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  • 香芹酚

    5-Isopropyl-2-methylphenol

    香芹酚
    产品编号 CFN90491
    CAS编号 499-75-2
    分子式 = 分子量 C10H14O = 150.21
    产品纯度 >=98%
    物理属性 Oil
    化合物类型 Monoterpenoids
    植物来源 The herbs of Elsholtzia ciliata.
    ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用
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    香芹酚 CFN90491 499-75-2 10mg QQ客服:3257982914
    香芹酚 CFN90491 499-75-2 20mg QQ客服:3257982914
    香芹酚 CFN90491 499-75-2 50mg QQ客服:3257982914
    香芹酚 CFN90491 499-75-2 100mg QQ客服:3257982914
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    ChemFaces的产品在许多优秀和顶级科学期刊中被引用

    Cell. 2018 Jan 11;172(1-2):249-261.e12.
    doi: 10.1016/j.cell.2017.12.019.
    IF=36.216(2019)

    PMID: 29328914

    Cell Metab. 2020 Mar 3;31(3):534-548.e5.
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    ACS Nano. 2018 Apr 24;12(4): 3385-3396.
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    Nature Plants. 2016 Dec 22;3: 16206.
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    Sci Adv. 2018 Oct 24;4(10): eaat6994.
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    我们的产品现已经出口到下面的研究机构与大学,并且还在增涨
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  • UDC.2020, 19(4).
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  • BMB Rep.2020, 53(4):218-222.
  • Pharmaceuticals (Basel).2021, 14(6):588.
  • Molecules.2021, 26(2):E255.
  • Tokyo Pharmaceutical University2020, 500001431953.
  • BMC Plant Biol.2021, 21(1):60.
  • J Chromatogr B Analyt Technol Biomed Life Sci.2019, 1124:323-330
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  • ...
  • 生物活性
    Description: 5-Isopropyl-2-methylphenol presents anxiolytic, antinociceptive, and antidepressant effects, it seems to be dependent on its interaction with the dopaminergic system, but not with the serotonergic and noradrenergic systems.
    Targets: GABA Receptor
    In vivo:
    J Pharm Pharmacol. 2012 Dec;64(12):1722-9.
    Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice.[Pubmed: 23146035]
    Carvacrol (5-Isopropyl-2-methylphenol) is a monoterpenic phenol which is present in the essential oil of oregano and thyme. We have investigated the behavioural effects of 5-Isopropyl-2-methylphenol in animal models of pain, such as acetic acid-induced abdominal constriction, formalin and hot-plate tests in mice. The spontaneous motor activity of animals treated with 5-Isopropyl-2-methylphenol was investigated using open-field and rotarod tests.
    METHODS AND RESULTS:
    5-Isopropyl-2-methylphenol was administered orally, at single doses of 50 and 100 mg/kg while indometacin (5 mg/kg), morphine (7.5 mg/kg) and diazepam (2 mg/kg) were used as standard drugs. Naloxone (1 mg/kg) and l-arginine (150 mg/kg) were used to elucidate the possible antinociceptive mechanism of 5-Isopropyl-2-methylphenol on acetic acid-induced abdominal constriction and formalin tests. The results showed that 5-Isopropyl-2-methylphenol produced significant inhibitions on nociception in the acetic acid-induced abdominal constriction, formalin and hot-plate tests. In the open-field and rotarod tests 5-Isopropyl-2-methylphenol did not significantly impair the motor performance. The effect of the highest dose of 5-Isopropyl-2-methylphenol in mice in the acetic acid-induced abdominal constriction and formalin tests were not reversed by naloxone or l-arginine.
    CONCLUSIONS:
    Based on these results, it has been suggested that 5-Isopropyl-2-methylphenol presents antinociceptive activity that may not act through the opioid system nor through inhibition of the nitric oxide pathway.
    J Neurotrauma. 2012 Dec 10;29(18):2831-4.
    Carvacrol together with TRPC1 elimination improve functional recovery after traumatic brain injury in mice.[Pubmed: 22994850]
    We hypothesized that TRP channels of the TRPC subfamily may be involved in post-TBI pathophysiology and that the compound 5-Isopropyl-2-methylphenol (carvacrol), by inhibition of TRP channels, may exert neuroprotective effect after TBI.
    METHODS AND RESULTS:
    To test these suppositions, 5-Isopropyl-2-methylphenol was given to mice after TBI and its effect on their functional recovery was followed for several weeks. Our results show that neurological recovery after TBI was significantly enhanced by application of 5-Isopropyl-2-methylphenol. To better define the type of the specific channel involved, the effect of 5-Isopropyl-2-methylphenol on the extent and speed of recovery after TBI was compared among mice lacking TRPC1, TRPC3, or TRPC5, relative to wild type controls. We found that neurological recovery after TBI was significantly enhanced by combining 5-Isopropyl-2-methylphenol with TRPC1 elimination, but not by the absence of TRPC3 or TRPC5, showing a synergistic effect between 5-Isopropyl-2-methylphenol application and TRPC1 elimination.
    CONCLUSIONS:
    We conclude that TRPC1-sensitive mechanisms are involved in TBI pathology, and that inhibition of this channel by 5-Isopropyl-2-methylphenol enhances recovery and should be considered for further studies in animal models and humans.
    制备储备液(仅供参考)
    1 mg 5 mg 10 mg 20 mg 25 mg
    1 mM 6.6573 mL 33.2867 mL 66.5735 mL 133.1469 mL 166.4337 mL
    5 mM 1.3315 mL 6.6573 mL 13.3147 mL 26.6294 mL 33.2867 mL
    10 mM 0.6657 mL 3.3287 mL 6.6573 mL 13.3147 mL 16.6434 mL
    50 mM 0.1331 mL 0.6657 mL 1.3315 mL 2.6629 mL 3.3287 mL
    100 mM 0.0666 mL 0.3329 mL 0.6657 mL 1.3315 mL 1.6643 mL
    * Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
    部分图片展示
    产品名称 产品编号 CAS编号 分子式 = 分子量 位单 联系QQ
    百里酚; Thymol CFN93010 89-83-8 C10H14O = 150.2 20mg QQ客服:215959384
    2-(2'-羟基-4'-甲苯基)丙酸; 2-(2'-Hydroxy-4'-methylphenyl)propionic acid CFN91994 111044-84-9 C10H12O3 = 180.20 5mg QQ客服:2056216494
    9-羟基百里酚; 9-Hydroxythymol CFN91995 61955-76-8 C10H14O2 = 166.22 5mg QQ客服:2159513211
    8,9-Dihydroxy-10-isobutyryloxythymol; 8,9-Dihydroxy-10-isobutyryloxythymol CFN92999 107109-97-7 C14H20O5 = 268.31 5mg QQ客服:1413575084
    8-Hydroxy-9,10-diisobutyryloxythymol; 8-Hydroxy-9,10-diisobutyryloxythymol CFN89511 22518-08-7 C18H26O6 = 338.39 5mg QQ客服:2159513211
    香芹酚; 5-Isopropyl-2-methylphenol CFN90491 499-75-2 C10H14O = 150.21 20mg QQ客服:2056216494
    木里岚二醇; Mullilam diol CFN98490 36150-04-6 C10H20O3 = 188.3 5mg QQ客服:2159513211
    1-羟基异二氢葛缕醇; p-Menth-8-ene-1,2-diol CFN98967 57457-97-3 C10H18O2 = 170.3 5mg QQ客服:1457312923

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