7,4'-Dihydroxy-8-methylflavan

	产品编号	CFN96528
	CAS编号	82925-55-1
	分子式 = 分子量	C₁₆H₁₆O₃ = 256.30
	产品纯度	>=98%
	物理属性	Powder
	化合物类型	Flavonoids
	植物来源	The red resin of Dracaena cochinchinensis.
ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用

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产品名称	产品编号	CAS编号	包装	QQ客服
7,4'-Dihydroxy-8-methylflavan	CFN96528	82925-55-1	1mg	QQ客服：215959384
7,4'-Dihydroxy-8-methylflavan	CFN96528	82925-55-1	5mg	QQ客服：215959384
7,4'-Dihydroxy-8-methylflavan	CFN96528	82925-55-1	10mg	QQ客服：215959384
7,4'-Dihydroxy-8-methylflavan	CFN96528	82925-55-1	20mg	QQ客服：215959384

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ChemFaces的产品在许多优秀和顶级科学期刊中被引用

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089

Northeast Normal University Changchun (China)

University of Wollongong (Australia)

University of British Columbia (Canada)

University of Dicle (Turkey)

Hamdard University (India)

S.N.D.T. Women's University (India)

University of Amsterdam (Netherlands)

Universidade do Porto (Portugal)

University of Hertfordshire (United Kingdom)

Universite de Lille1 (France)

Universidade Federal de Santa Catarina (Brazil)

Sant Gadge Baba Amravati University (India)

Leibniz-Institut für Pflanzenbiochemie (IPB) (Germany)

Lund University (Sweden)

More...

Description:

7,4'-Dihydroxy-8-methylflavan can significantly promote mesenchymal stem cells (MSCs) osteogenic differentiation by increasing the levels of alkaline phosphatase (ALP) activity. 7,4'-Dihydroxy-8-methylflavan also has free radical scavenging properties.

In vitro:

J Pharm Biomed Anal. 2016 Sep 10;129:466-472.

Isolation and chatacterization of homoisoflavonoids from Dracaena cochinchinensis and their osteogenic activities in mouse mesenchymal stem cells.[Pubmed: 27497307 ]

METHODS AND RESULTS:
Two new homoisoflavonoids, dracaeconolide A (1) and dracaeconolide B (2), together with ten known compounds, namely (3R)-7,4'-dihydroxy-8-methoxyhomoisoflavane (3), (3R)-7-hydroxy-3-(4-hydroxybenzyl)chromane (4), (3R)-7,4'-dihydroxy-5-methoxy-homoisoflavane (5), (3R)-6,4'-dihydroxy-8-methoxyhomoisoflavan (6), 7,4'-Dihydroxy-8-methylflavan (7), (2R)-7,4'-dihydroxy-5-methoxy-8-methylflavan (8), 5,4'-dihydroxy-7-methoxy-6-methylflavane (9), 7,4'-dihydroxy-3'-methoxyflavan (10), 7,4'-dihydroxyflavan (11), 4,4'-dihydroxy-2,6-dimethoxydihydrochlcone (12), were isolated from the red resin of Dracaena cochinchinensis (dragon's blood, DB). All the compounds were then evaluated for their effects on mouse bone marrow-derived mesenchymal stem cells (MSCs) proliferation using CCK8 assay and their abilities in promoting MSCs differentiating into osteoblast through the assay of alkaline phosphatase (ALP) activity in vitro.
CONCLUSIONS:
Compounds 2, 3, 4, 7, 9, and 11, at a concentration of 10μM with no cytotoxicity, significantly promoted MSC osteogenic differentiation by increasing the levels of ALP activity to percents of 159.6±5.9, 167.6±10.9, 162.0±1.4, 151.3±4.0, 171.0±8.2, and 169.9±7.3 in relative to the control, respectively. The results of ALP staining were in accordance to that of ALP activity.

产品名称	产品编号	CAS编号	分子式 = 分子量	位单	联系QQ
7,4'-Dihydroxy-8-methylflavan; 7,4'-Dihydroxy-8-methylflavan	CFN96528	82925-55-1	C₁₆H₁₆O₃ = 256.30	5mg	QQ客服：2056216494
2H-1-苯并吡喃-5-醇; 2H-1-Benzopyran-5-ol	CFN92674	770729-34-5	C₁₇H₁₈O₄ = 286.3	5mg	QQ客服：2159513211
(2S)-2',4'-二羟基-7-甲氧基-8-异戊烯基黄烷; 2',4'-Dihydroxy-7-methoxy-8-prenylflavan	CFN96531	331954-16-6	C₂₁H₂₄O₄ = 340.42	5mg	QQ客服：2056216494
7,4'-二羟基-3'-异戊烯基黄烷; 7,4'-Dihydroxy-3'-prenylflavan	CFN98606	376361-96-5	C₂₀H₂₂O₃ = 310.4	5mg	QQ客服：215959384
小构树醇U; Kazinol U	CFN97839	1238116-48-7	C₂₀H₂₂O₄ = 326.39	5mg	QQ客服：3257982914
小构树醇A; Kazinol A	CFN92431	99624-28-9	C₂₅H₃₀O₄ = 394.5	5mg	QQ客服：3257982914
小构树醇B; Kazinol B	CFN97569	99624-27-8	C₂₅H₂₈O₄ = 392.5	5mg	QQ客服：1457312923
7,3'-二羟基-4'-甲氧基黄烷; 7,3'-Dihydroxy-4'-methoxyflavan	CFN97811	162290-05-3	C₁₆H₁₆O₄ = 272.30	5mg	QQ客服：2159513211
Trilepisflavan; Trilepisflavan	CFN96480	1443218-16-3	C₁₇H₁₈O₄ = 286.32	5mg	QQ客服：215959384
3',4',7-三甲氧基黄烷; 3',4',7-Trimethoxyflavan	CFN99264	116384-26-0	C₁₈H₂₀O₄ = 300.4	5mg	QQ客服：2056216494

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	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.9017 mL	19.5084 mL	39.0168 mL	78.0336 mL	97.5419 mL
5 mM	0.7803 mL	3.9017 mL	7.8034 mL	15.6067 mL	19.5084 mL
10 mM	0.3902 mL	1.9508 mL	3.9017 mL	7.8034 mL	9.7542 mL
50 mM	0.078 mL	0.3902 mL	0.7803 mL	1.5607 mL	1.9508 mL
100 mM	0.039 mL	0.1951 mL	0.3902 mL	0.7803 mL	0.9754 mL