4'-O-甲基补骨脂查尔酮
4'-O-Methylbroussochalcone B
|
|
产品编号 |
CFN98046 |
| CAS编号 |
20784-60-5 |
| 分子式 = 分子量 |
C21H22O4 = 338.4 |
| 产品纯度 |
>=98% |
| 物理属性 |
Yellow powder |
| 化合物类型 |
Chalcones |
| 植物来源 |
The seeds of Psoralea corylifolia Linn. |
| ChemFaces的产品在影响因子大于5的优秀和顶级科学期刊中被引用 |
|
| 产品名称 |
产品编号 |
CAS编号 |
包装 |
QQ客服 |
| 4'-O-甲基补骨脂查尔酮 |
CFN98046 |
20784-60-5 |
10mg |
QQ客服：215959384 |
| 4'-O-甲基补骨脂查尔酮 |
CFN98046 |
20784-60-5 |
20mg |
QQ客服：215959384 |
| 4'-O-甲基补骨脂查尔酮 |
CFN98046 |
20784-60-5 |
50mg |
QQ客服：215959384 |
| 4'-O-甲基补骨脂查尔酮 |
CFN98046 |
20784-60-5 |
100mg |
QQ客服：215959384 |
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ChemFaces的产品在许多优秀和顶级科学期刊中被引用
Cell. 2018 Jan 11;172(1-2):249-261.e12. doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)PMID: 29328914
Cell Metab. 2020 Mar 3;31(3):534-548.e5. doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)PMID: 32004475
Mol Cell. 2017 Nov 16;68(4):673-685.e6. doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)PMID: 29149595
ACS Nano. 2018 Apr 24;12(4): 3385-3396. doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)PMID: 29553709
Nature Plants. 2016 Dec 22;3: 16206. doi: 10.1038/nplants.2016.205.
IF=13.297(2019)PMID: 28005066
Sci Adv. 2018 Oct 24;4(10): eaat6994. doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)PMID: 30417089
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Helmholtz Zentrum München (Germany)
Nanjing University of Chinese Medicine (China)
University of Fribourg (Switzerland)
VIB Department of Plant Systems Biology, UGent (PSB) (Belgium)
Molecular Biology Institute of Barcelona (IBMB)-CSIC (Spain)
Sant Gadge Baba Amravati University (India)
University of Helsinki (Finland)
Medical University of Gdansk (Poland)
Universidade Federal de Santa Catarina (Brazil)
Universitas Airlangga (Indonesia)
MTT Agrifood Research Finland (Finland)
More...
国外学术期刊发表的引用ChemFaces产品的部分文献
| Description: |
Reference standards. |
| In vitro: |
| Journal of Natural Products,2018, 81(4):966-975. | | Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication.[Pubmed: 29641206] | Postmenopausal women are increasingly using botanicals for menopausal symptom relief due to the increased breast cancer risk associated with traditional estrogen therapy. The deleterious effects of estrogens are associated with estrogen receptor (ER)α-dependent proliferation, while ERβ activation could enhance safety by opposing ERα effects.
METHODS AND RESULTS:
Three medicinal licorice species, Glycyrrhiza glabra ( G. glabra), G. uralensis, and G. inflata, were studied for their differential estrogenic efficacy. The data showed higher estrogenic potency for G. inflata in an alkaline phosphatase induction assay in Ishikawa cells (ERα) and an estrogen responsive element (ERE)-luciferase assay in MDA-MB-231/β41 breast cancer cells (ERβ). Bioassay-guided fractionation of G. inflata led to the isolation of 8-prenylapigenin (3). Surprisingly, a commercial batch of 3 was devoid of estrogenic activity. Quality control by MS and qNMR revealed an incorrect compound, 4'- O-methylbroussochalcone B (10), illustrating the importance of both structural and purity verification prior to any biological investigations. Authentic and pure 3 displayed 14-fold preferential ERβ agonist activity. Quantitative analyses revealed that 3 was 33 times more concentrated in G. inflata compared to the other medicinal licorice extracts.
CONCLUSIONS:
These data suggest that standardization of G. inflata to 3 might enhance the safety and efficacy of G. inflata supplements used for postmenopausal women's health. |
|
|
1 mg |
5 mg |
10 mg |
20 mg |
25 mg |
| 1 mM |
2.9551 mL |
14.7754 mL |
29.5508 mL |
59.1017 mL |
73.8771 mL |
| 5 mM |
0.591 mL |
2.9551 mL |
5.9102 mL |
11.8203 mL |
14.7754 mL |
| 10 mM |
0.2955 mL |
1.4775 mL |
2.9551 mL |
5.9102 mL |
7.3877 mL |
| 50 mM |
0.0591 mL |
0.2955 mL |
0.591 mL |
1.182 mL |
1.4775 mL |
| 100 mM |
0.0296 mL |
0.1478 mL |
0.2955 mL |
0.591 mL |
0.7388 mL |
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
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