Info: Read More
  • 中药标准品生产商,产品定制服务
  • 6-羟基黄酮

    6-Hydroxyflavone

    6-羟基黄酮
    产品编号 CFN70185
    CAS编号 6665-83-4
    分子式 = 分子量 C15H10O3 = 238.2
    产品纯度 >=98%
    物理属性 Powder
    化合物类型 Flavonoids
    植物来源 The leaves of Thymbra spicata.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
    提供自定义包装
    产品名称 产品编号 CAS编号 包装 QQ客服
    6-羟基黄酮 CFN70185 6665-83-4 10mg QQ客服:2056216494
    6-羟基黄酮 CFN70185 6665-83-4 20mg QQ客服:2056216494
    6-羟基黄酮 CFN70185 6665-83-4 50mg QQ客服:2056216494
    6-羟基黄酮 CFN70185 6665-83-4 100mg QQ客服:2056216494
    存储与注意事项
    1. 在您收到产品后请检查产品。如无问题,请将产品存入冰霜并且样品瓶保持密封,产品可以存放长达24个月(2-8摄氏度)。

    2. 只要有可能,产品溶解后,您应该在同一天应用于您的实验。 但是,如果您需要提前做预实验,或者需要全部溶解,我们建议您将溶液以等分试样的形式存放在-20℃的密封小瓶中。 通常,这些可用于长达两周。 使用前,打开样品瓶前,我们建议您将产品平衡至室温至少1小时。

    3. 需要更多关于溶解度,使用和处理的建议? 请发送电子邮件至:service@chemfaces.com
    订购流程
  • 1. 在线订购
  • 请联系我们QQ客服

  • 2. 电话订购
  • 请拨打电话:
    027-84237683 或 027-84237783

  • 3. 邮件或传真订购
  • 发送电子邮件到: manager@chemfaces.com 或
    发送传真到:027-84254680

  • 提供订购信息
  • 为了方便客户的订购,请需要订购ChemFaces产品的客户,在下单的时候请提供下列信息,以供我们快速为您建立发货信息。
  •  
  • 1. 产品编号(CAS No.或产品名称)
  • 2. 发货地址
  • 3. 联系方法 (联系人,电话)
  • 4. 开票抬头 (如果需要发票的客户)
  • 5. 发票地址(发货地址与发票地址不同)
  • 发货时间
    1. 付款方式为100%预付款客户,我们将在确认收到货款后当天或1-3个工作日发货。

    2. 付款方式为月结的客户,我们承诺在收到订单后当天或1-3个工作日内发货。

    3. 如果客户所需要的产品,需要重新生产,我们有权告知客户,交货时间需要延期。
    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
    doi: 10.1016/j.cmet.2020.01.002.
    IF=22.415(2019)

    PMID: 32004475

    Mol Cell. 2017 Nov 16;68(4):673-685.e6.
    doi: 10.1016/j.molcel.2017.10.022.
    IF=14.548(2019)

    PMID: 29149595

    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
    doi: 10.1021/acsnano.7b08969.
    IF=13.903(2019)

    PMID: 29553709

    Nature Plants. 2016 Dec 22;3: 16206.
    doi: 10.1038/nplants.2016.205.
    IF=13.297(2019)

    PMID: 28005066

    Sci Adv. 2018 Oct 24;4(10): eaat6994.
    doi: 10.1126/sciadv.aat6994.
    IF=12.804(2019)

    PMID: 30417089
    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
  • Institute of Tropical Disease Universitas Airlangga (Indonesia)
  • Kyung Hee University (Korea)
  • Funda??o Universitária de Desenvolvimento (Brazil)
  • Periyar University (India)
  • Stanford University (USA)
  • Georgia Institute of Technology (USA)
  • University of Otago (New Zealand)
  • Max Rubner-Institut (MRI) (Germany)
  • Almansora University (Egypt)
  • University of Fribourg (Switzerland)
  • Gyeongsang National University (Korea)
  • Max-Planck-Insitut (Germany)
  • Macau University of Science and Technology (China)
  • Aveiro University (Portugal)
  • More...
  • 国外学术期刊发表的引用ChemFaces产品的部分文献
  • FEBS J.2022, 10.1111:febs.16676.
  • Nutrients2022, 14(3),695.
  • Pak J Pharm Sci.2019, 32(6)
  • Molecules.2019, 24(24):E4536
  • Sci Rep.2018, 8(1):12970
  • Int Immunopharmacol.2023, 123:110572.
  • Journal of Natural Remedies2024, 24(3):555–575.
  • Natural Product Communications2020, doi: 10.1177.
  • J Pharmacol Sci.2021, 147(2):184-191.
  • Life Sci.2019, 216:259-270
  • Allergol Immunopathol (Madr).2022, 1;50(4):23-30.
  • Industrial Crops and Products2022, 188:115596.
  • Food Science&Tech. Res.2022, 28(2):123-132.
  • FEBS Lett.2021, 595(20):2608-2615.
  • Journal of Applied Pharmaceutical Science2022, 0(00), pp:001-007
  • Biofactors.2018, 44(2):168-179
  • Int J Mol Sci.2023, 24(18):13713.
  • Int. Conference on Med. Sci. and Bio.2017, 17973
  • J Mol Med (Berl).2018, 96(7):661-672
  • Phytother Res.2023, 37(10):4587-4606.
  • Fermentation2023, 9(10), 889
  • Industrial Crops and Products2022, 188:115638
  • Molecules.2022, 27(21):7514.
  • ...
  • 生物活性
    Description: 6-Hydroxyflavone was previously reported to bind to type A γ-aminobutyric acid (GABAA) receptors benzodiazepine (BZ) site with moderate binding affinity, it as a promising drug candidate for the treatment of anxiety-like disorders. 6-Hydroxyflavone and 6-methoxyflavone with potent anti-inflammatory activity jin kidney mesangial cells provides a new flavone scaffold and direction to develop naturally derived products for potential nephritis prevention and treatment.
    Targets: GABAA receptor | NO
    In vitro:
    Plos one, 19 Mar 2015, 10(3):e0116409.
    6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells.[Reference: WebLink]
    Inflammatory responses by kidney mesangial cells play a critical role in the glomerulonephritis.
    METHODS AND RESULTS:
    The anti-inflammatory potential of nineteen mono-, di- and polyhydroxylated flavones including fisetin, quercetin, morin, tricetin, gossypetin, apigenin and myricetin were investigated on rat mesangial cells with lipopolysaccharide (LPS) as the inflammatory stimuli. 6-Hydroxyflavone and 4',6-dihydroxyflavone exhibited high activity with IC50 in the range of 2.0 μM, a much better inhibition potential in comparison to the well-studied polyhydroxylated flavones. Interestingly, the anti-inflammatory activity was not due to direct quenching of NO radicals. Investigation on derivatives with methylation, acetylation or sulfation of 6-hydroxyl group revealed that 6-methoxyflavone was the most potent with an IC50 of 192 nM. Mechanistic study indicated that the anti-inflammatory activity of 6-methoxyflavone arose via the inhibition of LPS-induced downstream inducible NO synthase in mesangial cells.
    CONCLUSIONS:
    The identification of 6-hydroxyflavone and 6-methoxyflavone with potent anti-inflammatory activity in kidney mesangial cells provides a new flavone scaffold and direction to develop naturally derived products for potential nephritis prevention and treatment.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 4.1982 mL 20.9908 mL 41.9815 mL 83.9631 mL 104.9538 mL
    5 mM 0.8396 mL 4.1982 mL 8.3963 mL 16.7926 mL 20.9908 mL
    10 mM 0.4198 mL 2.0991 mL 4.1982 mL 8.3963 mL 10.4954 mL
    50 mM 0.084 mL 0.4198 mL 0.8396 mL 1.6793 mL 2.0991 mL
    100 mM 0.042 mL 0.2099 mL 0.4198 mL 0.8396 mL 1.0495 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    红花黄色素 A; Safflor Yellow A CFN90262 85532-77-0 C27H30O15 = 594.52 5mg QQ客服:1413575084
    Trikamsteroside C; Trikamsteroside C CFN93330 952579-35-0 C47H70O24 = 1019.04 5mg QQ客服:2159513211
    Eucamalol; Eucamalol CFN99604 145544-91-8 C10H16O2 = 168.2 5mg QQ客服:1457312923
    胡椒碱; Piperine CFN99919 94-62-2 C17H19NO3 = 285.34 20mg QQ客服:1413575084

    信息支持


    公司简介
    订购流程
    付款方式
    退换货政策

    ChemFaces提供的产品仅用于科学研究使用,不用于诊断或治疗程序。

    联系方式


    电机:027-84237783
    传真:027-84254680
    在线QQ: 1413575084
    E-Mail:manager@chemfaces.com

    湖北省武汉沌口经济技术开区车城南路83号1号楼第三层厂房


    ChemFaces为科学家,科研人员与企业提供快速的产品递送。我们通过瑞士SGS ISO 9001:2008质量体系认证天然化合物与对照品的研发和生产