The CONTAM Panel concluded that there is a possible health concern for those toddlers and children who are high consumers of honey. There is generally a low risk of PA poisoning in livestock and companion animals in the EU as most PA poisonings reported recently are due to accidental exposure.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
大尾摇碱-N-氧化物; Indicine N-oxide	CFN00284	41708-76-3	C₁₅H₂₅NO₆ = 315.37	5mg	QQ客服：1457312923
印美定; Intermedine	CFN00285	10285-06-0	C₁₅H₂₅NO₅ = 299.36	5mg	QQ客服：2056216494
印美定N-氧化物; Intermedine N-oxide	CFN00459	95462-14-9	C₁₅H₂₅NO₆ = 315.4	5mg	QQ客服：2056216494
7-Acetylintermedine; 7-Acetylintermedine	CFN00286	74243-01-9	C₁₇H₂₇NO₆ = 341.40	5mg	QQ客服：3257982914
7-O-Acetylintermedine N-oxide; 7-O-Acetylintermedine N-oxide	CFN00518	685132-59-6	C₁₇H₂₇NO₇ = 357.4	5mg	QQ客服：215959384
石松胺; Lycopsamine	CFN00287	10285-07-1	C₁₅H₂₅NO₅ = 299.37	5mg	QQ客服：215959384
7-乙酰基印美定; 7-Acetyllycopsamine	CFN00288	73544-48-6	C₁₇H₂₇NO₆ = 341.40	5mg	QQ客服：215959384
Petasinoside; Petasinoside	CFN00277	70474-34-9	C₂₈H₃₇NO₉ = 531.60	5mg	QQ客服：215959384
Thesinine; Thesinine	CFN00278	488-02-8	C₁₇H₂₁NO₃ = 287.36	5mg	QQ客服：2159513211
Ehretinine; Ehretinine	CFN00282	76231-29-3	C₁₆H₂₁NO₃ = 275.35	5mg	QQ客服：215959384

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.798 mL	13.9899 mL	27.9799 mL	55.9597 mL	69.9496 mL
5 mM	0.5596 mL	2.798 mL	5.596 mL	11.1919 mL	13.9899 mL
10 mM	0.2798 mL	1.399 mL	2.798 mL	5.596 mL	6.995 mL
50 mM	0.056 mL	0.2798 mL	0.5596 mL	1.1192 mL	1.399 mL
100 mM	0.028 mL	0.1399 mL	0.2798 mL	0.5596 mL	0.6995 mL