7-O-Acetylintermedine N-oxide
7-O-Acetylintermedine N-oxide
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 7-O-Acetylintermedine N-oxide |
CFN00518 |
685132-59-6 |
1mg |
QQ客服：1413575084 |
| 7-O-Acetylintermedine N-oxide |
CFN00518 |
685132-59-6 |
5mg |
QQ客服：1413575084 |
| 7-O-Acetylintermedine N-oxide |
CFN00518 |
685132-59-6 |
10mg |
QQ客服：1413575084 |
| 7-O-Acetylintermedine N-oxide |
CFN00518 |
685132-59-6 |
20mg |
QQ客服：1413575084 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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Korea Institute of Oriental Medicine (Korea)
Deutsches Krebsforschungszentrum (Germany)
Mahidol University (Thailand)
Universidade Federal de Goias (UFG) (Brazil)
Donald Danforth Plant Science Center (USA)
Institute of Pathophysiology Medical University of Vienna (Austria)
Centralised Purchases Unit (CPU), B.I.T.S (India)
University of Perugia (Italy)
University of British Columbia (Canada)
Shanghai Institute of Biochemistry and Cell Biology (China)
Rio de Janeiro State University (Brazil)
National Hellenic Research Foundation (Greece)
Istanbul University (Turkey)
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国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
7-O-Acetylintermedine-N-oxide is a pyrrolizidine alkaloid isolated from Symphytum officinale. Pyrrolizidine alkaloids have adverse health effects and were classified as genotoxic, carcinogen and hepatotoxic. |
| In vivo: |
| EFSA Journal 2011;9(11):2406. | | Scientific Opinion on Pyrrolizidine alkaloids in food and feed[Reference: WebLink] | | The European Food Safety Authority (EFSA) was asked by the European Commission to deliver a scientific opinion on pyrrolizidine alkaloids (PA) in food and feed. PAs are toxins exclusively biosynthesised by plants. To date, approximately 600 different PAs are known. Results for 13,280 bulk honey and 1324 retail honey samples were provided to EFSA by one Member State and 351 feed samples were provided by a second Member State. The EFSA Panel on Contaminants in the Food Chain (CONTAM Panel) performed estimates of both acute and chronic exposure to PAs through honey for three different age groups. Although there might be other sources of PA exposure, due to lack of data the CONTAM Panel was not able to quantify dietary exposure from food other than honey. A number of PAs were identified as being of particular importance for food and feed. Based on the present knowledge of metabolism, activation, DNA adduct-formation, genotoxicity and carcinogenicity, the CONTAM Panel concluded that 1,2-unsaturated PAs may act as genotoxic carcinogens in humans. Therefore, the CONTAM Panel decided to apply the Margin of Exposure (MOE) approach. A benchmark dose lower confidence limit for a 10 % excess cancer risk (BMDL10) of 70 μg/kg b.w. per day for induction of liver haemangiosarcomas by lasiocarpine in male rats was calculated as the reference point for comparison with the estimated dietary exposure. The CONTAM Panel concluded that there is a possible health concern for those toddlers and children who are high consumers of honey. There is generally a low risk of PA poisoning in livestock and companion animals in the EU as most PA poisonings reported recently are due to accidental exposure. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.798 mL |
13.9899 mL |
27.9799 mL |
55.9597 mL |
69.9496 mL |
| 5 mM |
0.5596 mL |
2.798 mL |
5.596 mL |
11.1919 mL |
13.9899 mL |
| 10 mM |
0.2798 mL |
1.399 mL |
2.798 mL |
5.596 mL |
6.995 mL |
| 50 mM |
0.056 mL |
0.2798 mL |
0.5596 mL |
1.1192 mL |
1.399 mL |
| 100 mM |
0.028 mL |
0.1399 mL |
0.2798 mL |
0.5596 mL |
0.6995 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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